BLOOD LEVELS OF INTERLEUKIN-6 AND INTERLEUKIN-10 IN SERUM AND BIOMARKERS OF ACUTE KIDNEY INJURY IN ACUTE CORONARY SYNDROME
Certain correlations between changes of cytokine levels and kidney dysfunction, as well as their prognostic significance for development of acute kidney injury (АКI) in different clinical forms of ischemic heart disease (IHD) seem to be worth of further studies. The levels of IL-6 and IL-10 and thei...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2015-03-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/807 |
| _version_ | 1826534231672619008 |
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| author | M. A. Shalenkova Z. D. Mikhailova P. F. Klimkin E. T. Manyukova |
| author_facet | M. A. Shalenkova Z. D. Mikhailova P. F. Klimkin E. T. Manyukova |
| author_sort | M. A. Shalenkova |
| collection | DOAJ |
| description | Certain correlations between changes of cytokine levels and kidney dysfunction, as well as their prognostic significance for development of acute kidney injury (АКI) in different clinical forms of ischemic heart disease (IHD) seem to be worth of further studies. The levels of IL-6 and IL-10 and their correlation with serum creatinine (sCr) and lipocalin levels in urine (u-NGAL) were studied in 98 IHD patients, of them 93 presented with acute coronary syndrome (ACS) and 5, with stable angina pectoris. ACS patients were found to have increased levels of IL-6, IL-10, sCr, u-NGAL. IL-6 and IL-10 contents proved to be increased in cases of non-ST-segment elevation ACS (NSTE-ACS), and during AKI development. According to serum creatinin levels, AKI was more frequently revealed in patients with NSTE-ACS. Urinary NGAL levels were found to be higher in ACS with ST segment elevation. |
| first_indexed | 2024-03-08T05:50:11Z |
| format | Article |
| id | doaj.art-e9749093e88a4d879b383968a1e8441a |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:19:44Z |
| publishDate | 2015-03-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-e9749093e88a4d879b383968a1e8441a2025-03-11T17:59:06ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2015-03-01171475210.15789/1563-0625-2015-1-47-52732BLOOD LEVELS OF INTERLEUKIN-6 AND INTERLEUKIN-10 IN SERUM AND BIOMARKERS OF ACUTE KIDNEY INJURY IN ACUTE CORONARY SYNDROMEM. A. Shalenkova0Z. D. Mikhailova1P. F. Klimkin2E. T. Manyukova3Municipal Clinical Hospital N 38 603000, Russian Federation, N. Novgorod, Chernyshevsky str., 22.Municipal Clinical Hospital N 38 603000, Russian Federation, N. Novgorod, Chernyshevsky str., 22.Municipal Clinical Hospital N 38 603000, Russian Federation, N. Novgorod, Chernyshevsky str., 22.Municipal Clinical Hospital N 38 603000, Russian Federation, N. Novgorod, Chernyshevsky str., 22.Certain correlations between changes of cytokine levels and kidney dysfunction, as well as their prognostic significance for development of acute kidney injury (АКI) in different clinical forms of ischemic heart disease (IHD) seem to be worth of further studies. The levels of IL-6 and IL-10 and their correlation with serum creatinine (sCr) and lipocalin levels in urine (u-NGAL) were studied in 98 IHD patients, of them 93 presented with acute coronary syndrome (ACS) and 5, with stable angina pectoris. ACS patients were found to have increased levels of IL-6, IL-10, sCr, u-NGAL. IL-6 and IL-10 contents proved to be increased in cases of non-ST-segment elevation ACS (NSTE-ACS), and during AKI development. According to serum creatinin levels, AKI was more frequently revealed in patients with NSTE-ACS. Urinary NGAL levels were found to be higher in ACS with ST segment elevation.https://www.mimmun.ru/mimmun/article/view/807interleukinscreatinineneutrophil gelatinase-associated lipocalin (ngal)acute coronary syndromeacute kidney injury |
| spellingShingle | M. A. Shalenkova Z. D. Mikhailova P. F. Klimkin E. T. Manyukova BLOOD LEVELS OF INTERLEUKIN-6 AND INTERLEUKIN-10 IN SERUM AND BIOMARKERS OF ACUTE KIDNEY INJURY IN ACUTE CORONARY SYNDROME Медицинская иммунология interleukins creatinine neutrophil gelatinase-associated lipocalin (ngal) acute coronary syndrome acute kidney injury |
| title | BLOOD LEVELS OF INTERLEUKIN-6 AND INTERLEUKIN-10 IN SERUM AND BIOMARKERS OF ACUTE KIDNEY INJURY IN ACUTE CORONARY SYNDROME |
| title_full | BLOOD LEVELS OF INTERLEUKIN-6 AND INTERLEUKIN-10 IN SERUM AND BIOMARKERS OF ACUTE KIDNEY INJURY IN ACUTE CORONARY SYNDROME |
| title_fullStr | BLOOD LEVELS OF INTERLEUKIN-6 AND INTERLEUKIN-10 IN SERUM AND BIOMARKERS OF ACUTE KIDNEY INJURY IN ACUTE CORONARY SYNDROME |
| title_full_unstemmed | BLOOD LEVELS OF INTERLEUKIN-6 AND INTERLEUKIN-10 IN SERUM AND BIOMARKERS OF ACUTE KIDNEY INJURY IN ACUTE CORONARY SYNDROME |
| title_short | BLOOD LEVELS OF INTERLEUKIN-6 AND INTERLEUKIN-10 IN SERUM AND BIOMARKERS OF ACUTE KIDNEY INJURY IN ACUTE CORONARY SYNDROME |
| title_sort | blood levels of interleukin 6 and interleukin 10 in serum and biomarkers of acute kidney injury in acute coronary syndrome |
| topic | interleukins creatinine neutrophil gelatinase-associated lipocalin (ngal) acute coronary syndrome acute kidney injury |
| url | https://www.mimmun.ru/mimmun/article/view/807 |
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