Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation

Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation

Many metabolic enzymes self-assemble into micron-scale filaments to organize and regulate metabolism. The appearance of these assemblies often coincides with large metabolic changes as in development, cancer, and stress. Yeast undergo cytoplasmic acidification upon starvation, triggering the assembl...

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Bibliographic Details
Main Authors: Jesse M Hansen, Avital Horowitz, Eric M Lynch, Daniel P Farrell, Joel Quispe, Frank DiMaio, Justin M Kollman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
stress response
metabolic filaments
enzyme allostery
cryo-EM
Online Access:https://elifesciences.org/articles/73368

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