Identification of Common and Distinct Pathways in Inflammatory Bowel Disease and Colorectal Cancer: A Hypothesis Based on Weighted Gene Co-Expression Network Analysis

Identification of Common and Distinct Pathways in Inflammatory Bowel Disease and Colorectal Cancer: A Hypothesis Based on Weighted Gene Co-Expression Network Analysis

Patients with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, are at higher risk to develop colorectal cancer (CRC). However, the underlying mechanisms of this predisposition remain elusive. We performed in-depth comparative computational analyses to gain new insi...

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Bibliographic Details
Main Authors: Afshin Derakhshani, Darya Javadrashid, Nima Hemmat, Antoine Dufour, Antonio Giovanni Solimando, Mahdi Abdoli Shadbad, Pascal H. G. Duijf, Oronzo Brunetti, Nicola Silvestris, Behzad Baradaran
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Genetics
Subjects:
colorectal cancer
inflammatory bowel disease
pathogenesis
systems biology
WGCNA
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.848646/full

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