Alu and b1 repeats have been selectively retained in the upstream and intronic regions of genes of specific functional classes.
Alu and B1 repeats are mobile elements that originated in an initial duplication of the 7SL RNA gene prior to the primate-rodent split about 80 million years ago and currently account for a substantial fraction of the human and mouse genome, respectively. Following the primate-rodent split, Alu and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-12-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC2784220?pdf=render |
| _version_ | 1818034609337663488 |
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| author | Aristotelis Tsirigos Isidore Rigoutsos |
| author_facet | Aristotelis Tsirigos Isidore Rigoutsos |
| author_sort | Aristotelis Tsirigos |
| collection | DOAJ |
| description | Alu and B1 repeats are mobile elements that originated in an initial duplication of the 7SL RNA gene prior to the primate-rodent split about 80 million years ago and currently account for a substantial fraction of the human and mouse genome, respectively. Following the primate-rodent split, Alu and B1 elements spread independently in each of the two genomes in a seemingly random manner, and, according to the prevailing hypothesis, negative selection shaped their final distribution in each genome by forcing the selective loss of certain Alu and B1 copies. In this paper, contrary to the prevailing hypothesis, we present evidence that Alu and B1 elements have been selectively retained in the upstream and intronic regions of genes belonging to specific functional classes. At the same time, we found no evidence for selective loss of these elements in any functional class. A subset of the functional links we discovered corresponds to functions where Alu involvement has actually been experimentally validated, whereas the majority of the functional links we report are novel. Finally, the unexpected finding that Alu and B1 elements show similar biases in their distribution across functional classes, despite having spread independently in their respective genomes, further supports our claim that the extant instances of Alu and B1 elements are the result of positive selection. |
| first_indexed | 2024-12-10T06:41:53Z |
| format | Article |
| id | doaj.art-e9684995d8f249f89a56600b1393b040 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-10T06:41:53Z |
| publishDate | 2009-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-e9684995d8f249f89a56600b1393b0402022-12-22T01:58:46ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582009-12-01512e100061010.1371/journal.pcbi.1000610Alu and b1 repeats have been selectively retained in the upstream and intronic regions of genes of specific functional classes.Aristotelis TsirigosIsidore RigoutsosAlu and B1 repeats are mobile elements that originated in an initial duplication of the 7SL RNA gene prior to the primate-rodent split about 80 million years ago and currently account for a substantial fraction of the human and mouse genome, respectively. Following the primate-rodent split, Alu and B1 elements spread independently in each of the two genomes in a seemingly random manner, and, according to the prevailing hypothesis, negative selection shaped their final distribution in each genome by forcing the selective loss of certain Alu and B1 copies. In this paper, contrary to the prevailing hypothesis, we present evidence that Alu and B1 elements have been selectively retained in the upstream and intronic regions of genes belonging to specific functional classes. At the same time, we found no evidence for selective loss of these elements in any functional class. A subset of the functional links we discovered corresponds to functions where Alu involvement has actually been experimentally validated, whereas the majority of the functional links we report are novel. Finally, the unexpected finding that Alu and B1 elements show similar biases in their distribution across functional classes, despite having spread independently in their respective genomes, further supports our claim that the extant instances of Alu and B1 elements are the result of positive selection.http://europepmc.org/articles/PMC2784220?pdf=render |
| spellingShingle | Aristotelis Tsirigos Isidore Rigoutsos Alu and b1 repeats have been selectively retained in the upstream and intronic regions of genes of specific functional classes. PLoS Computational Biology |
| title | Alu and b1 repeats have been selectively retained in the upstream and intronic regions of genes of specific functional classes. |
| title_full | Alu and b1 repeats have been selectively retained in the upstream and intronic regions of genes of specific functional classes. |
| title_fullStr | Alu and b1 repeats have been selectively retained in the upstream and intronic regions of genes of specific functional classes. |
| title_full_unstemmed | Alu and b1 repeats have been selectively retained in the upstream and intronic regions of genes of specific functional classes. |
| title_short | Alu and b1 repeats have been selectively retained in the upstream and intronic regions of genes of specific functional classes. |
| title_sort | alu and b1 repeats have been selectively retained in the upstream and intronic regions of genes of specific functional classes |
| url | http://europepmc.org/articles/PMC2784220?pdf=render |
| work_keys_str_mv | AT aristotelistsirigos aluandb1repeatshavebeenselectivelyretainedintheupstreamandintronicregionsofgenesofspecificfunctionalclasses AT isidorerigoutsos aluandb1repeatshavebeenselectivelyretainedintheupstreamandintronicregionsofgenesofspecificfunctionalclasses |