Cognitive load associates prolonged P300 latency during target stimulus processing in individuals with mild cognitive impairment
Abstract Alterations in P300 amplitude and latency, as well as neuropsychological tests, are informative to detect early signs of the affected high cognitive processing in Mild Cognitive Impairment (MCI). In the present study, we examined P300 latency and amplitude elicited by visual oddball paradig...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-09-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-43132-8 |
| _version_ | 1827723340903612416 |
|---|---|
| author | Pinar Demirayak İlayda Kıyı Yağmur Özbek İşbitiren Görsev Yener |
| author_facet | Pinar Demirayak İlayda Kıyı Yağmur Özbek İşbitiren Görsev Yener |
| author_sort | Pinar Demirayak |
| collection | DOAJ |
| description | Abstract Alterations in P300 amplitude and latency, as well as neuropsychological tests, are informative to detect early signs of the affected high cognitive processing in Mild Cognitive Impairment (MCI). In the present study, we examined P300 latency and amplitude elicited by visual oddball paradigm in 20 participants with MCI and age, education, and sex-matched healthy controls from frontal, central, and parietal midline electrodes. We performed a mixed-design ANOVA to compare P300 amplitude and latency between groups during target and non-target stimulus presentation. We also assessed the correlation between our electrophysiology findings and neuropsychological tests. Our results indicated that in healthy individuals P300 is elicited earlier in target stimulus processing compared to non-target stimulus processing. On the contrary, in the MCI group, P300 latency was increased during target processing compared to non-target stimulus processing. Moreover, P300 latency in target processing is prolonged in the MCI group compared to controls. Also, our correlation results showed a significant correlation between P300 peak latency and amplitude, and attention required cognitive tasks. In conclusion, our results provide evidence that high-order cognitive processes that are involved in stimulus processing slows down in individuals with MCI due to the high working memory demand for neural processing. |
| first_indexed | 2024-03-10T21:58:55Z |
| format | Article |
| id | doaj.art-e96623342e904923b498f036c4d5494f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T21:58:55Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e96623342e904923b498f036c4d5494f2023-11-19T13:01:58ZengNature PortfolioScientific Reports2045-23222023-09-0113111110.1038/s41598-023-43132-8Cognitive load associates prolonged P300 latency during target stimulus processing in individuals with mild cognitive impairmentPinar Demirayak0İlayda Kıyı1Yağmur Özbek İşbitiren2Görsev Yener3Civitan International Research Center, University of Alabama at BirminghamDepartment of Neurosciences, Institute of Health Sciences, Dokuz Eylül UniversityDepartment of Neurosciences, Institute of Health Sciences, Dokuz Eylül UniversityBrain Dynamics Multidisciplinary Research Center, Dokuz Eylül UniversityAbstract Alterations in P300 amplitude and latency, as well as neuropsychological tests, are informative to detect early signs of the affected high cognitive processing in Mild Cognitive Impairment (MCI). In the present study, we examined P300 latency and amplitude elicited by visual oddball paradigm in 20 participants with MCI and age, education, and sex-matched healthy controls from frontal, central, and parietal midline electrodes. We performed a mixed-design ANOVA to compare P300 amplitude and latency between groups during target and non-target stimulus presentation. We also assessed the correlation between our electrophysiology findings and neuropsychological tests. Our results indicated that in healthy individuals P300 is elicited earlier in target stimulus processing compared to non-target stimulus processing. On the contrary, in the MCI group, P300 latency was increased during target processing compared to non-target stimulus processing. Moreover, P300 latency in target processing is prolonged in the MCI group compared to controls. Also, our correlation results showed a significant correlation between P300 peak latency and amplitude, and attention required cognitive tasks. In conclusion, our results provide evidence that high-order cognitive processes that are involved in stimulus processing slows down in individuals with MCI due to the high working memory demand for neural processing.https://doi.org/10.1038/s41598-023-43132-8 |
| spellingShingle | Pinar Demirayak İlayda Kıyı Yağmur Özbek İşbitiren Görsev Yener Cognitive load associates prolonged P300 latency during target stimulus processing in individuals with mild cognitive impairment Scientific Reports |
| title | Cognitive load associates prolonged P300 latency during target stimulus processing in individuals with mild cognitive impairment |
| title_full | Cognitive load associates prolonged P300 latency during target stimulus processing in individuals with mild cognitive impairment |
| title_fullStr | Cognitive load associates prolonged P300 latency during target stimulus processing in individuals with mild cognitive impairment |
| title_full_unstemmed | Cognitive load associates prolonged P300 latency during target stimulus processing in individuals with mild cognitive impairment |
| title_short | Cognitive load associates prolonged P300 latency during target stimulus processing in individuals with mild cognitive impairment |
| title_sort | cognitive load associates prolonged p300 latency during target stimulus processing in individuals with mild cognitive impairment |
| url | https://doi.org/10.1038/s41598-023-43132-8 |
| work_keys_str_mv | AT pinardemirayak cognitiveloadassociatesprolongedp300latencyduringtargetstimulusprocessinginindividualswithmildcognitiveimpairment AT ilaydakıyı cognitiveloadassociatesprolongedp300latencyduringtargetstimulusprocessinginindividualswithmildcognitiveimpairment AT yagmurozbekisbitiren cognitiveloadassociatesprolongedp300latencyduringtargetstimulusprocessinginindividualswithmildcognitiveimpairment AT gorsevyener cognitiveloadassociatesprolongedp300latencyduringtargetstimulusprocessinginindividualswithmildcognitiveimpairment |