The Mitochondrial Prohibitin (PHB) Complex in <i>C. elegans</i> Metabolism and Ageing Regulation
The mitochondrial prohibitin (PHB) complex, composed of PHB-1 and PHB-2, is an evolutionarily conserved context-dependent modulator of longevity. This extremely intriguing phenotype has been linked to alterations in mitochondrial function and lipid metabolism. The true biochemical function of the mi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/11/9/636 |
| _version_ | 1797518271011880960 |
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| author | Artur B. Lourenço Marta Artal-Sanz |
| author_facet | Artur B. Lourenço Marta Artal-Sanz |
| author_sort | Artur B. Lourenço |
| collection | DOAJ |
| description | The mitochondrial prohibitin (PHB) complex, composed of PHB-1 and PHB-2, is an evolutionarily conserved context-dependent modulator of longevity. This extremely intriguing phenotype has been linked to alterations in mitochondrial function and lipid metabolism. The true biochemical function of the mitochondrial PHB complex remains elusive, but it has been shown to affect membrane lipid composition. Recent work, using large-scale biochemical approaches, has highlighted a broad effect of PHB on the <i>C. elegans</i> metabolic network. Collectively, the biochemical data support the notion that PHB modulates, at least partially, worm longevity through the moderation of fat utilisation and energy production via the mitochondrial respiratory chain. Herein, we review, in a systematic manner, recent biochemical insights into the impact of PHB on the <i>C. elegans</i> metabolome. |
| first_indexed | 2024-03-10T07:27:32Z |
| format | Article |
| id | doaj.art-e95c4d25a21e4c8f9320bca3d63ba50b |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T07:27:32Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-e95c4d25a21e4c8f9320bca3d63ba50b2023-11-22T14:12:08ZengMDPI AGMetabolites2218-19892021-09-0111963610.3390/metabo11090636The Mitochondrial Prohibitin (PHB) Complex in <i>C. elegans</i> Metabolism and Ageing RegulationArtur B. Lourenço0Marta Artal-Sanz1Andalusian Centre for Developmental Biology (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Carretera de Utrera Km 1, 41013 Seville, SpainAndalusian Centre for Developmental Biology (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Carretera de Utrera Km 1, 41013 Seville, SpainThe mitochondrial prohibitin (PHB) complex, composed of PHB-1 and PHB-2, is an evolutionarily conserved context-dependent modulator of longevity. This extremely intriguing phenotype has been linked to alterations in mitochondrial function and lipid metabolism. The true biochemical function of the mitochondrial PHB complex remains elusive, but it has been shown to affect membrane lipid composition. Recent work, using large-scale biochemical approaches, has highlighted a broad effect of PHB on the <i>C. elegans</i> metabolic network. Collectively, the biochemical data support the notion that PHB modulates, at least partially, worm longevity through the moderation of fat utilisation and energy production via the mitochondrial respiratory chain. Herein, we review, in a systematic manner, recent biochemical insights into the impact of PHB on the <i>C. elegans</i> metabolome.https://www.mdpi.com/2218-1989/11/9/636mitochondrial prohibitin complexmetabolismageing |
| spellingShingle | Artur B. Lourenço Marta Artal-Sanz The Mitochondrial Prohibitin (PHB) Complex in <i>C. elegans</i> Metabolism and Ageing Regulation Metabolites mitochondrial prohibitin complex metabolism ageing |
| title | The Mitochondrial Prohibitin (PHB) Complex in <i>C. elegans</i> Metabolism and Ageing Regulation |
| title_full | The Mitochondrial Prohibitin (PHB) Complex in <i>C. elegans</i> Metabolism and Ageing Regulation |
| title_fullStr | The Mitochondrial Prohibitin (PHB) Complex in <i>C. elegans</i> Metabolism and Ageing Regulation |
| title_full_unstemmed | The Mitochondrial Prohibitin (PHB) Complex in <i>C. elegans</i> Metabolism and Ageing Regulation |
| title_short | The Mitochondrial Prohibitin (PHB) Complex in <i>C. elegans</i> Metabolism and Ageing Regulation |
| title_sort | mitochondrial prohibitin phb complex in i c elegans i metabolism and ageing regulation |
| topic | mitochondrial prohibitin complex metabolism ageing |
| url | https://www.mdpi.com/2218-1989/11/9/636 |
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