Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C
The antibody response to the SARS-CoV-2 Omicron variant is not well studied in children. Here, the authors provide an age-stratified analysis of SARS-CoV-2 neutralizing capacity of sera from children with acute or convalescent COVID-19 as well as children with multisystem inflammatory syndrome.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30649-1 |
| _version_ | 1828348096667451392 |
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| author | Juanjie Tang Tanya Novak Julian Hecker Gabrielle Grubbs Fatema Tuz Zahra Lorenza Bellusci Sara Pourhashemi Janet Chou Kristin Moffitt Natasha B. Halasa Stephanie P. Schwartz Tracie C. Walker Keiko M. Tarquinio Matt S. Zinter Mary A. Staat Shira J. Gertz Natalie Z. Cvijanovich Jennifer E. Schuster Laura L. Loftis Bria M. Coates Elizabeth H. Mack Katherine Irby Julie C. Fitzgerald Courtney M. Rowan Michele Kong Heidi R. Flori Aline B. Maddux Steven L. Shein Hillary Crandall Janet R. Hume Charlotte V. Hobbs Adriana H. Tremoulet Chisato Shimizu Jane C. Burns Sabrina R. Chen Hye Kyung Moon Christoph Lange Adrienne G. Randolph Surender Khurana |
| author_facet | Juanjie Tang Tanya Novak Julian Hecker Gabrielle Grubbs Fatema Tuz Zahra Lorenza Bellusci Sara Pourhashemi Janet Chou Kristin Moffitt Natasha B. Halasa Stephanie P. Schwartz Tracie C. Walker Keiko M. Tarquinio Matt S. Zinter Mary A. Staat Shira J. Gertz Natalie Z. Cvijanovich Jennifer E. Schuster Laura L. Loftis Bria M. Coates Elizabeth H. Mack Katherine Irby Julie C. Fitzgerald Courtney M. Rowan Michele Kong Heidi R. Flori Aline B. Maddux Steven L. Shein Hillary Crandall Janet R. Hume Charlotte V. Hobbs Adriana H. Tremoulet Chisato Shimizu Jane C. Burns Sabrina R. Chen Hye Kyung Moon Christoph Lange Adrienne G. Randolph Surender Khurana |
| author_sort | Juanjie Tang |
| collection | DOAJ |
| description | The antibody response to the SARS-CoV-2 Omicron variant is not well studied in children. Here, the authors provide an age-stratified analysis of SARS-CoV-2 neutralizing capacity of sera from children with acute or convalescent COVID-19 as well as children with multisystem inflammatory syndrome. |
| first_indexed | 2024-04-14T00:49:21Z |
| format | Article |
| id | doaj.art-e95d32cb646c4ee9abe90f1a0721b0aa |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-14T00:49:21Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e95d32cb646c4ee9abe90f1a0721b0aa2022-12-22T02:21:51ZengNature PortfolioNature Communications2041-17232022-05-0113111010.1038/s41467-022-30649-1Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-CJuanjie Tang0Tanya Novak1Julian Hecker2Gabrielle Grubbs3Fatema Tuz Zahra4Lorenza Bellusci5Sara Pourhashemi6Janet Chou7Kristin Moffitt8Natasha B. Halasa9Stephanie P. Schwartz10Tracie C. Walker11Keiko M. Tarquinio12Matt S. Zinter13Mary A. Staat14Shira J. Gertz15Natalie Z. Cvijanovich16Jennifer E. Schuster17Laura L. Loftis18Bria M. Coates19Elizabeth H. Mack20Katherine Irby21Julie C. Fitzgerald22Courtney M. Rowan23Michele Kong24Heidi R. Flori25Aline B. Maddux26Steven L. Shein27Hillary Crandall28Janet R. Hume29Charlotte V. Hobbs30Adriana H. Tremoulet31Chisato Shimizu32Jane C. Burns33Sabrina R. Chen34Hye Kyung Moon35Christoph Lange36Adrienne G. Randolph37Surender Khurana38Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDADepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s HospitalChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDADivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDADivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDADivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDADepartment of Pediatrics, Boston Children’s Hospital and Harvard Medical SchoolDepartment of Pediatrics, Boston Children’s Hospital and Harvard Medical SchoolDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical CenterDepartment of Pediatrics, University of North Carolina at Chapel Hill Children’s HospitalDepartment of Pediatrics, University of North Carolina at Chapel Hill Children’s HospitalDivision of Critical Care Medicine, Department of Pediatrics, Emory