Carboxy-terminal mutations of bile acid CoA:N-acyltransferase alter activity and substrate specificity

Carboxy-terminal mutations of bile acid CoA:N-acyltransferase alter activity and substrate specificity

Bile acid CoA:amino acid N-acyltransferase (BAAT) is the terminal enzyme in the synthesis of bile salts from cholesterol and catalyzes the conjugation of taurine or glycine to bile acid CoA thioesters to form bile acid N-acylamidates. BAAT has a dual localization to the cytosol and peroxisomes, poss...

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Bibliographic Details
Main Authors: Nathan A. Styles, Erin M. Shonsey, Josie L. Falany, Amber L. Guidry, Stephen Barnes, Charles N. Falany
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Journal of Lipid Research
Subjects:
bile acid conjugation
bile acid amidation
taurine
glycine
N-acyltransferase
bile acid ligase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520351518

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