Effect of aging on the cerebral metabolic mechanism of electroacupuncture treatment in rats with traumatic brain injury
ObjectiveAging has great influence on the clinical treatment effect of cerebrovascular diseases, and evidence suggests that the effect may be associated with age-related brain plasticity. Electroacupuncture is an effective alternative treatment for traumatic brain injury (TBI). In the present study,...
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1081515/full |
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| author | Bei-Bei Huo Mou-Xiong Zheng Mou-Xiong Zheng Xu-Yun Hua Xu-Yun Hua Jia-Jia Wu Xiang-Xin Xing Jie Ma Min Fang Jian-Guang Xu Jian-Guang Xu |
| author_facet | Bei-Bei Huo Mou-Xiong Zheng Mou-Xiong Zheng Xu-Yun Hua Xu-Yun Hua Jia-Jia Wu Xiang-Xin Xing Jie Ma Min Fang Jian-Guang Xu Jian-Guang Xu |
| author_sort | Bei-Bei Huo |
| collection | DOAJ |
| description | ObjectiveAging has great influence on the clinical treatment effect of cerebrovascular diseases, and evidence suggests that the effect may be associated with age-related brain plasticity. Electroacupuncture is an effective alternative treatment for traumatic brain injury (TBI). In the present study, we aimed to explore the effect of aging on the cerebral metabolic mechanism of electroacupuncture to provide new evidence for developing age-specific rehabilitation strategies.MethodsBoth aged (18 months) and young (8 weeks) rats with TBI were analyzed. Thirty-two aged rats were randomly divided into four groups: aged model, aged electroacupuncture, aged sham electroacupuncture, and aged control group. Similarly, 32 young rats were also divided into four groups: young model, young electroacupuncture, young sham electroacupuncture, and young control group. Electroacupuncture was applied to “Bai hui” (GV20) and “Qu chi” (LI11) for 8 weeks. CatWalk gait analysis was then performed at 3 days pre- and post-TBI, and at 1, 2, 4, and 8 weeks after intervention to observe motor function recovery. Positron emission computed tomography (PET/CT) was performed at 3 days pre- and post-TBI, and at 2, 4, and 8 weeks after intervention to detect cerebral metabolism.ResultsGait analysis showed that electroacupuncture improved the forepaw mean intensity in aged rats after 8 weeks of intervention, but after 4 weeks of intervention in young rats. PET/CT revealed increased metabolism in the left (the injured ipsilateral hemisphere) sensorimotor brain areas of aged rats during the electroacupuncture intervention, and increased metabolism in the right (contralateral to injury hemisphere) sensorimotor brain areas of young rats.ResultsThis study demonstrated that aged rats required a longer electroacupuncture intervention duration to improve motor function than that of young rats. The influence of aging on the cerebral metabolism of electroacupuncture treatment was mainly focused on a particular hemisphere. |
| first_indexed | 2024-04-09T18:42:21Z |
| format | Article |
| id | doaj.art-e967d7b5d3ae4aefa26294f047acf40a |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-09T18:42:21Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-e967d7b5d3ae4aefa26294f047acf40a2023-04-11T04:36:13ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-04-011710.3389/fnins.2023.10815151081515Effect of aging on the cerebral metabolic mechanism of electroacupuncture treatment in rats with traumatic brain injuryBei-Bei Huo0Mou-Xiong Zheng1Mou-Xiong Zheng2Xu-Yun Hua3Xu-Yun Hua4Jia-Jia Wu5Xiang-Xin Xing6Jie Ma7Min Fang8Jian-Guang Xu9Jian-Guang Xu10School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaEngineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, ChinaDepartment of Traumatology and Orthopedics, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaEngineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, ChinaDepartment of Traumatology and Orthopedics, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaEngineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, ChinaObjectiveAging has great influence on the clinical treatment effect of cerebrovascular diseases, and evidence suggests that the effect may be associated with age-related brain plasticity. Electroacupuncture is an effective alternative treatment for traumatic brain injury (TBI). In the present study, we aimed to explore the effect of aging on the cerebral metabolic mechanism of electroacupuncture to provide new evidence for developing age-specific rehabilitation strategies.MethodsBoth aged (18 months) and young (8 weeks) rats with TBI were analyzed. Thirty-two aged rats were randomly divided into four groups: aged model, aged electroacupuncture, aged sham electroacupuncture, and aged control group. Similarly, 32 young rats were also divided into four groups: young model, young electroacupuncture, young sham electroacupuncture, and young control group. Electroacupuncture was applied to “Bai hui” (GV20) and “Qu chi” (LI11) for 8 weeks. CatWalk gait analysis was then performed at 3 days pre- and post-TBI, and at 1, 2, 4, and 8 weeks after intervention to observe motor function recovery. Positron emission computed tomography (PET/CT) was performed at 3 days pre- and post-TBI, and at 2, 4, and 8 weeks after intervention to detect cerebral metabolism.ResultsGait analysis showed that electroacupuncture improved the forepaw mean intensity in aged rats after 8 weeks of intervention, but after 4 weeks of intervention in young rats. PET/CT revealed increased metabolism in the left (the injured ipsilateral hemisphere) sensorimotor brain areas of aged rats during the electroacupuncture intervention, and increased metabolism in the right (contralateral to injury hemisphere) sensorimotor brain areas of young rats.ResultsThis study demonstrated that aged rats required a longer electroacupuncture intervention duration to improve motor function than that of young rats. The influence of aging on the cerebral metabolism of electroacupuncture treatment was mainly focused on a particular hemisphere.https://www.frontiersin.org/articles/10.3389/fnins.2023.1081515/fullmetabolic mechanismtraumatic brain injury (TBI)agingsmall animal 18F-FDG PET/CTelectroacupuncturebrain plasticity |
| spellingShingle | Bei-Bei Huo Mou-Xiong Zheng Mou-Xiong Zheng Xu-Yun Hua Xu-Yun Hua Jia-Jia Wu Xiang-Xin Xing Jie Ma Min Fang Jian-Guang Xu Jian-Guang Xu Effect of aging on the cerebral metabolic mechanism of electroacupuncture treatment in rats with traumatic brain injury Frontiers in Neuroscience metabolic mechanism traumatic brain injury (TBI) aging small animal 18F-FDG PET/CT electroacupuncture brain plasticity |
| title | Effect of aging on the cerebral metabolic mechanism of electroacupuncture treatment in rats with traumatic brain injury |
| title_full | Effect of aging on the cerebral metabolic mechanism of electroacupuncture treatment in rats with traumatic brain injury |
| title_fullStr | Effect of aging on the cerebral metabolic mechanism of electroacupuncture treatment in rats with traumatic brain injury |
| title_full_unstemmed | Effect of aging on the cerebral metabolic mechanism of electroacupuncture treatment in rats with traumatic brain injury |
| title_short | Effect of aging on the cerebral metabolic mechanism of electroacupuncture treatment in rats with traumatic brain injury |
| title_sort | effect of aging on the cerebral metabolic mechanism of electroacupuncture treatment in rats with traumatic brain injury |
| topic | metabolic mechanism traumatic brain injury (TBI) aging small animal 18F-FDG PET/CT electroacupuncture brain plasticity |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1081515/full |
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