Fluorine substituted hydroxyapatite microspheres: Template-free hydrothermal synthesis and sustained fluoride-releasing properties
To avoid sudden release of fluoride, F-substituted hydroxyapatite (FHA) porous microspheres were prepared for the treatment of F-deficiency tissues. In the absence of any template-directing reagents, FHA microspheres with diameters of about 30 μm were successfully fabricated via hydrothermal method...
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| Format: | Article |
| Language: | English |
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University of Novi Sad
2023-09-01
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| Series: | Processing and Application of Ceramics |
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| Online Access: | https://doiserbia.nb.rs/img/doi/1820-6131/2023/1820-61312303248Z.pdf |
| _version_ | 1797641448019984384 |
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| author | Zhu Qing-Xia Li Liu Xu Wan-Ting Nie Quan-Yi Xu Yun-Long Liu Jia-Xin |
| author_facet | Zhu Qing-Xia Li Liu Xu Wan-Ting Nie Quan-Yi Xu Yun-Long Liu Jia-Xin |
| author_sort | Zhu Qing-Xia |
| collection | DOAJ |
| description | To avoid sudden release of fluoride, F-substituted hydroxyapatite (FHA) porous microspheres were prepared for the treatment of F-deficiency tissues. In the absence of any template-directing reagents, FHA microspheres with diameters of about 30 μm were successfully fabricated via hydrothermal method with urea as homogeneous precipitant to regulate the nucleation, growth and self-assembly process. Urea concentration and hydrothermal temperature played an important role in the formation and regulation of spherical hydroxyapatite. The synthesized FHA microspheres with large specific surface area, large pore volume and complex porous structure were efficient for the adsorption and long-term stable release of ionic extracts. Concentration of F- ions in physiological salt solution was maintained in the range of the therapeutic window without exceeding the toxic threshold within 30 days. The ionic extracts of FHA porous microspheres promoted the proliferation of human osteoblast-like cells (MG-63). The fabricated FHA microspheres may be a potential candidate as bioactive fluoride-release carriers for the treatment of osteoporosis and bone defects. |
| first_indexed | 2024-03-11T13:45:43Z |
| format | Article |
| id | doaj.art-e96c9e0cdccb4b18beee5759cb04599c |
| institution | Directory Open Access Journal |
| issn | 1820-6131 2406-1034 |
| language | English |
| last_indexed | 2024-03-11T13:45:43Z |
| publishDate | 2023-09-01 |
| publisher | University of Novi Sad |
| record_format | Article |
| series | Processing and Application of Ceramics |
| spelling | doaj.art-e96c9e0cdccb4b18beee5759cb04599c2023-11-02T10:45:50ZengUniversity of Novi SadProcessing and Application of Ceramics1820-61312406-10342023-09-0117324825510.2298/PAC2303248ZFluorine substituted hydroxyapatite microspheres: Template-free hydrothermal synthesis and sustained fluoride-releasing propertiesZhu Qing-Xia0Li Liu1Xu Wan-Ting2Nie Quan-Yi3Xu Yun-Long4Liu Jia-Xin5Tianjin Key Laboratory of Advanced Fibers and Energy Storage, School of Material Science and Engineering, Tiangong University, Tianjin, ChinaTianjin Key Laboratory of Advanced Fibers and Energy Storage, School of Material Science and Engineering, Tiangong University, Tianjin, ChinaNorth China University of Technology, Beijing, ChinaChaozhou Sanhuan Ceramic Co. Ltd, Guangdong, ChinaTianjin Key Laboratory of Advanced Fibers and Energy Storage, School of Material Science and Engineering, Tiangong University, Tianjin, ChinaTianjin Key Laboratory of Advanced Fibers and Energy Storage, School of Material Science and Engineering, Tiangong University, Tianjin, ChinaTo avoid sudden release of fluoride, F-substituted hydroxyapatite (FHA) porous microspheres were prepared for the treatment of F-deficiency tissues. In the absence of any template-directing reagents, FHA microspheres with diameters of about 30 μm were successfully fabricated via hydrothermal method with urea as homogeneous precipitant to regulate the nucleation, growth and self-assembly process. Urea concentration and hydrothermal temperature played an important role in the formation and regulation of spherical hydroxyapatite. The synthesized FHA microspheres with large specific surface area, large pore volume and complex porous structure were efficient for the adsorption and long-term stable release of ionic extracts. Concentration of F- ions in physiological salt solution was maintained in the range of the therapeutic window without exceeding the toxic threshold within 30 days. The ionic extracts of FHA porous microspheres promoted the proliferation of human osteoblast-like cells (MG-63). The fabricated FHA microspheres may be a potential candidate as bioactive fluoride-release carriers for the treatment of osteoporosis and bone defects.https://doiserbia.nb.rs/img/doi/1820-6131/2023/1820-61312303248Z.pdfporous hydroxyapatitemicrosphereshydrothermal methodself-assemblyfluoride-releasing |
| spellingShingle | Zhu Qing-Xia Li Liu Xu Wan-Ting Nie Quan-Yi Xu Yun-Long Liu Jia-Xin Fluorine substituted hydroxyapatite microspheres: Template-free hydrothermal synthesis and sustained fluoride-releasing properties Processing and Application of Ceramics porous hydroxyapatite microspheres hydrothermal method self-assembly fluoride-releasing |
| title | Fluorine substituted hydroxyapatite microspheres: Template-free hydrothermal synthesis and sustained fluoride-releasing properties |
| title_full | Fluorine substituted hydroxyapatite microspheres: Template-free hydrothermal synthesis and sustained fluoride-releasing properties |
| title_fullStr | Fluorine substituted hydroxyapatite microspheres: Template-free hydrothermal synthesis and sustained fluoride-releasing properties |
| title_full_unstemmed | Fluorine substituted hydroxyapatite microspheres: Template-free hydrothermal synthesis and sustained fluoride-releasing properties |
| title_short | Fluorine substituted hydroxyapatite microspheres: Template-free hydrothermal synthesis and sustained fluoride-releasing properties |
| title_sort | fluorine substituted hydroxyapatite microspheres template free hydrothermal synthesis and sustained fluoride releasing properties |
| topic | porous hydroxyapatite microspheres hydrothermal method self-assembly fluoride-releasing |
| url | https://doiserbia.nb.rs/img/doi/1820-6131/2023/1820-61312303248Z.pdf |
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