Mutation-driven evolution of antibacterial function in an ancestral antifungal scaffold: Significance for peptide engineering

Mutation-driven evolution of antibacterial function in an ancestral antifungal scaffold: Significance for peptide engineering

Mutation-driven evolution of novel function on an old gene has been documented in many development- and adaptive immunity-related genes but is poorly understood in immune effector molecules. Drosomycin-type antifungal peptides (DTAFPs) are a family of defensin-type effectors found in plants and ecdy...

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Bibliographic Details
Main Authors: Jing Gu, Noriyoshi Isozumi, Bin Gao, Shinya Ohki, Shunyi Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Microbiology
Subjects:
drosomycin
mehamycin
nematode
co-option
allostery
deletion mutant
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1053078/full

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