Gitelman syndrome misdiagnosed as Sjögren’s syndrome: a case report
This article reported a 38-year-old female patient who was misdiagnosed as Sjögren’s syndrome complicated with type I distal renal tubular acidosis （dRTA） due to recurrent hypokalemia, alkaline urine, elevated urinary potassium, positive antinuclear body（ANA）, and positive an...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of New Medicine
2022-07-01
|
| Series: | Xin yixue |
| Subjects: | |
| Online Access: | https://www.xinyixue.cn/fileup/0253-9802/PDF/1659601447159-1973410039.pdf |
| _version_ | 1811213181502095360 |
|---|---|
| author | Zeng Wencheng, Li Xiaojuan, Luo Jiahuan, Li Qianhua, Sun Kan, Dai Lie, Mo Yingqian |
| author_facet | Zeng Wencheng, Li Xiaojuan, Luo Jiahuan, Li Qianhua, Sun Kan, Dai Lie, Mo Yingqian |
| author_sort | Zeng Wencheng, Li Xiaojuan, Luo Jiahuan, Li Qianhua, Sun Kan, Dai Lie, Mo Yingqian |
| collection | DOAJ |
| description | This article reported a 38-year-old female patient who was misdiagnosed as Sjögren’s syndrome complicated with type I distal renal tubular acidosis （dRTA） due to recurrent hypokalemia, alkaline urine, elevated urinary potassium, positive antinuclear body（ANA）, and positive anti-SSA antibody. The diagnosis of Sjögren’s syndrome was then excluded because the patient had no obvious dry mouth or dry eyes, and the results of unstimulating saliva flow rate, corneal fluorescence staining, Schirmer secretion test, or labial gland biopsy were all negative. The clinical manifestations, such as metabolic alkalosis, hypochloremia, hypomagnesemia and low urinary calcium,could not support the diagnosis of dRTA. The patient presented with severe hypomagnesemia and a Trousseau sign, then Gitelman syndrome was finally confirmed based on genetic testing. Therefore, the diagnosis and treatment of this case prompted that for patients with recurrent hypokalemia and positive anti-SSA antibody, clinicians should make differential diagnosis based on the acid-base imbalance and the electrolyte disturbance at first, instead of paying too much attention to autoantibodies and Sjögren’s syndrome, to avoid being misled by the ANA and anti-SSA antibody. |
| first_indexed | 2024-04-12T05:41:33Z |
| format | Article |
| id | doaj.art-e95f5d5e04a34fcfadee2aed51dff2bb |
| institution | Directory Open Access Journal |
| issn | 0253-9802 |
| language | zho |
| last_indexed | 2024-04-12T05:41:33Z |
| publishDate | 2022-07-01 |
| publisher | Editorial Office of Journal of New Medicine |
| record_format | Article |
| series | Xin yixue |
| spelling | doaj.art-e95f5d5e04a34fcfadee2aed51dff2bb2022-12-22T03:45:38ZzhoEditorial Office of Journal of New MedicineXin yixue0253-98022022-07-0153752853210.3969/j.issn.0253-9802.2022.07.012Gitelman syndrome misdiagnosed as Sjögren’s syndrome: a case reportZeng Wencheng, Li Xiaojuan, Luo Jiahuan, Li Qianhua, Sun Kan, Dai Lie, Mo Yingqian0△Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, ChinaThis article reported a 38-year-old female patient who was misdiagnosed as Sjögren’s syndrome complicated with type I distal renal tubular acidosis （dRTA） due to recurrent hypokalemia, alkaline urine, elevated urinary potassium, positive antinuclear body（ANA）, and positive anti-SSA antibody. The diagnosis of Sjögren’s syndrome was then excluded because the patient had no obvious dry mouth or dry eyes, and the results of unstimulating saliva flow rate, corneal fluorescence staining, Schirmer secretion test, or labial gland biopsy were all negative. The clinical manifestations, such as metabolic alkalosis, hypochloremia, hypomagnesemia and low urinary calcium,could not support the diagnosis of dRTA. The patient presented with severe hypomagnesemia and a Trousseau sign, then Gitelman syndrome was finally confirmed based on genetic testing. Therefore, the diagnosis and treatment of this case prompted that for patients with recurrent hypokalemia and positive anti-SSA antibody, clinicians should make differential diagnosis based on the acid-base imbalance and the electrolyte disturbance at first, instead of paying too much attention to autoantibodies and Sjögren’s syndrome, to avoid being misled by the ANA and anti-SSA antibody.https://www.xinyixue.cn/fileup/0253-9802/PDF/1659601447159-1973410039.pdf|gitelman syndrome|hypokalemia|sjögren’s syndrome|anti-ssa antibody|ana |
| spellingShingle | Zeng Wencheng, Li Xiaojuan, Luo Jiahuan, Li Qianhua, Sun Kan, Dai Lie, Mo Yingqian Gitelman syndrome misdiagnosed as Sjögren’s syndrome: a case report Xin yixue |gitelman syndrome|hypokalemia|sjögren’s syndrome|anti-ssa antibody|ana |
| title | Gitelman syndrome misdiagnosed as Sjögren’s syndrome: a case report |
| title_full | Gitelman syndrome misdiagnosed as Sjögren’s syndrome: a case report |
| title_fullStr | Gitelman syndrome misdiagnosed as Sjögren’s syndrome: a case report |
| title_full_unstemmed | Gitelman syndrome misdiagnosed as Sjögren’s syndrome: a case report |
| title_short | Gitelman syndrome misdiagnosed as Sjögren’s syndrome: a case report |
| title_sort | gitelman syndrome misdiagnosed as sj x000f6 gren x02019 s syndrome a case report |
| topic | |gitelman syndrome|hypokalemia|sjögren’s syndrome|anti-ssa antibody|ana |
| url | https://www.xinyixue.cn/fileup/0253-9802/PDF/1659601447159-1973410039.pdf |
| work_keys_str_mv | AT zengwenchenglixiaojuanluojiahuanliqianhuasunkandailiemoyingqian gitelmansyndromemisdiagnosedassjx000f6grenx02019ssyndromeacasereport |