NEW 1,3,4-TIADIAZOLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY
The method of obtaining new heterocyclic compounds - chlorides 2-[(Z)-1-(3,5-diaryl-1,3,4-thiadiazol-2(3H)-iliden)methyl]-3,5-diaryl-1,3,4-thiadiazol-3 was developed. The structure and individuality of the obtained compounds are proved by the physico-chemical methods for the identification of organi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
|
| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/585 |
| _version_ | 1797874996065861632 |
|---|---|
| author | A. S. Koshevenko V. N. Yuskovets E. P. Ananyeva I. P. Yakovlev T. L. Semakova |
| author_facet | A. S. Koshevenko V. N. Yuskovets E. P. Ananyeva I. P. Yakovlev T. L. Semakova |
| author_sort | A. S. Koshevenko |
| collection | DOAJ |
| description | The method of obtaining new heterocyclic compounds - chlorides 2-[(Z)-1-(3,5-diaryl-1,3,4-thiadiazol-2(3H)-iliden)methyl]-3,5-diaryl-1,3,4-thiadiazol-3 was developed. The structure and individuality of the obtained compounds are proved by the physico-chemical methods for the identification of organic compounds: 1Н and 13С NMR, IR spectrometry, mass spectrometry. Antibacterial activity was defined against Escherihia coli, Staphylococcus aureus, Bacillus cereus. It was shown that these compounds have a pronounced antibacterial activity against gram-positive bacteria. The most active compound has been identified, which can potentially be used in medicine as an antimicrobial agent. |
| first_indexed | 2024-04-10T01:40:46Z |
| format | Article |
| id | doaj.art-e971c7f3d14e41168d0d308b306bd074 |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2024-04-10T01:40:46Z |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-e971c7f3d14e41168d0d308b306bd0742023-03-13T09:13:59ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-01029698585NEW 1,3,4-TIADIAZOLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITYA. S. Koshevenko0V. N. Yuskovets1E. P. Ananyeva2I. P. Yakovlev3T. L. Semakova4ФГБОУ ВО «Санкт-Петербургский химико-фармацевтический университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России)ФГБОУ ВО «Санкт-Петербургский химико-фармацевтический университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России)ФГБОУ ВО «Санкт-Петербургский химико-фармацевтический университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России)ФГБОУ ВО «Санкт-Петербургский химико-фармацевтический университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России)ФГБОУ ВО «Санкт-Петербургский химико-фармацевтический университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России)The method of obtaining new heterocyclic compounds - chlorides 2-[(Z)-1-(3,5-diaryl-1,3,4-thiadiazol-2(3H)-iliden)methyl]-3,5-diaryl-1,3,4-thiadiazol-3 was developed. The structure and individuality of the obtained compounds are proved by the physico-chemical methods for the identification of organic compounds: 1Н and 13С NMR, IR spectrometry, mass spectrometry. Antibacterial activity was defined against Escherihia coli, Staphylococcus aureus, Bacillus cereus. It was shown that these compounds have a pronounced antibacterial activity against gram-positive bacteria. The most active compound has been identified, which can potentially be used in medicine as an antimicrobial agent.https://www.pharmjournal.ru/jour/article/view/5851,3,4-тиадиазолмалонилдихлоридn’-арилтиобензгидразидантимикробная активностьминимальная подавляющая концентрация |
| spellingShingle | A. S. Koshevenko V. N. Yuskovets E. P. Ananyeva I. P. Yakovlev T. L. Semakova NEW 1,3,4-TIADIAZOLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY Разработка и регистрация лекарственных средств 1,3,4-тиадиазол малонилдихлорид n’-арилтиобензгидразид антимикробная активность минимальная подавляющая концентрация |
| title | NEW 1,3,4-TIADIAZOLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY |
| title_full | NEW 1,3,4-TIADIAZOLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY |
| title_fullStr | NEW 1,3,4-TIADIAZOLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY |
| title_full_unstemmed | NEW 1,3,4-TIADIAZOLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY |
| title_short | NEW 1,3,4-TIADIAZOLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY |
| title_sort | new 1 3 4 tiadiazole derivatives with antibacterial activity |
| topic | 1,3,4-тиадиазол малонилдихлорид n’-арилтиобензгидразид антимикробная активность минимальная подавляющая концентрация |
| url | https://www.pharmjournal.ru/jour/article/view/585 |
| work_keys_str_mv | AT askoshevenko new134tiadiazolederivativeswithantibacterialactivity AT vnyuskovets new134tiadiazolederivativeswithantibacterialactivity AT epananyeva new134tiadiazolederivativeswithantibacterialactivity AT ipyakovlev new134tiadiazolederivativeswithantibacterialactivity AT tlsemakova new134tiadiazolederivativeswithantibacterialactivity |