Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats

Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats

Afatinib, as the first-line treatment for non-small cell lung cancer (NSCLC), causes severe gastrointestinal adverse reactions that greatly affect patients' quality of life and even potentially result in treatment discontinuation. Multiple dose adjustments and concomitant use of anti-diarrheal...

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Bibliographic Details
Main Authors: Li Zhang, Anna Hu, Yan Wang, Yuxin Yang, Yalan Liu, Lian Xu, Lei Wang, Zeneng Cheng
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Afatinib
Diarrhea management
DPP4
Sitagliptin
GLP-23-33
Gut microbiota
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558623000477

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