Neurologic sequelae of severe chikungunya infection in the first 6 months of life: a prospective cohort study 24-months post-infection
Abstract Background Perinatally chikungunya infected neonates have been reported to have high rates of post-infection neurologic sequelae, mainly cognitive problems. In older children and adults chikungunya does not appear to have sequelae, but data on postnatally infected infants are lacking. Metho...
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-021-05876-4 |
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| author | Roelof van Ewijk Minke H. W. Huibers Meindert E. Manshande Ginette M. Ecury-Goossen Ashley J. Duits Job C. Calis Aleid G. van Wassenaer-Leemhuis |
| author_facet | Roelof van Ewijk Minke H. W. Huibers Meindert E. Manshande Ginette M. Ecury-Goossen Ashley J. Duits Job C. Calis Aleid G. van Wassenaer-Leemhuis |
| author_sort | Roelof van Ewijk |
| collection | DOAJ |
| description | Abstract Background Perinatally chikungunya infected neonates have been reported to have high rates of post-infection neurologic sequelae, mainly cognitive problems. In older children and adults chikungunya does not appear to have sequelae, but data on postnatally infected infants are lacking. Methods We performed a prospective, non-controlled, observational study of infants infected before the age of 6 months with a severe chikungunya infection during the 2014–2015 epidemic in Curaçao, Dutch Antilles. Two years post-infection cognitive and motor - (BSID-III) and social emotional assessments (ITSEA) were performed. Results Of twenty-two infected infants, two died and two were lost to follow up. Eighteen children were seen at follow-up and included in the current study. Of these, 13 (72%) had abnormal scores on the BSID-III (cognitive/motor) or ITSEA. Conclusion In the first study aimed at postnatally infected infants, using an uncontrolled design, we observed a very high percentage of developmental problems. Further studies are needed to assess causality, however until these data are available preventive measure during outbreaks should also include young infants. Those that have been infected in early infancy should receive follow up. |
| first_indexed | 2024-12-16T14:36:44Z |
| format | Article |
| id | doaj.art-e960b71c59b4412382097872bba40e7a |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-16T14:36:44Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-e960b71c59b4412382097872bba40e7a2022-12-21T22:28:04ZengBMCBMC Infectious Diseases1471-23342021-02-012111810.1186/s12879-021-05876-4Neurologic sequelae of severe chikungunya infection in the first 6 months of life: a prospective cohort study 24-months post-infectionRoelof van Ewijk0Minke H. W. Huibers1Meindert E. Manshande2Ginette M. Ecury-Goossen3Ashley J. Duits4Job C. Calis5Aleid G. van Wassenaer-Leemhuis6Saint Elisabeth HospitalEmma Children’s Hospital, Amsterdam UMC, University of AmsterdamSaint Elisabeth HospitalSaint Elisabeth HospitalSaint Elisabeth HospitalEmma Children’s Hospital, Amsterdam UMC, University of AmsterdamEmma Children’s Hospital, Amsterdam UMC, University of AmsterdamAbstract Background Perinatally chikungunya infected neonates have been reported to have high rates of post-infection neurologic sequelae, mainly cognitive problems. In older children and adults chikungunya does not appear to have sequelae, but data on postnatally infected infants are lacking. Methods We performed a prospective, non-controlled, observational study of infants infected before the age of 6 months with a severe chikungunya infection during the 2014–2015 epidemic in Curaçao, Dutch Antilles. Two years post-infection cognitive and motor - (BSID-III) and social emotional assessments (ITSEA) were performed. Results Of twenty-two infected infants, two died and two were lost to follow up. Eighteen children were seen at follow-up and included in the current study. Of these, 13 (72%) had abnormal scores on the BSID-III (cognitive/motor) or ITSEA. Conclusion In the first study aimed at postnatally infected infants, using an uncontrolled design, we observed a very high percentage of developmental problems. Further studies are needed to assess causality, however until these data are available preventive measure during outbreaks should also include young infants. Those that have been infected in early infancy should receive follow up.https://doi.org/10.1186/s12879-021-05876-4Chikungunya virusNeurologic manifestationsChild developmentAlphavirus infectionsInfantInfant, Newborn, diseases |
| spellingShingle | Roelof van Ewijk Minke H. W. Huibers Meindert E. Manshande Ginette M. Ecury-Goossen Ashley J. Duits Job C. Calis Aleid G. van Wassenaer-Leemhuis Neurologic sequelae of severe chikungunya infection in the first 6 months of life: a prospective cohort study 24-months post-infection BMC Infectious Diseases Chikungunya virus Neurologic manifestations Child development Alphavirus infections Infant Infant, Newborn, diseases |
| title | Neurologic sequelae of severe chikungunya infection in the first 6 months of life: a prospective cohort study 24-months post-infection |
| title_full | Neurologic sequelae of severe chikungunya infection in the first 6 months of life: a prospective cohort study 24-months post-infection |
| title_fullStr | Neurologic sequelae of severe chikungunya infection in the first 6 months of life: a prospective cohort study 24-months post-infection |
| title_full_unstemmed | Neurologic sequelae of severe chikungunya infection in the first 6 months of life: a prospective cohort study 24-months post-infection |
| title_short | Neurologic sequelae of severe chikungunya infection in the first 6 months of life: a prospective cohort study 24-months post-infection |
| title_sort | neurologic sequelae of severe chikungunya infection in the first 6 months of life a prospective cohort study 24 months post infection |
| topic | Chikungunya virus Neurologic manifestations Child development Alphavirus infections Infant Infant, Newborn, diseases |
| url | https://doi.org/10.1186/s12879-021-05876-4 |
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