Correlation between demyelinating lesions and executive function decline in a sample of Mexican patients with multiple sclerosis
Background: Multiple sclerosis (MS) is characterised by several neurological symptoms including cognitive impairment, which has recently been the subject of considerable study. At present, evidence pointing to a correlation between lesion characteristics and specific cognitive impairment is not conc...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier España
2013-09-01
|
| Series: | Neurología (English Edition) |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S217358081300120X |
| _version_ | 1819178879753912320 |
|---|---|
| author | V.R. Aldrete Cortez E. Duriez-Sotelo P. Carrillo-Mora J.A. Pérez-Zuno |
| author_facet | V.R. Aldrete Cortez E. Duriez-Sotelo P. Carrillo-Mora J.A. Pérez-Zuno |
| author_sort | V.R. Aldrete Cortez |
| collection | DOAJ |
| description | Background: Multiple sclerosis (MS) is characterised by several neurological symptoms including cognitive impairment, which has recently been the subject of considerable study. At present, evidence pointing to a correlation between lesion characteristics and specific cognitive impairment is not conclusive. Objective: To investigate the presence of a correlation between the characteristics of demyelinating lesions and performance of basic executive functions in a sample of MS patients. Material and methods: We included 21 adult patients with scores of 0 to 5 on the Kurtzke scale and no exacerbations of the disease in at least 3 months prior to the evaluation date. They completed the Stroop test and the Wisconsin Card Sorting Test (WCST). The location of the lesions was determined using magnetic resonance imaging (MRI) performed by a blinded expert in neuroimaging. Results: Demyelinating lesions were more frequently located in the frontal and occipital lobes. The Stroop test showed that as cognitive demand increased on each of the sections in the test, reaction time and number of errors increased. On the WCST, 33.33% of patients registered as having moderate cognitive impairment. No correlation could be found between demyelinating lesion characteristics (location, size, and number) and patients’ scores on the tests. Conclusion: Explanations of the causes of cognitive impairment in MS should examine a variety of biological, psychological, and social factors instead of focusing solely on demyelinating lesions. Resumen: Antecedentes: La Esclerosis Múltiple (EM) se caracteriza por una gran diversidad de síntomas neurológicos de entre los cuales el deterioro cognitivo recientemente ha cobrado una especial relevancia. Hasta el momento la evidencia acerca de una correlación entre las características de las lesiones y el deterioro cognitivo específico aún no es concluyente. Objetivo: Analizar si existe una correlación entre las características de las lesiones desmielinizantes y el desempeño de las funciones ejecutivas básicas en estos pacientes. Pacientes y Métodos: Se incluyeron 21 pacientes adultos con puntaje de 0-5 en la escala de Kurtzke, sin exacerbaciones de la enfermedad en los 3 meses previos a la evaluación. Se les aplicaron las pruebas de Stroop, y el Wisconsin Card Sorting Test (WCST). La localización de las lesiones fue determinada por Resonancia Magnética por un observador experto y cegado Resultados: Las lesiones desmielinizantes se distribuyeron con mayor frecuencia en los lóbulos occipitales y frontales. En el Stroop se observó que, a medida que se incrementa la demanda cognitiva en cada sección de la prueba, aumentan el tiempo de reacción y el número de errores. En el WCST, un 33.33% presentó un deterioro medio a moderado. No se encontró una relación entre la lesiones desmielinizantes – localización, tamaño y suma total – y los puntajes de las pruebas aplicadas. Conclusión: En la explicación del deterioro cognitivo en la EM, se deben considerar no sólo a las lesiones desmielinizantes sino también otros factores biológicos, psicológicos y sociales. Keywords: Multiple sclerosis, Cognitive impairment, Executive functions, Demyelinating lesions, Neuropsychology, Mexico, Palabras clave: Esclerosis múltiple, Deterioro cognitivo, Funciones ejecutivas, Lesiones desmielinizantes, Neuropsicología, México |
| first_indexed | 2024-12-22T21:49:34Z |
| format | Article |
| id | doaj.art-e95e481e5ff4415ab0ae27ba2f0c9588 |
| institution | Directory Open Access Journal |
| issn | 2173-5808 |
| language | English |
| last_indexed | 2024-12-22T21:49:34Z |
| publishDate | 2013-09-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Neurología (English Edition) |
