Is glucose pattern of OGTT associated with late-onset gestational diabetes and adverse pregnant outcomes?
AbstractBackground The heterogeneity of oral glucose tolerance test (OGTT) patterns during pregnancy remains unclear. This study aims to identify latent OGTT patterns in pregnant women and investigate the high-risk population for late-onset gestational diabetes mellitus (GDM).Methods This study incl...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2024.2302516 |
| _version_ | 1797302177331412992 |
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| author | Enjie Zhang Shaofei Su Shen Gao Yue Zhang Jianhui Liu Shuanghua Xie Wentao Yue Ruixia Liu Chenghong Yin |
| author_facet | Enjie Zhang Shaofei Su Shen Gao Yue Zhang Jianhui Liu Shuanghua Xie Wentao Yue Ruixia Liu Chenghong Yin |
| author_sort | Enjie Zhang |
| collection | DOAJ |
| description | AbstractBackground The heterogeneity of oral glucose tolerance test (OGTT) patterns during pregnancy remains unclear. This study aims to identify latent OGTT patterns in pregnant women and investigate the high-risk population for late-onset gestational diabetes mellitus (GDM).Methods This study including 17,723 participants was conducted from 2018 to 2021. Latent mixture modeling was used to identify subgroups. Modified Poisson regression was performed to explore the relationship between OGTT patterns and late-onset GDM or adverse perinatal outcomes.Results Three distinct glucose patterns, high, medium, and low glucose levels (HG, MG, and LG patterns) were identified. The HG pattern represented 28.5% of the participants and 5.5% of them developed late-onset GDM. A five-fold higher risk of late-onset GDM was found in HG pattern than in LG pattern (relative risk [RR]: 5.17, 95% confidence interval [CI]: 3.38-7.92) after adjustment. Participants in HG pattern were more likely to have macrosomia, large for gestational age, preterm birth, and cesarean deliveries, with RRs of 1.59 (1.31-1.93), 1.55 (1.33-1.82), 1.30 (1.02-1.64) and 1.15 (1.08-1.23), respectively.Conclusion Three distinct OGTT patterns presented different risks of late-onset GDM and adverse perinatal outcomes, indicating that timely monitoring of glucose levels after OGTT should be performed in pregnant women with HG pattern. |
| first_indexed | 2024-03-07T23:33:03Z |
| format | Article |
| id | doaj.art-e9782334cab44da9ae62541cd15238f7 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-07T23:33:03Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-e9782334cab44da9ae62541cd15238f72024-02-20T11:58:24ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155210.1080/07853890.2024.2302516Is glucose pattern of OGTT associated with late-onset gestational diabetes and adverse pregnant outcomes?Enjie Zhang0Shaofei Su1Shen Gao2Yue Zhang3Jianhui Liu4Shuanghua Xie5Wentao Yue6Ruixia Liu7Chenghong Yin8Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaAbstractBackground The heterogeneity of oral glucose tolerance test (OGTT) patterns during pregnancy remains unclear. This study aims to identify latent OGTT patterns in pregnant women and investigate the high-risk population for late-onset gestational diabetes mellitus (GDM).Methods This study including 17,723 participants was conducted from 2018 to 2021. Latent mixture modeling was used to identify subgroups. Modified Poisson regression was performed to explore the relationship between OGTT patterns and late-onset GDM or adverse perinatal outcomes.Results Three distinct glucose patterns, high, medium, and low glucose levels (HG, MG, and LG patterns) were identified. The HG pattern represented 28.5% of the participants and 5.5% of them developed late-onset GDM. A five-fold higher risk of late-onset GDM was found in HG pattern than in LG pattern (relative risk [RR]: 5.17, 95% confidence interval [CI]: 3.38-7.92) after adjustment. Participants in HG pattern were more likely to have macrosomia, large for gestational age, preterm birth, and cesarean deliveries, with RRs of 1.59 (1.31-1.93), 1.55 (1.33-1.82), 1.30 (1.02-1.64) and 1.15 (1.08-1.23), respectively.Conclusion Three distinct OGTT patterns presented different risks of late-onset GDM and adverse perinatal outcomes, indicating that timely monitoring of glucose levels after OGTT should be performed in pregnant women with HG pattern.https://www.tandfonline.com/doi/10.1080/07853890.2024.2302516Gestational diabetes mellituslate-onsetoral glucose tolerance testpatternpregnancy outcomeslatent mixture modeling |
| spellingShingle | Enjie Zhang Shaofei Su Shen Gao Yue Zhang Jianhui Liu Shuanghua Xie Wentao Yue Ruixia Liu Chenghong Yin Is glucose pattern of OGTT associated with late-onset gestational diabetes and adverse pregnant outcomes? Annals of Medicine Gestational diabetes mellitus late-onset oral glucose tolerance test pattern pregnancy outcomes latent mixture modeling |
| title | Is glucose pattern of OGTT associated with late-onset gestational diabetes and adverse pregnant outcomes? |
| title_full | Is glucose pattern of OGTT associated with late-onset gestational diabetes and adverse pregnant outcomes? |
| title_fullStr | Is glucose pattern of OGTT associated with late-onset gestational diabetes and adverse pregnant outcomes? |
| title_full_unstemmed | Is glucose pattern of OGTT associated with late-onset gestational diabetes and adverse pregnant outcomes? |
| title_short | Is glucose pattern of OGTT associated with late-onset gestational diabetes and adverse pregnant outcomes? |
| title_sort | is glucose pattern of ogtt associated with late onset gestational diabetes and adverse pregnant outcomes |
| topic | Gestational diabetes mellitus late-onset oral glucose tolerance test pattern pregnancy outcomes latent mixture modeling |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2024.2302516 |
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