Causes of Elevated Levels of Serum CA 19.9 in Patients without Prior Diagnosis of Malignant Disease
INTRODUCTION[|]Serum CA 19.9 is commonly used as a tumor marker for diagnosis and follow-up of gastrointestinal malignancies. However, elevated levels can be found in various clinical conditions.[¤]METHODS[|]A total of 285 patients whose serum CA 19.9 level was ordered from various outpatient clinic...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2019-09-01
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| Series: | Southern Clinics of Istanbul Eurasia |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-82905 |
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| author | Selcuk Şeber Savaş Güzel Ahsen Yılmaz Sonat Pınar Kara Tarkan Yetisyigit |
| author_facet | Selcuk Şeber Savaş Güzel Ahsen Yılmaz Sonat Pınar Kara Tarkan Yetisyigit |
| author_sort | Selcuk Şeber |
| collection | DOAJ |
| description | INTRODUCTION[|]Serum CA 19.9 is commonly used as a tumor marker for diagnosis and follow-up of gastrointestinal malignancies. However, elevated levels can be found in various clinical conditions.[¤]METHODS[|]A total of 285 patients whose serum CA 19.9 level was ordered from various outpatient clinics other than oncology in a tertiary hospital setting and who had elevated CA 19.9 (>34 U/mL) levels were included in the study group. Statistical analysis of marker levels in relation to diagnosis of patients was performed.[¤]RESULTS[|]Overall, 226 patients with benign disorders and 59 patients with malignant disease had elevated CA 19-9 levels. One hundred ten (39%) patients with increased CA 19-9 levels did not have any significant clinical condition associated with high CA 19-9 values. Median CA 19-9 levels were significantly higher in patients with malignancies than in patients with benign disorders (67.3 vs. 47.9; p<0.001). Receiver operating characteristic curve analysis identified a cut-off value of 66.3 U/mL for discrimination of malignant from benign gastrointestinal diseases (sensitivity 58.3% and specificity 82.7%; p<0.001).[¤]DISCUSSION AND CONCLUSION[|]Serum CA 19-9 levels are significantly higher in patients with malignant diseases. However, there are diverse etiologies associated with elevated serum levels. During chronic inflammatory states, elevated serum CA 19-9 levels can be a frequent finding.[¤] |
| first_indexed | 2024-04-10T11:55:22Z |
| format | Article |
| id | doaj.art-e96528a8101c4e10932cc25cc097800e |
| institution | Directory Open Access Journal |
| issn | 2587-0998 |
| language | English |
| last_indexed | 2024-04-10T11:55:22Z |
| publishDate | 2019-09-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Southern Clinics of Istanbul Eurasia |
| spelling | doaj.art-e96528a8101c4e10932cc25cc097800e2023-02-15T16:16:51ZengKARE PublishingSouthern Clinics of Istanbul Eurasia2587-09982019-09-0130319820310.14744/scie.2019.82905SCIE-82905Causes of Elevated Levels of Serum CA 19.9 in Patients without Prior Diagnosis of Malignant DiseaseSelcuk Şeber0Savaş Güzel1Ahsen Yılmaz2Sonat Pınar Kara3Tarkan Yetisyigit4Department of Medical Oncology, Namık Kemal University Hospital, Tekirdağ, TurkeyDepartment of Internal Medicine, Namık Kemal University Hospital, Tekirdağ, TurkeyDepartment of Internal Medicine, Namık Kemal University Hospital, Tekirdağ, TurkeyDepartment of Medical Biochemistry, Namık Kemal University Hospital, Tekirdağ, TurkeyDepartment of Medical Oncology, Namık Kemal University Hospital, Tekirdağ, TurkeyINTRODUCTION[|]Serum CA 19.9 is commonly used as a tumor marker for diagnosis and follow-up of gastrointestinal malignancies. However, elevated levels can be found in various clinical conditions.[¤]METHODS[|]A total of 285 patients whose serum CA 19.9 level was ordered from various outpatient clinics other than oncology in a tertiary hospital setting and who had elevated CA 19.9 (>34 U/mL) levels were included in the study group. Statistical analysis of marker levels in relation to diagnosis of patients was performed.[¤]RESULTS[|]Overall, 226 patients with benign disorders and 59 patients with malignant disease had elevated CA 19-9 levels. One hundred ten (39%) patients with increased CA 19-9 levels did not have any significant clinical condition associated with high CA 19-9 values. Median CA 19-9 levels were significantly higher in patients with malignancies than in patients with benign disorders (67.3 vs. 47.9; p<0.001). Receiver operating characteristic curve analysis identified a cut-off value of 66.3 U/mL for discrimination of malignant from benign gastrointestinal diseases (sensitivity 58.3% and specificity 82.7%; p<0.001).[¤]DISCUSSION AND CONCLUSION[|]Serum CA 19-9 levels are significantly higher in patients with malignant diseases. However, there are diverse etiologies associated with elevated serum levels. During chronic inflammatory states, elevated serum CA 19-9 levels can be a frequent finding.[¤]https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-82905ca 19-9inflammation; malignancy. |
| spellingShingle | Selcuk Şeber Savaş Güzel Ahsen Yılmaz Sonat Pınar Kara Tarkan Yetisyigit Causes of Elevated Levels of Serum CA 19.9 in Patients without Prior Diagnosis of Malignant Disease Southern Clinics of Istanbul Eurasia ca 19-9 inflammation; malignancy. |
| title | Causes of Elevated Levels of Serum CA 19.9 in Patients without Prior Diagnosis of Malignant Disease |
| title_full | Causes of Elevated Levels of Serum CA 19.9 in Patients without Prior Diagnosis of Malignant Disease |
| title_fullStr | Causes of Elevated Levels of Serum CA 19.9 in Patients without Prior Diagnosis of Malignant Disease |
| title_full_unstemmed | Causes of Elevated Levels of Serum CA 19.9 in Patients without Prior Diagnosis of Malignant Disease |
| title_short | Causes of Elevated Levels of Serum CA 19.9 in Patients without Prior Diagnosis of Malignant Disease |
| title_sort | causes of elevated levels of serum ca 19 9 in patients without prior diagnosis of malignant disease |
| topic | ca 19-9 inflammation; malignancy. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-82905 |
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