Identification of Activated Cdc42-Associated Kinase Inhibitors as Potential Anticancer Agents Using Pharmacoinformatic Approaches

Identification of Activated Cdc42-Associated Kinase Inhibitors as Potential Anticancer Agents Using Pharmacoinformatic Approaches

Background: Activated Cdc42-associated kinase (ACK1) is essential for numerous cellular functions, such as growth, proliferation, and migration. ACK1 signaling occurs through multiple receptor tyrosine kinases; therefore, its inhibition can provide effective antiproliferative effects against multipl...

Full description

Bibliographic Details
Main Authors: Vikas Kumar, Raj Kumar, Shraddha Parate, Danishuddin, Gihwan Lee, Moonhyuk Kwon, Seong-Hee Jeong, Hyeon-Su Ro, Keun Woo Lee, Seon-Won Kim
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Biomolecules
Subjects:
ACK1
pharmacophore modeling
docking
molecular dynamics simulations
cancer
inhibitor
Online Access:https://www.mdpi.com/2218-273X/13/2/217

Similar Items

Similar Items