How Our Microbiome Influences the Pathogenesis of Alopecia Areata
Alopecia areata is a multifactorial autoimmune-based disease with a complex pathogenesis. As in all autoimmune diseases, genetic predisposition is key. The collapse of the immune privilege of the hair follicle leading to scalp loss is a major pathogenic event in alopecia areata. The microbiota consi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/13/10/1860 |
| _version_ | 1797473172194328576 |
|---|---|
| author | Pedro Sánchez-Pellicer Laura Navarro-Moratalla Eva Núñez-Delegido Juan Agüera-Santos Vicente Navarro-López |
| author_facet | Pedro Sánchez-Pellicer Laura Navarro-Moratalla Eva Núñez-Delegido Juan Agüera-Santos Vicente Navarro-López |
| author_sort | Pedro Sánchez-Pellicer |
| collection | DOAJ |
| description | Alopecia areata is a multifactorial autoimmune-based disease with a complex pathogenesis. As in all autoimmune diseases, genetic predisposition is key. The collapse of the immune privilege of the hair follicle leading to scalp loss is a major pathogenic event in alopecia areata. The microbiota considered a bacterial ecosystem located in a specific area of the human body could somehow influence the pathogenesis of alopecia areata, as it occurs in other autoimmune diseases. Moreover, the Next Generation Sequencing of the 16S rRNA bacterial gene and the metagenomic methodology have provided an excellent characterization of the microbiota. The aim of this narrative review is to examine the published literature on the cutaneous and intestinal microbiota in alopecia areata to be able to establish a pathogenic link. In this review, we summarize the influence of the microbiota on the development of alopecia areata. We first introduce the general pathogenic mechanisms that cause alopecia areata to understand the influence that the microbiota may exert and then we summarize the studies that have been carried out on what type of gut and skin microbiota is found in patients with this disease. |
| first_indexed | 2024-03-09T20:11:11Z |
| format | Article |
| id | doaj.art-e96d3304e8ad492395e3c8c4744a498e |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T20:11:11Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-e96d3304e8ad492395e3c8c4744a498e2023-11-24T00:16:21ZengMDPI AGGenes2073-44252022-10-011310186010.3390/genes13101860How Our Microbiome Influences the Pathogenesis of Alopecia AreataPedro Sánchez-Pellicer0Laura Navarro-Moratalla1Eva Núñez-Delegido2Juan Agüera-Santos3Vicente Navarro-López4MiBioPath Research Group, Department of Clinical Medicine, Health Sciences Faculty, Catholic University of Murcia, Campus de los Jerónimos 135, 30107 Murcia, SpainMiBioPath Research Group, Department of Clinical Medicine, Health Sciences Faculty, Catholic University of Murcia, Campus de los Jerónimos 135, 30107 Murcia, SpainMiBioPath Research Group, Department of Clinical Medicine, Health Sciences Faculty, Catholic University of Murcia, Campus de los Jerónimos 135, 30107 Murcia, SpainMiBioPath Research Group, Department of Clinical Medicine, Health Sciences Faculty, Catholic University of Murcia, Campus de los Jerónimos 135, 30107 Murcia, SpainMiBioPath Research Group, Department of Clinical Medicine, Health Sciences Faculty, Catholic University of Murcia, Campus de los Jerónimos 135, 30107 Murcia, SpainAlopecia areata is a multifactorial autoimmune-based disease with a complex pathogenesis. As in all autoimmune diseases, genetic predisposition is key. The collapse of the immune privilege of the hair follicle leading to scalp loss is a major pathogenic event in alopecia areata. The microbiota considered a bacterial ecosystem located in a specific area of the human body could somehow influence the pathogenesis of alopecia areata, as it occurs in other autoimmune diseases. Moreover, the Next Generation Sequencing of the 16S rRNA bacterial gene and the metagenomic methodology have provided an excellent characterization of the microbiota. The aim of this narrative review is to examine the published literature on the cutaneous and intestinal microbiota in alopecia areata to be able to establish a pathogenic link. In this review, we summarize the influence of the microbiota on the development of alopecia areata. We first introduce the general pathogenic mechanisms that cause alopecia areata to understand the influence that the microbiota may exert and then we summarize the studies that have been carried out on what type of gut and skin microbiota is found in patients with this disease.https://www.mdpi.com/2073-4425/13/10/1860alopecia areatanon-scarring alopeciaskin microbiotahair follicle microbiotascalp microbiotagut microbiota |
| spellingShingle | Pedro Sánchez-Pellicer Laura Navarro-Moratalla Eva Núñez-Delegido Juan Agüera-Santos Vicente Navarro-López How Our Microbiome Influences the Pathogenesis of Alopecia Areata Genes alopecia areata non-scarring alopecia skin microbiota hair follicle microbiota scalp microbiota gut microbiota |
| title | How Our Microbiome Influences the Pathogenesis of Alopecia Areata |
| title_full | How Our Microbiome Influences the Pathogenesis of Alopecia Areata |
| title_fullStr | How Our Microbiome Influences the Pathogenesis of Alopecia Areata |
| title_full_unstemmed | How Our Microbiome Influences the Pathogenesis of Alopecia Areata |
| title_short | How Our Microbiome Influences the Pathogenesis of Alopecia Areata |
| title_sort | how our microbiome influences the pathogenesis of alopecia areata |
| topic | alopecia areata non-scarring alopecia skin microbiota hair follicle microbiota scalp microbiota gut microbiota |
| url | https://www.mdpi.com/2073-4425/13/10/1860 |
| work_keys_str_mv | AT pedrosanchezpellicer howourmicrobiomeinfluencesthepathogenesisofalopeciaareata AT lauranavarromoratalla howourmicrobiomeinfluencesthepathogenesisofalopeciaareata AT evanunezdelegido howourmicrobiomeinfluencesthepathogenesisofalopeciaareata AT juanaguerasantos howourmicrobiomeinfluencesthepathogenesisofalopeciaareata AT vicentenavarrolopez howourmicrobiomeinfluencesthepathogenesisofalopeciaareata |