Factors associated with the development of oral allergy syndrome: A retrospective questionnaire survey of Japanese university students
Background: Oral allergy syndrome (OAS) is an IgE-mediated food allergy. Ingestion of causative antigens leads to the development of local symptoms such as numbness of the oral mucosa in most cases and anaphylaxis in a few cases. The prevalence of OAS including in healthy people has not been investi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-10-01
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| Series: | Allergology International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893021000150 |
| _version_ | 1818597795708272640 |
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| author | Mai Matsumoto Motoi Takenaka Kiyoshi Aoyagi Yoshihito Tomita Kazuhiko Arima Keiko Yamauchi-Takihara Hiroyuki Murota |
| author_facet | Mai Matsumoto Motoi Takenaka Kiyoshi Aoyagi Yoshihito Tomita Kazuhiko Arima Keiko Yamauchi-Takihara Hiroyuki Murota |
| author_sort | Mai Matsumoto |
| collection | DOAJ |
| description | Background: Oral allergy syndrome (OAS) is an IgE-mediated food allergy. Ingestion of causative antigens leads to the development of local symptoms such as numbness of the oral mucosa in most cases and anaphylaxis in a few cases. The prevalence of OAS including in healthy people has not been investigated. Thus, we conducted a questionnaire survey of Japanese university students. Methods: We conducted a cross-sectional study of 2688 first-year students using a questionnaire survey in marksheet format and examined the epidemiological characteristics of OAS. Results: Only 2.7% of students were aware of the term “oral allergy syndrome”. A total of 143 (5.3%) students had OAS. There were significant associations between OAS and other allergic diseases including allergic rhinitis (AR) (OR: 3.8, 95% CI: 2.7–5.5), atopic dermatitis (AD) (OR: 4.6, 95%CI: 3.3–6.6), and bronchial asthma (BA) (OR: 3.0, 95%CI: 2.0–4.5). The onset age of OAS showed bimodal peaks at 0 and 10 years, and the latter peak coincided with the peak onset age of AR. Conclusions: Awareness of OAS was low in our study, which will make it difficult to treat properly and prevent its development. This survey confirmed the association between OAS and other allergic diseases, especially AR, which suggests that OAS is involved in the allergic march. A novel finding was that sensitization to antigens for OAS occurred around the same time as sensitization to antigens for AR. These results will help medical professionals diagnose OAS and develop lifestyle guidelines to prevent OAS-related symptoms such as anaphylaxis. |
| first_indexed | 2024-12-16T11:53:29Z |
| format | Article |
| id | doaj.art-e9668cecbe164143bf2e6f489178e280 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-16T11:53:29Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-e9668cecbe164143bf2e6f489178e2802022-12-21T22:32:38ZengElsevierAllergology International1323-89302021-10-01704458462Factors associated with the development of oral allergy syndrome: A retrospective questionnaire survey of Japanese university studentsMai Matsumoto0Motoi Takenaka1Kiyoshi Aoyagi2Yoshihito Tomita3Kazuhiko Arima4Keiko Yamauchi-Takihara5Hiroyuki Murota6Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanHealth and Counseling Center, Osaka University, Osaka, JapanDepartment of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Corresponding author. Department of Dermatology, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto-machi, Nagasaki-shi, Nagasaki 852-8523, Japan.Background: Oral allergy syndrome (OAS) is an IgE-mediated food allergy. Ingestion of causative antigens leads to the development of local symptoms such as numbness of the oral mucosa in most cases and anaphylaxis in a few cases. The prevalence of OAS including in healthy people has not been investigated. Thus, we conducted a questionnaire survey of Japanese university students. Methods: We conducted a cross-sectional study of 2688 first-year students using a questionnaire survey in marksheet format and examined the epidemiological characteristics of OAS. Results: Only 2.7% of students were aware of the term “oral allergy syndrome”. A total of 143 (5.3%) students had OAS. There were significant associations between OAS and other allergic diseases including allergic rhinitis (AR) (OR: 3.8, 95% CI: 2.7–5.5), atopic dermatitis (AD) (OR: 4.6, 95%CI: 3.3–6.6), and bronchial asthma (BA) (OR: 3.0, 95%CI: 2.0–4.5). The onset age of OAS showed bimodal peaks at 0 and 10 years, and the latter peak coincided with the peak onset age of AR. Conclusions: Awareness of OAS was low in our study, which will make it difficult to treat properly and prevent its development. This survey confirmed the association between OAS and other allergic diseases, especially AR, which suggests that OAS is involved in the allergic march. A novel finding was that sensitization to antigens for OAS occurred around the same time as sensitization to antigens for AR. These results will help medical professionals diagnose OAS and develop lifestyle guidelines to prevent OAS-related symptoms such as anaphylaxis.http://www.sciencedirect.com/science/article/pii/S1323893021000150Awareness of OASCross-sectional studyOral allergy syndromeQuestionnaire surveyRisk factors |
| spellingShingle | Mai Matsumoto Motoi Takenaka Kiyoshi Aoyagi Yoshihito Tomita Kazuhiko Arima Keiko Yamauchi-Takihara Hiroyuki Murota Factors associated with the development of oral allergy syndrome: A retrospective questionnaire survey of Japanese university students Allergology International Awareness of OAS Cross-sectional study Oral allergy syndrome Questionnaire survey Risk factors |
| title | Factors associated with the development of oral allergy syndrome: A retrospective questionnaire survey of Japanese university students |
| title_full | Factors associated with the development of oral allergy syndrome: A retrospective questionnaire survey of Japanese university students |
| title_fullStr | Factors associated with the development of oral allergy syndrome: A retrospective questionnaire survey of Japanese university students |
| title_full_unstemmed | Factors associated with the development of oral allergy syndrome: A retrospective questionnaire survey of Japanese university students |
| title_short | Factors associated with the development of oral allergy syndrome: A retrospective questionnaire survey of Japanese university students |
| title_sort | factors associated with the development of oral allergy syndrome a retrospective questionnaire survey of japanese university students |
| topic | Awareness of OAS Cross-sectional study Oral allergy syndrome Questionnaire survey Risk factors |
| url | http://www.sciencedirect.com/science/article/pii/S1323893021000150 |
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