Association of adverse childhood experiences with lipid profiles and atherogenic risk indices in a middle-to-older aged population
Background: Adverse childhood experiences (ACE) have been associated with poor later life health outcomes, including cardiovascular disease (CVD). Limited research investigating potential underlying biological mechanisms linking ACE to CVD exists, particularly regarding lipid biomarkers. Objectives:...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | SSM: Population Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352827323000587 |
| _version_ | 1797823736010768384 |
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| author | Emily O'Leary Seán R. Millar Ivan J. Perry Catherine M. Phillips |
| author_facet | Emily O'Leary Seán R. Millar Ivan J. Perry Catherine M. Phillips |
| author_sort | Emily O'Leary |
| collection | DOAJ |
| description | Background: Adverse childhood experiences (ACE) have been associated with poor later life health outcomes, including cardiovascular disease (CVD). Limited research investigating potential underlying biological mechanisms linking ACE to CVD exists, particularly regarding lipid biomarkers. Objectives: The aim of this study was to examine the associations between childhood adversity and unfavourable lipid profiles and derived atherogenic risk indices in a middle-to-older aged population. Methods: This cross-sectional study includes 1820 participants from the Mitchelstown cohort (49% male) in Ireland. Participants' self-reported history of childhood adversity (overall and by subtypes household dysfunction, abuse and neglect) were assessed through a validated 10-item ACE questionnaire. Lipid profiles were determined and atherogenic risk indices including Castelli's Risk Index 1 and 2 (CRI-I and CRI-II), Atherogenic Coefficient (AC) and Atherogenic Index Plasma (AIP) were generated. Logistic regression analysed ACE associations with unfavourable lipid outcomes, controlling for potential confounders. Results: ACE history (reported by 23% of sample), in particular childhood exposure to household dysfunction, was associated with later-life non-optimal TG and HDL-C concentrations and atherogenic risk indices CRI-II and AC in age and sex-adjusted models (all p < 0.05). In fully adjusted models, adults reporting ACE or exposure to household dysfunction were approximately twice as likely to have pro-atherogenic CRI-II relative to adults with no ACE (OR = 1.86, 95% CI: 1.19–2.92, p = 0.006 and OR = 2.19, 95% CI: 1.33–3.61, p = 0.002, respectively). Sex-stratified analysis demonstrated sex-specific associations. Conclusions: This study provides evidence that ACEs are common among older adults in Ireland and are associated with unfavourable lipid profiles and derived atherogenic risk indices. |
| first_indexed | 2024-03-13T10:28:24Z |
| format | Article |
| id | doaj.art-e95fd5b759f44defaff5c50514606815 |
| institution | Directory Open Access Journal |
| issn | 2352-8273 |
| language | English |
| last_indexed | 2024-03-13T10:28:24Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | SSM: Population Health |
| spelling | doaj.art-e95fd5b759f44defaff5c505146068152023-05-19T04:45:50ZengElsevierSSM: Population Health2352-82732023-06-0122101393Association of adverse childhood experiences with lipid profiles and atherogenic risk indices in a middle-to-older aged populationEmily O'Leary0Seán R. Millar1Ivan J. Perry2Catherine M. Phillips3School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin 4, IrelandSchool of Public Health, University College Cork, Cork, IrelandSchool of Public Health, University College Cork, Cork, IrelandSchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin 4, Ireland; Corresponding author. School of Public Health, Physiotherapy and Sports Science, University College Dublin, Ireland.Background: Adverse childhood experiences (ACE) have been associated with poor later life health outcomes, including cardiovascular disease (CVD). Limited research investigating potential underlying biological mechanisms linking ACE to CVD exists, particularly regarding lipid biomarkers. Objectives: The aim of this study was to examine the associations between childhood adversity and unfavourable lipid profiles and derived atherogenic risk indices in a middle-to-older aged population. Methods: This cross-sectional study includes 1820 participants from the Mitchelstown cohort (49% male) in Ireland. Participants' self-reported history of childhood adversity (overall and by subtypes household dysfunction, abuse and neglect) were assessed through a validated 10-item ACE questionnaire. Lipid profiles were determined and atherogenic risk indices including Castelli's Risk Index 1 and 2 (CRI-I and CRI-II), Atherogenic Coefficient (AC) and Atherogenic Index Plasma (AIP) were generated. Logistic regression analysed ACE associations with unfavourable lipid outcomes, controlling for potential confounders. Results: ACE history (reported by 23% of sample), in particular childhood exposure to household dysfunction, was associated with later-life non-optimal TG and HDL-C concentrations and atherogenic risk indices CRI-II and AC in age and sex-adjusted models (all p < 0.05). In fully adjusted models, adults reporting ACE or exposure to household dysfunction were approximately twice as likely to have pro-atherogenic CRI-II relative to adults with no ACE (OR = 1.86, 95% CI: 1.19–2.92, p = 0.006 and OR = 2.19, 95% CI: 1.33–3.61, p = 0.002, respectively). Sex-stratified analysis demonstrated sex-specific associations. Conclusions: This study provides evidence that ACEs are common among older adults in Ireland and are associated with unfavourable lipid profiles and derived atherogenic risk indices.http://www.sciencedirect.com/science/article/pii/S2352827323000587Cardiovascular diseaseAdverse childhood experiencesLipid biomarkersCholesterolAtherogenic risk indices |
| spellingShingle | Emily O'Leary Seán R. Millar Ivan J. Perry Catherine M. Phillips Association of adverse childhood experiences with lipid profiles and atherogenic risk indices in a middle-to-older aged population SSM: Population Health Cardiovascular disease Adverse childhood experiences Lipid biomarkers Cholesterol Atherogenic risk indices |
| title | Association of adverse childhood experiences with lipid profiles and atherogenic risk indices in a middle-to-older aged population |
| title_full | Association of adverse childhood experiences with lipid profiles and atherogenic risk indices in a middle-to-older aged population |
| title_fullStr | Association of adverse childhood experiences with lipid profiles and atherogenic risk indices in a middle-to-older aged population |
| title_full_unstemmed | Association of adverse childhood experiences with lipid profiles and atherogenic risk indices in a middle-to-older aged population |
| title_short | Association of adverse childhood experiences with lipid profiles and atherogenic risk indices in a middle-to-older aged population |
| title_sort | association of adverse childhood experiences with lipid profiles and atherogenic risk indices in a middle to older aged population |
| topic | Cardiovascular disease Adverse childhood experiences Lipid biomarkers Cholesterol Atherogenic risk indices |
| url | http://www.sciencedirect.com/science/article/pii/S2352827323000587 |
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