| spelling | doaj.art-e95e481e5ff4415ab0ae27ba2f0c95882022-12-21T18:11:24ZengElsevier EspañaNeurología (English Edition)2173-58082013-09-01287394399Correlation between demyelinating lesions and executive function decline in a sample of Mexican patients with multiple sclerosisV.R. Aldrete Cortez0E. Duriez-Sotelo1P. Carrillo-Mora2J.A. Pérez-Zuno3Departamento de Neurología del desarrollo, Instituto Nacional de Perinatología Montes Urales 800, Col Virreyes, Delegación Miguel Hidalgo, México, DF, Mexico; Corresponding author.Departamento de Neurología, Hospital CIMA, San Pedro Garza García, Nuevo León, México, MexicoServicio de Rehabilitación Neurológica, Instituto Nacional de Rehabilitación, Calz. México-Xochimilco, México, DF, MexicoDepartamento de Neurología, Hospital CIMA, San Pedro Garza García, Nuevo León, México, MexicoBackground: Multiple sclerosis (MS) is characterised by several neurological symptoms including cognitive impairment, which has recently been the subject of considerable study. At present, evidence pointing to a correlation between lesion characteristics and specific cognitive impairment is not conclusive. Objective: To investigate the presence of a correlation between the characteristics of demyelinating lesions and performance of basic executive functions in a sample of MS patients. Material and methods: We included 21 adult patients with scores of 0 to 5 on the Kurtzke scale and no exacerbations of the disease in at least 3 months prior to the evaluation date. They completed the Stroop test and the Wisconsin Card Sorting Test (WCST). The location of the lesions was determined using magnetic resonance imaging (MRI) performed by a blinded expert in neuroimaging. Results: Demyelinating lesions were more frequently located in the frontal and occipital lobes. The Stroop test showed that as cognitive demand increased on each of the sections in the test, reaction time and number of errors increased. On the WCST, 33.33% of patients registered as having moderate cognitive impairment. No correlation could be found between demyelinating lesion characteristics (location, size, and number) and patients’ scores on the tests. Conclusion: Explanations of the causes of cognitive impairment in MS should examine a variety of biological, psychological, and social factors instead of focusing solely on demyelinating lesions. Resumen: Antecedentes: La Esclerosis Múltiple (EM) se caracteriza por una gran diversidad de síntomas neurológicos de entre los cuales el deterioro cognitivo recientemente ha cobrado una especial relevancia. Hasta el momento la evidencia acerca de una correlación entre las características de las lesiones y el deterioro cognitivo específico aún no es concluyente. Objetivo: Analizar si existe una correlación entre las características de las lesiones desmielinizantes y el desempeño de las funciones ejecutivas básicas en estos pacientes. Pacientes y Métodos: Se incluyeron 21 pacientes adultos con puntaje de 0-5 en la escala de Kurtzke, sin exacerbaciones de la enfermedad en los 3 meses previos a la evaluación. Se les aplicaron las pruebas de Stroop, y el Wisconsin Card Sorting Test (WCST). La localización de las lesiones fue determinada por Resonancia Magnética por un observador experto y cegado Resultados: Las lesiones desmielinizantes se distribuyeron con mayor frecuencia en los lóbulos occipitales y frontales. En el Stroop se observó que, a medida que se incrementa la demanda cognitiva en cada sección de la prueba, aumentan el tiempo de reacción y el número de errores. En el WCST, un 33.33% presentó un deterioro medio a moderado. No se encontró una relación entre la lesiones desmielinizantes – localización, tamaño y suma total – y los puntajes de las pruebas aplicadas. Conclusión: En la explicación del deterioro cognitivo en la EM, se deben considerar no sólo a las lesiones desmielinizantes sino también otros factores biológicos, psicológicos y sociales. Keywords: Multiple sclerosis, Cognitive impairment, Executive functions, Demyelinating lesions, Neuropsychology, Mexico, Palabras clave: Esclerosis múltiple, Deterioro cognitivo, Funciones ejecutivas, Lesiones desmielinizantes, Neuropsicología, Méxicohttp://www.sciencedirect.com/science/article/pii/S217358081300120X |
| spellingShingle | V.R. Aldrete Cortez E. Duriez-Sotelo P. Carrillo-Mora J.A. Pérez-Zuno Correlation between demyelinating lesions and executive function decline in a sample of Mexican patients with multiple sclerosis Neurología (English Edition) |
| title | Correlation between demyelinating lesions and executive function decline in a sample of Mexican patients with multiple sclerosis |
| title_full | Correlation between demyelinating lesions and executive function decline in a sample of Mexican patients with multiple sclerosis |
| title_fullStr | Correlation between demyelinating lesions and executive function decline in a sample of Mexican patients with multiple sclerosis |
| title_full_unstemmed | Correlation between demyelinating lesions and executive function decline in a sample of Mexican patients with multiple sclerosis |
| title_short | Correlation between demyelinating lesions and executive function decline in a sample of Mexican patients with multiple sclerosis |
| title_sort | correlation between demyelinating lesions and executive function decline in a sample of mexican patients with multiple sclerosis |
| url | http://www.sciencedirect.com/science/article/pii/S217358081300120X |
| work_keys_str_mv | AT vraldretecortez correlationbetweendemyelinatinglesionsandexecutivefunctiondeclineinasampleofmexicanpatientswithmultiplesclerosis AT eduriezsotelo correlationbetweendemyelinatinglesionsandexecutivefunctiondeclineinasampleofmexicanpatientswithmultiplesclerosis AT pcarrillomora correlationbetweendemyelinatinglesionsandexecutivefunctiondeclineinasampleofmexicanpatientswithmultiplesclerosis AT japerezzuno correlationbetweendemyelinatinglesionsandexecutivefunctiondeclineinasampleofmexicanpatientswithmultiplesclerosis |