Effect of one-lung ventilation on the correlation between left and right cerebral saturation
Abstract Background To investigate if the correlation between left and right cerebral tissue oxygen saturation (SctO2) was affected by one-lung ventilation (OLV) in patients undergoing lung cancer surgery. Methods Patients who underwent surgery for lung cancer were enrolled. Left and right SctO2 wer...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-023-02001-7 |
| _version_ | 1811165804694077440 |
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| author | Cai-Juan Zhang Jia-Hui Ma Fan Jin Xiu-Hua Li Hui-Qun Jia Dong-Liang Mu |
| author_facet | Cai-Juan Zhang Jia-Hui Ma Fan Jin Xiu-Hua Li Hui-Qun Jia Dong-Liang Mu |
| author_sort | Cai-Juan Zhang |
| collection | DOAJ |
| description | Abstract Background To investigate if the correlation between left and right cerebral tissue oxygen saturation (SctO2) was affected by one-lung ventilation (OLV) in patients undergoing lung cancer surgery. Methods Patients who underwent surgery for lung cancer were enrolled. Left and right SctO2 were collected during anesthesia. The primary outcome was the correlation between left and right SctO2 at 30 min after OLV which was analysed by Pearson correlation and linear regression model. Secondary outcomes included the trend of left–right SctO2 change over the first 30 min after OLV, correlation of left–right SctO2 during OLV for each patient; maximal difference between left–right SctO2 and its relationship with postoperative delirium. Results Left–right SctO2 was moderately correlated at baseline (r = 0.690, P < 0.001) and poorly correlated at 30 min after OLV (r = 0.383, P < 0.001) in the Pearson correlation analysis. Linear regression analysis showed a poor correlation between left and right SctO2 at 30 min after OLV (r = 0.323, P < 0.001) after adjusting for confounders. The linear mixed model showed a change in left–right SctO2 over the first 30 min after OLV that was statistically significant (coefficient, -0.042; 95% CI, -0.070–-0.014; P = 0.004). For the left–right SctO2 correlation during OLV in each patient, 62.9% (78/124) patients showed a strong correlation, 19.4% (24/124) a medium correlation, and the rest a poor correlation. The maximal difference between the left and right SctO2 was 13.5 (9.0, 20.0). Multivariate analysis showed that it was not associated with delirium (odds ratio [OR], 1.023; 95% CI, 0.963–1.087; P = 0.463). Conclusions The correlation between left and right SctO2 was affected by one-lung ventilation in patients undergoing lung cancer surgery. This result indicates the requirement of bilateral SctO2 monitoring to reflect brain oxygenation. Trial registration This study was a secondary analysis of a cohort study approved by the Clinical Research Review Board of Peking University First Hospital (#2017–1378) and was registered in the Chinese Clinical Trial Registry on 10/09/2017 ( http://www.chictr.org.cn , ChiCTR-ROC-17012627). |
| first_indexed | 2024-04-10T15:42:34Z |
| format | Article |
| id | doaj.art-e95c85c53efb460997a0e834fafe912e |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-04-10T15:42:34Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-e95c85c53efb460997a0e834fafe912e2023-02-12T12:20:32ZengBMCBMC Anesthesiology1471-22532023-02-012311910.1186/s12871-023-02001-7Effect of one-lung ventilation on the correlation between left and right cerebral saturationCai-Juan Zhang0Jia-Hui Ma1Fan Jin2Xiu-Hua Li3Hui-Qun Jia4Dong-Liang Mu5Department of Anesthesiology, Fourth Hospital of Hebei Medical UniversityDepartment of Anesthesiology, Peking University First HospitalDepartment of Anesthesiology, Fourth Hospital of Hebei Medical UniversityDepartment of Anesthesiology, Tangshan Gongren HospitalDepartment of Anesthesiology, Fourth Hospital of Hebei Medical UniversityDepartment of Anesthesiology, Peking University First HospitalAbstract Background To investigate if the correlation between left and right cerebral tissue oxygen saturation (SctO2) was affected by one-lung ventilation (OLV) in patients undergoing lung cancer surgery. Methods Patients who underwent surgery for lung cancer were enrolled. Left and right SctO2 were collected during anesthesia. The primary outcome was the correlation between left and right SctO2 at 30 min after OLV which was analysed by Pearson correlation and linear regression model. Secondary outcomes included the trend of left–right SctO2 change over the first 30 min after OLV, correlation of left–right SctO2 during OLV for each patient; maximal difference between left–right SctO2 and its relationship with postoperative delirium. Results Left–right SctO2 was moderately correlated at baseline (r = 0.690, P < 0.001) and poorly correlated at 30 min after OLV (r = 0.383, P < 0.001) in the Pearson correlation analysis. Linear regression analysis showed a poor correlation between left and right SctO2 at 30 min after OLV (r = 0.323, P < 0.001) after adjusting for confounders. The linear mixed model showed a change in left–right SctO2 over the first 30 min after OLV that was statistically significant (coefficient, -0.042; 95% CI, -0.070–-0.014; P = 0.004). For the left–right SctO2 correlation during OLV in each patient, 62.9% (78/124) patients showed a strong correlation, 19.4% (24/124) a medium correlation, and the rest a poor correlation. The maximal difference between the left and right SctO2 was 13.5 (9.0, 20.0). Multivariate analysis showed that it was not associated with delirium (odds ratio [OR], 1.023; 95% CI, 0.963–1.087; P = 0.463). Conclusions The correlation between left and right SctO2 was affected by one-lung ventilation in patients undergoing lung cancer surgery. This result indicates the requirement of bilateral SctO2 monitoring to reflect brain oxygenation. Trial registration This study was a secondary analysis of a cohort study approved by the Clinical Research Review Board of Peking University First Hospital (#2017–1378) and was registered in the Chinese Clinical Trial Registry on 10/09/2017 ( http://www.chictr.org.cn , ChiCTR-ROC-17012627).https://doi.org/10.1186/s12871-023-02001-7Cerebral tissue saturationCorrelationOne-lung ventilationLung cancer |
| spellingShingle | Cai-Juan Zhang Jia-Hui Ma Fan Jin Xiu-Hua Li Hui-Qun Jia Dong-Liang Mu Effect of one-lung ventilation on the correlation between left and right cerebral saturation BMC Anesthesiology Cerebral tissue saturation Correlation One-lung ventilation Lung cancer |
| title | Effect of one-lung ventilation on the correlation between left and right cerebral saturation |
| title_full | Effect of one-lung ventilation on the correlation between left and right cerebral saturation |
| title_fullStr | Effect of one-lung ventilation on the correlation between left and right cerebral saturation |
| title_full_unstemmed | Effect of one-lung ventilation on the correlation between left and right cerebral saturation |
| title_short | Effect of one-lung ventilation on the correlation between left and right cerebral saturation |
| title_sort | effect of one lung ventilation on the correlation between left and right cerebral saturation |
| topic | Cerebral tissue saturation Correlation One-lung ventilation Lung cancer |
| url | https://doi.org/10.1186/s12871-023-02001-7 |
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