Engineered Cell Membrane-Camouflaged Nanomaterials for Biomedical Applications
Recent strides in nanomaterials science have paved the way for the creation of reliable, effective, highly accurate, and user-friendly biomedical systems. Pioneering the integration of natural cell membranes into sophisticated nanocarrier architectures, cell membrane camouflage has emerged as a tran...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/14/5/413 |
| _version_ | 1797264122513981440 |
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| author | Xiyuan Guan Simin Xing Yang Liu |
| author_facet | Xiyuan Guan Simin Xing Yang Liu |
| author_sort | Xiyuan Guan |
| collection | DOAJ |
| description | Recent strides in nanomaterials science have paved the way for the creation of reliable, effective, highly accurate, and user-friendly biomedical systems. Pioneering the integration of natural cell membranes into sophisticated nanocarrier architectures, cell membrane camouflage has emerged as a transformative approach for regulated drug delivery, offering the benefits of minimal immunogenicity coupled with active targeting capabilities. Nevertheless, the utility of nanomaterials with such camouflage is curtailed by challenges like suboptimal targeting precision and lackluster therapeutic efficacy. Tailored cell membrane engineering stands at the forefront of biomedicine, equipping nanoplatforms with the capacity to conduct more complex operations. This review commences with an examination of prevailing methodologies in cell membrane engineering, spotlighting strategies such as direct chemical modification, lipid insertion, membrane hybridization, metabolic glycan labeling, and genetic engineering. Following this, an evaluation of the unique attributes of various nanomaterials is presented, delivering an in-depth scrutiny of the substantial advancements and applications driven by cutting-edge engineered cell membrane camouflage. The discourse culminates by recapitulating the salient influence of engineered cell membrane camouflage within nanomaterial applications and prognosticates its seminal role in transformative healthcare technologies. It is envisaged that the insights offered herein will catalyze novel avenues for the innovation and refinement of engineered cell membrane camouflaged nanotechnologies. |
| first_indexed | 2024-04-25T00:23:53Z |
| format | Article |
| id | doaj.art-e963d20d7f9448a7bbc305d4ad1891d6 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-04-25T00:23:53Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-e963d20d7f9448a7bbc305d4ad1891d62024-03-12T16:51:30ZengMDPI AGNanomaterials2079-49912024-02-0114541310.3390/nano14050413Engineered Cell Membrane-Camouflaged Nanomaterials for Biomedical ApplicationsXiyuan Guan0Simin Xing1Yang Liu2Department of Chemistry, Beijing Key Laboratory for Analytical Methods and Instrumentation, Kay Lab of Bioorganic Phosphorus Chemistry and Chemical Biology of Ministry of Education, Tsinghua University, Beijing 100084, ChinaDepartment of Chemistry, Beijing Key Laboratory for Analytical Methods and Instrumentation, Kay Lab of Bioorganic Phosphorus Chemistry and Chemical Biology of Ministry of Education, Tsinghua University, Beijing 100084, ChinaDepartment of Chemistry, Beijing Key Laboratory for Analytical Methods and Instrumentation, Kay Lab of Bioorganic Phosphorus Chemistry and Chemical Biology of Ministry of Education, Tsinghua University, Beijing 100084, ChinaRecent strides in nanomaterials science have paved the way for the creation of reliable, effective, highly accurate, and user-friendly biomedical systems. Pioneering the integration of natural cell membranes into sophisticated nanocarrier architectures, cell membrane camouflage has emerged as a transformative approach for regulated drug delivery, offering the benefits of minimal immunogenicity coupled with active targeting capabilities. Nevertheless, the utility of nanomaterials with such camouflage is curtailed by challenges like suboptimal targeting precision and lackluster therapeutic efficacy. Tailored cell membrane engineering stands at the forefront of biomedicine, equipping nanoplatforms with the capacity to conduct more complex operations. This review commences with an examination of prevailing methodologies in cell membrane engineering, spotlighting strategies such as direct chemical modification, lipid insertion, membrane hybridization, metabolic glycan labeling, and genetic engineering. Following this, an evaluation of the unique attributes of various nanomaterials is presented, delivering an in-depth scrutiny of the substantial advancements and applications driven by cutting-edge engineered cell membrane camouflage. The discourse culminates by recapitulating the salient influence of engineered cell membrane camouflage within nanomaterial applications and prognosticates its seminal role in transformative healthcare technologies. It is envisaged that the insights offered herein will catalyze novel avenues for the innovation and refinement of engineered cell membrane camouflaged nanotechnologies.https://www.mdpi.com/2079-4991/14/5/413engineered cell membranecell membrane-camouflaged nanomaterialslong circulation timeactive targetingbiomedical applications |
| spellingShingle | Xiyuan Guan Simin Xing Yang Liu Engineered Cell Membrane-Camouflaged Nanomaterials for Biomedical Applications Nanomaterials engineered cell membrane cell membrane-camouflaged nanomaterials long circulation time active targeting biomedical applications |
| title | Engineered Cell Membrane-Camouflaged Nanomaterials for Biomedical Applications |
| title_full | Engineered Cell Membrane-Camouflaged Nanomaterials for Biomedical Applications |
| title_fullStr | Engineered Cell Membrane-Camouflaged Nanomaterials for Biomedical Applications |
| title_full_unstemmed | Engineered Cell Membrane-Camouflaged Nanomaterials for Biomedical Applications |
| title_short | Engineered Cell Membrane-Camouflaged Nanomaterials for Biomedical Applications |
| title_sort | engineered cell membrane camouflaged nanomaterials for biomedical applications |
| topic | engineered cell membrane cell membrane-camouflaged nanomaterials long circulation time active targeting biomedical applications |
| url | https://www.mdpi.com/2079-4991/14/5/413 |
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