Continuous renal replacement therapy in neonates weighing less than 3 kg
PurposeContinuous renal replacement therapy (CRRT) is becoming the treatment of choice for supporting critically ill pediatric patients. However, a few studies present have reported CRRT use and outcome in neonates weighing less than 3 kg. The aim of this study is to describe the clinical applicatio...
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| Format: | Article |
| Language: | English |
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Korean Pediatric Society
2012-08-01
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| Series: | Korean Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://kjp.or.kr/upload/pdf/kjped-55-286.pdf |
| _version_ | 1823960441088376832 |
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| author | Young Bae Sohn Kyung Hoon Paik Hee Yeon Cho Su Jin Kim Sung Won Park Eun Sun Kim Yun Sil Chang Won-Soon Park Yoon-Ho Choi Dong-Kyu Jin |
| author_facet | Young Bae Sohn Kyung Hoon Paik Hee Yeon Cho Su Jin Kim Sung Won Park Eun Sun Kim Yun Sil Chang Won-Soon Park Yoon-Ho Choi Dong-Kyu Jin |
| author_sort | Young Bae Sohn |
| collection | DOAJ |
| description | PurposeContinuous renal replacement therapy (CRRT) is becoming the treatment of choice for supporting critically ill pediatric patients. However, a few studies present have reported CRRT use and outcome in neonates weighing less than 3 kg. The aim of this study is to describe the clinical application, outcome, and complications of CRRT in small neonates.MethodsA retrospective review was performed in 8 neonatal patients who underwent at least 24 hours of pumped venovenous CRRT at the Samsung Medical Center in Seoul, Korea, between March 2007 and July 2010. Data, including demographic characteristics, diagnosis, vital signs, medications, laboratory, and CRRT parameters were recorded.ResultsThe data of 8 patients were analyzed. At the initiation of CRRT, the median age was 5 days (corrected age, 38+2 weeks to 23 days), and the median body weight was 2.73 kg (range, 2.60 to 2.98 kg). Sixty-two patient-days of therapy were reviewed; the median time for CRRT in each patient was 7.8 days (range, 1 to 37 days). Adverse events included electrolyte disturbances, catheter-related complications, and CRRT-related hypotension. The mean circuit functional survival was 13.9±8.6 hours. Overall, 4 patients (50%) survived; the other 4 patients, who developed multiorgan dysfunction syndrome, died.ConclusionThe complications of CRRT in newborns are relatively high. However, the results of this study suggest that venovenous CRRT is feasible and effective in neonates weighing less than 3 kg under elaborate supportive care. Furthermore, for using potential benefit of CRRT in neonates, efforts are required for prolonging filter survival. |
| first_indexed | 2024-12-17T16:48:59Z |
| format | Article |
| id | doaj.art-e95bb57addcd4a0f82c8f99407d3bc59 |
| institution | Directory Open Access Journal |
| issn | 1738-1061 2092-7258 |
| language | English |
| last_indexed | 2024-12-17T16:48:59Z |
| publishDate | 2012-08-01 |
| publisher | Korean Pediatric Society |
| record_format | Article |
| series | Korean Journal of Pediatrics |
| spelling | doaj.art-e95bb57addcd4a0f82c8f99407d3bc592022-12-21T21:40:39ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582012-08-0155828629210.3345/kjp.2012.55.8.2862012600027Continuous renal replacement therapy in neonates weighing less than 3 kgYoung Bae Sohn0Kyung Hoon Paik1Hee Yeon Cho2Su Jin Kim3Sung Won Park4Eun Sun Kim5Yun Sil Chang6Won-Soon Park7Yoon-Ho Choi8Dong-Kyu Jin9Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Pediatrics, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea.Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.PurposeContinuous renal replacement therapy (CRRT) is becoming the treatment of choice for supporting critically ill pediatric patients. However, a few studies present have reported CRRT use and outcome in neonates weighing less than 3 kg. The aim of this study is to describe the clinical application, outcome, and complications of CRRT in small neonates.MethodsA retrospective review was performed in 8 neonatal patients who underwent at least 24 hours of pumped venovenous CRRT at the Samsung Medical Center in Seoul, Korea, between March 2007 and July 2010. Data, including demographic characteristics, diagnosis, vital signs, medications, laboratory, and CRRT parameters were recorded.ResultsThe data of 8 patients were analyzed. At the initiation of CRRT, the median age was 5 days (corrected age, 38+2 weeks to 23 days), and the median body weight was 2.73 kg (range, 2.60 to 2.98 kg). Sixty-two patient-days of therapy were reviewed; the median time for CRRT in each patient was 7.8 days (range, 1 to 37 days). Adverse events included electrolyte disturbances, catheter-related complications, and CRRT-related hypotension. The mean circuit functional survival was 13.9±8.6 hours. Overall, 4 patients (50%) survived; the other 4 patients, who developed multiorgan dysfunction syndrome, died.ConclusionThe complications of CRRT in newborns are relatively high. However, the results of this study suggest that venovenous CRRT is feasible and effective in neonates weighing less than 3 kg under elaborate supportive care. Furthermore, for using potential benefit of CRRT in neonates, efforts are required for prolonging filter survival.http://kjp.or.kr/upload/pdf/kjped-55-286.pdfCritical illnessInfantRenal replacement therapyTreatment outcome |
| spellingShingle | Young Bae Sohn Kyung Hoon Paik Hee Yeon Cho Su Jin Kim Sung Won Park Eun Sun Kim Yun Sil Chang Won-Soon Park Yoon-Ho Choi Dong-Kyu Jin Continuous renal replacement therapy in neonates weighing less than 3 kg Korean Journal of Pediatrics Critical illness Infant Renal replacement therapy Treatment outcome |
| title | Continuous renal replacement therapy in neonates weighing less than 3 kg |
| title_full | Continuous renal replacement therapy in neonates weighing less than 3 kg |
| title_fullStr | Continuous renal replacement therapy in neonates weighing less than 3 kg |
| title_full_unstemmed | Continuous renal replacement therapy in neonates weighing less than 3 kg |
| title_short | Continuous renal replacement therapy in neonates weighing less than 3 kg |
| title_sort | continuous renal replacement therapy in neonates weighing less than 3 kg |
| topic | Critical illness Infant Renal replacement therapy Treatment outcome |
| url | http://kjp.or.kr/upload/pdf/kjped-55-286.pdf |
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