Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry study
Objective: Investigate global and regional grey and white matter volumes in patients with Chronic Fatigue Syndrome (CFS) using magnetic resonance imaging (MRI) and recent voxel-based morphometry (VBM) methods. Methods: Forty-two patients with CFS and thirty healthy volunteers were scanned on a 3-Tes...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221315821730236X |
| _version_ | 1819128235469832192 |
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| author | Andreas Finkelmeyer Jiabao He Laura Maclachlan Stuart Watson Peter Gallagher Julia L. Newton Andrew M. Blamire |
| author_facet | Andreas Finkelmeyer Jiabao He Laura Maclachlan Stuart Watson Peter Gallagher Julia L. Newton Andrew M. Blamire |
| author_sort | Andreas Finkelmeyer |
| collection | DOAJ |
| description | Objective: Investigate global and regional grey and white matter volumes in patients with Chronic Fatigue Syndrome (CFS) using magnetic resonance imaging (MRI) and recent voxel-based morphometry (VBM) methods. Methods: Forty-two patients with CFS and thirty healthy volunteers were scanned on a 3-Tesla MRI scanner. Anatomical MRI scans were segmented, normalized and submitted to a VBM analysis using randomisation methods. Group differences were identified in overall segment volumes and voxel-wise in spatially normalized grey matter (GM) and white matter (WM) segments. Results: Accounting for total intracranial volume, patients had larger GM volume and lower WM volume. The voxel-wise analysis showed increased GM volume in several structures including the amygdala and insula in the patient group. Reductions in WM volume in the patient group were seen primarily in the midbrain, pons and right temporal lobe. Conclusion: Elevated GM volume in CFS is seen in areas related to processing of interoceptive signals and stress. Reduced WM volume in the patient group partially supports earlier findings of WM abnormalities in regions of the midbrain and brainstem. Keywords: Chronic Fatigue Syndrome, Voxel-based morphometry, Insula, Amygdala, Midbrain |
| first_indexed | 2024-12-22T08:24:36Z |
| format | Article |
| id | doaj.art-e95ed20db28b4eb8bb7e158800fb05ab |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-22T08:24:36Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-e95ed20db28b4eb8bb7e158800fb05ab2022-12-21T18:32:40ZengElsevierNeuroImage: Clinical2213-15822018-01-01172430Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry studyAndreas Finkelmeyer0Jiabao He1Laura Maclachlan2Stuart Watson3Peter Gallagher4Julia L. Newton5Andrew M. Blamire6Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, England, UK; Corresponding author at: Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.Aberdeen Biomedical Imaging Centre, University of Aberdeen, Scotland, UKDepartment of Public Health and Community Medicine, Göteborgs Universitet, Göteborg, SwedenInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, England, UKInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, England, UKInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, England, UKNewcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, England, UKObjective: Investigate global and regional grey and white matter volumes in patients with Chronic Fatigue Syndrome (CFS) using magnetic resonance imaging (MRI) and recent voxel-based morphometry (VBM) methods. Methods: Forty-two patients with CFS and thirty healthy volunteers were scanned on a 3-Tesla MRI scanner. Anatomical MRI scans were segmented, normalized and submitted to a VBM analysis using randomisation methods. Group differences were identified in overall segment volumes and voxel-wise in spatially normalized grey matter (GM) and white matter (WM) segments. Results: Accounting for total intracranial volume, patients had larger GM volume and lower WM volume. The voxel-wise analysis showed increased GM volume in several structures including the amygdala and insula in the patient group. Reductions in WM volume in the patient group were seen primarily in the midbrain, pons and right temporal lobe. Conclusion: Elevated GM volume in CFS is seen in areas related to processing of interoceptive signals and stress. Reduced WM volume in the patient group partially supports earlier findings of WM abnormalities in regions of the midbrain and brainstem. Keywords: Chronic Fatigue Syndrome, Voxel-based morphometry, Insula, Amygdala, Midbrainhttp://www.sciencedirect.com/science/article/pii/S221315821730236X |
| spellingShingle | Andreas Finkelmeyer Jiabao He Laura Maclachlan Stuart Watson Peter Gallagher Julia L. Newton Andrew M. Blamire Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry study NeuroImage: Clinical |
| title | Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry study |
| title_full | Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry study |
| title_fullStr | Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry study |
| title_full_unstemmed | Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry study |
| title_short | Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry study |
| title_sort | grey and white matter differences in chronic fatigue syndrome a voxel based morphometry study |
| url | http://www.sciencedirect.com/science/article/pii/S221315821730236X |
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