University School of Medicine, Children’s Healthcare of AtlantaDepartment of Pediatrics, Divisions of Critical Care and Bone Marrow Transplantation, University of California, San FranciscoDepartment of Pediatrics, University of Cincinnati, Division of Infectious Diseases, Cincinnati Children’s Hospital Medical CenterDivision of Pediatric Critical Care, Department of Pediatrics, Cooperman Barnabas Medical CenterDivision of Critical Care Medicine, UCSF Benioff Children’s Hospital OaklandDivision of Pediatric Infectious Diseases, Department of Pediatrics, Children’s Mercy Kansas CityDivision of Critical Care Medicine, Department of Pediatrics, Baylor College of MedicineDivision of Critical Care Medicine, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of ChicagoDivision of Pediatric Critical Care Medicine, Medical University of South CarolinaSection of Pediatric Critical Care, Department of Pediatrics, Arkansas Children’s HospitalDivision of Critical Care, Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of MedicineDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for ChildrenDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Alabama at BirminghamDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Mott Children’s Hospital and University of MichiganDepartment of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children’s Hospital ColoradoDivision of Pediatric Critical Care Medicine, Rainbow Babies and Children’s HospitalDivision of Pediatric Critical Care, Department of Pediatrics, University of UtahDivision of Pediatric Critical Care, University of Minnesota Masonic Children’s HospitalDepartment of Pediatrics, Department of Microbiology, Division of Infectious Diseases, University of Mississippi Medical CenterKawasaki Disease Research Center, Rady Children’s Hospital and Department of Pediatrics, UCSD School of MedicineKawasaki Disease Research Center, Rady Children’s Hospital and Department of Pediatrics, UCSD School of MedicineKawasaki Disease Research Center, Rady Children’s Hospital and Department of Pediatrics, UCSD School of MedicineDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s HospitalDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s HospitalDepartment of Biostatistics, Harvard T.H. Chan School of Public HealthDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s HospitalDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDAThe antibody response to the SARS-CoV-2 Omicron variant is not well studied in children. Here, the authors provide an age-stratified analysis of SARS-CoV-2 neutralizing capacity of sera from children with acute or convalescent COVID-19 as well as children with multisystem inflammatory syndrome.https://doi.org/10.1038/s41467-022-30649-1 |
| spellingShingle | Juanjie Tang Tanya Novak Julian Hecker Gabrielle Grubbs Fatema Tuz Zahra Lorenza Bellusci Sara Pourhashemi Janet Chou Kristin Moffitt Natasha B. Halasa Stephanie P. Schwartz Tracie C. Walker Keiko M. Tarquinio Matt S. Zinter Mary A. Staat Shira J. Gertz Natalie Z. Cvijanovich Jennifer E. Schuster Laura L. Loftis Bria M. Coates Elizabeth H. Mack Katherine Irby Julie C. Fitzgerald Courtney M. Rowan Michele Kong Heidi R. Flori Aline B. Maddux Steven L. Shein Hillary Crandall Janet R. Hume Charlotte V. Hobbs Adriana H. Tremoulet Chisato Shimizu Jane C. Burns Sabrina R. Chen Hye Kyung Moon Christoph Lange Adrienne G. Randolph Surender Khurana Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C Nature Communications |
| title | Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C |
| title_full | Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C |
| title_fullStr | Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C |
| title_full_unstemmed | Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C |
| title_short | Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C |
| title_sort | cross reactive immunity against the sars cov 2 omicron variant is low in pediatric patients with prior covid 19 or mis c |
| url | https://doi.org/10.1038/s41467-022-30649-1 |
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