Allopregnanolone: Regenerative therapeutic to restore neurological health
Chronic stress has been proposed as a driver of altered brain structure and function, including the pathogenesis of neurodegenerative diseases and a driver of disease progression. A key outcome of stress in the brain is structural remodeling of neural architecture, which may be a sign of successful...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-11-01
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| Series: | Neurobiology of Stress |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352289522000777 |
| _version_ | 1811178958633304064 |
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| author | Gerson D. Hernandez Roberta D. Brinton |
| author_facet | Gerson D. Hernandez Roberta D. Brinton |
| author_sort | Gerson D. Hernandez |
| collection | DOAJ |
| description | Chronic stress has been proposed as a driver of altered brain structure and function, including the pathogenesis of neurodegenerative diseases and a driver of disease progression. A key outcome of stress in the brain is structural remodeling of neural architecture, which may be a sign of successful adaptation, whereas persistence of these changes when stress ends indicate failed resilience. Neuroendocrine homeostasis and stress response are mainly dependent upon the functioning of the hypothalamic–pituitary–adrenal axis. Neurosteroids will fluctuate depending on whether the stress is acute or chronic. Advancements in neurosteroid research have led to the identification of multiple targets for drug development, but the most promising innovative target may be neurogenesis, given its potential impact in neurodegenerative disorders like Alzheimer's disease. Allopregnanolone is an endogenous pregnane neurosteroid and a reduced metabolite of progesterone, which acts as a potent allosteric modulator and direct activator of the GABA-chloride channel complex. Perhaps the most intriguing finding related to the potential therapeutic effects of allopregnanolone is its potential to promote neuroregeneration. |
| first_indexed | 2024-04-11T06:27:52Z |
| format | Article |
| id | doaj.art-e9599b8a21e54e218fe53b446ee5e4e9 |
| institution | Directory Open Access Journal |
| issn | 2352-2895 |
| language | English |
| last_indexed | 2024-04-11T06:27:52Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj.art-e9599b8a21e54e218fe53b446ee5e4e92022-12-22T04:40:19ZengElsevierNeurobiology of Stress2352-28952022-11-0121100502Allopregnanolone: Regenerative therapeutic to restore neurological healthGerson D. Hernandez0Roberta D. Brinton1Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, USACorresponding author. 1230 N. Cherry Avenue PO Box 210242, Tucson, AZ, 85721-0242, USA.; Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, USAChronic stress has been proposed as a driver of altered brain structure and function, including the pathogenesis of neurodegenerative diseases and a driver of disease progression. A key outcome of stress in the brain is structural remodeling of neural architecture, which may be a sign of successful adaptation, whereas persistence of these changes when stress ends indicate failed resilience. Neuroendocrine homeostasis and stress response are mainly dependent upon the functioning of the hypothalamic–pituitary–adrenal axis. Neurosteroids will fluctuate depending on whether the stress is acute or chronic. Advancements in neurosteroid research have led to the identification of multiple targets for drug development, but the most promising innovative target may be neurogenesis, given its potential impact in neurodegenerative disorders like Alzheimer's disease. Allopregnanolone is an endogenous pregnane neurosteroid and a reduced metabolite of progesterone, which acts as a potent allosteric modulator and direct activator of the GABA-chloride channel complex. Perhaps the most intriguing finding related to the potential therapeutic effects of allopregnanolone is its potential to promote neuroregeneration.http://www.sciencedirect.com/science/article/pii/S2352289522000777NeurosteroidsAllopregnanoloneRegenerative therapeuticNeurogenesis |
| spellingShingle | Gerson D. Hernandez Roberta D. Brinton Allopregnanolone: Regenerative therapeutic to restore neurological health Neurobiology of Stress Neurosteroids Allopregnanolone Regenerative therapeutic Neurogenesis |
| title | Allopregnanolone: Regenerative therapeutic to restore neurological health |
| title_full | Allopregnanolone: Regenerative therapeutic to restore neurological health |
| title_fullStr | Allopregnanolone: Regenerative therapeutic to restore neurological health |
| title_full_unstemmed | Allopregnanolone: Regenerative therapeutic to restore neurological health |
| title_short | Allopregnanolone: Regenerative therapeutic to restore neurological health |
| title_sort | allopregnanolone regenerative therapeutic to restore neurological health |
| topic | Neurosteroids Allopregnanolone Regenerative therapeutic Neurogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S2352289522000777 |
| work_keys_str_mv | AT gersondhernandez allopregnanoloneregenerativetherapeutictorestoreneurologicalhealth AT robertadbrinton allopregnanoloneregenerativetherapeutictorestoreneurologicalhealth |