Suicidality in civilian women with PTSD: Possible link to childhood maltreatment, proinflammatory molecules, and their genetic variations
Background: Posttraumatic stress disorder (PTSD) is a robust risk factor for suicide. Studies have suggested an association between suicide and elevated inflammatory markers, although such evidence in PTSD is scarce. Suicide risk, PTSD, and inflammatory molecules are all shown to be associated with...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
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Elsevier
2023-07-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354623000649 |
| _version_ | 1797797973303754752 |
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| author | Hitomi Kawanishi Hiroaki Hori Fuyuko Yoshida Mariko Itoh Mingming Lin Madoka Niwa Megumi Narita Takeshi Otsuka Keiko Ino Risa Imai Shin Fukudo Toshiko Kamo Hiroshi Kunugi Yoshiharu Kim |
| author_facet | Hitomi Kawanishi Hiroaki Hori Fuyuko Yoshida Mariko Itoh Mingming Lin Madoka Niwa Megumi Narita Takeshi Otsuka Keiko Ino Risa Imai Shin Fukudo Toshiko Kamo Hiroshi Kunugi Yoshiharu Kim |
| author_sort | Hitomi Kawanishi |
| collection | DOAJ |
| description | Background: Posttraumatic stress disorder (PTSD) is a robust risk factor for suicide. Studies have suggested an association between suicide and elevated inflammatory markers, although such evidence in PTSD is scarce. Suicide risk, PTSD, and inflammatory molecules are all shown to be associated with childhood maltreatment and genetic factors. Methods: We examined the association between suicidal ideation/risk and inflammatory markers in 83 civilian women with PTSD, and explored the possible influence of childhood maltreatment and inflammatory genes. Suicidal ideation and risk were assessed using the Beck Depression Inventory-II and the Mini-International Neuropsychiatric Interview. Childhood maltreatment history was assessed with the Childhood Trauma Questionnaire (CTQ). Blood levels of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6) and high-sensitivity tumor necrosis factor-α were measured. Genetic polymorphisms of CRP rs2794520 and IL6 rs1800796 were genotyped. Results: Suicidal ideation was significantly positively correlated with hsCRP (p = 0.002) and IL-6 (p = 0.015) levels. Suicide risk weighted score was significantly positively correlated with hsCRP (p = 0.016) levels. The risk alleles of CRP rs2794520 and IL6 rs1800796 leading to increased respective protein levels were dose-dependently associated with higher risk of suicide (p = 0.007 and p = 0.029, respectively). The CTQ total score was significantly correlated with suicidal ideation and risk, but not with inflammatory marker levels. Furthermore, a multivariate regression analysis controlling for PTSD severity and potential confounders revealed that rs2794520 and rs1800796, but not hsCRP or IL-6 levels, significantly predicted suicidal ideation (p < 0.001) and risk (p = 0.007), respectively. Conclusion: Genetic variations within inflammatory genes might be useful in detecting PTSD patients at high risk of suicide. |
| first_indexed | 2024-03-13T03:56:26Z |
| format | Article |
| id | doaj.art-e9797d4cdff545c28b34b4e6262d3a43 |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-03-13T03:56:26Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-e9797d4cdff545c28b34b4e6262d3a432023-06-22T05:05:27ZengElsevierBrain, Behavior, & Immunity - Health2666-35462023-07-0130100650Suicidality in civilian women with PTSD: Possible link to childhood maltreatment, proinflammatory molecules, and their genetic variationsHitomi Kawanishi0Hiroaki Hori1Fuyuko Yoshida2Mariko Itoh3Mingming Lin4Madoka Niwa5Megumi Narita6Takeshi Otsuka7Keiko Ino8Risa Imai9Shin Fukudo10Toshiko Kamo11Hiroshi Kunugi12Yoshiharu Kim13Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan; Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; Corresponding author. Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan; Corresponding author. Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan; Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, JapanDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan; Center for Environmental and Health Sciences, Hokkaido University, Hokkaido, JapanDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan; Laboratory for Imagination and Executive Functions, RIKEN Center for Brain Science, Wako, Saitama, JapanDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, JapanDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, JapanDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, JapanDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan; Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; Risa Irinaka Mental Clinic, Nagoya, JapanDepartment of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanWakamatsu-cho Mental and Skin Clinic, Tokyo, JapanDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan; Department of Psychiatry, Teikyo University School of Medicine, Tokyo, JapanDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, JapanBackground: Posttraumatic stress disorder (PTSD) is a robust risk factor for suicide. Studies have suggested an association between suicide and elevated inflammatory markers, although such evidence in PTSD is scarce. Suicide risk, PTSD, and inflammatory molecules are all shown to be associated with childhood maltreatment and genetic factors. Methods: We examined the association between suicidal ideation/risk and inflammatory markers in 83 civilian women with PTSD, and explored the possible influence of childhood maltreatment and inflammatory genes. Suicidal ideation and risk were assessed using the Beck Depression Inventory-II and the Mini-International Neuropsychiatric Interview. Childhood maltreatment history was assessed with the Childhood Trauma Questionnaire (CTQ). Blood levels of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6) and high-sensitivity tumor necrosis factor-α were measured. Genetic polymorphisms of CRP rs2794520 and IL6 rs1800796 were genotyped. Results: Suicidal ideation was significantly positively correlated with hsCRP (p = 0.002) and IL-6 (p = 0.015) levels. Suicide risk weighted score was significantly positively correlated with hsCRP (p = 0.016) levels. The risk alleles of CRP rs2794520 and IL6 rs1800796 leading to increased respective protein levels were dose-dependently associated with higher risk of suicide (p = 0.007 and p = 0.029, respectively). The CTQ total score was significantly correlated with suicidal ideation and risk, but not with inflammatory marker levels. Furthermore, a multivariate regression analysis controlling for PTSD severity and potential confounders revealed that rs2794520 and rs1800796, but not hsCRP or IL-6 levels, significantly predicted suicidal ideation (p < 0.001) and risk (p = 0.007), respectively. Conclusion: Genetic variations within inflammatory genes might be useful in detecting PTSD patients at high risk of suicide.http://www.sciencedirect.com/science/article/pii/S2666354623000649PTSDSuicideInflammationGenetic variationChildhood maltreatment |
| spellingShingle | Hitomi Kawanishi Hiroaki Hori Fuyuko Yoshida Mariko Itoh Mingming Lin Madoka Niwa Megumi Narita Takeshi Otsuka Keiko Ino Risa Imai Shin Fukudo Toshiko Kamo Hiroshi Kunugi Yoshiharu Kim Suicidality in civilian women with PTSD: Possible link to childhood maltreatment, proinflammatory molecules, and their genetic variations Brain, Behavior, & Immunity - Health PTSD Suicide Inflammation Genetic variation Childhood maltreatment |
| title | Suicidality in civilian women with PTSD: Possible link to childhood maltreatment, proinflammatory molecules, and their genetic variations |
| title_full | Suicidality in civilian women with PTSD: Possible link to childhood maltreatment, proinflammatory molecules, and their genetic variations |
| title_fullStr | Suicidality in civilian women with PTSD: Possible link to childhood maltreatment, proinflammatory molecules, and their genetic variations |
| title_full_unstemmed | Suicidality in civilian women with PTSD: Possible link to childhood maltreatment, proinflammatory molecules, and their genetic variations |
| title_short | Suicidality in civilian women with PTSD: Possible link to childhood maltreatment, proinflammatory molecules, and their genetic variations |
| title_sort | suicidality in civilian women with ptsd possible link to childhood maltreatment proinflammatory molecules and their genetic variations |
| topic | PTSD Suicide Inflammation Genetic variation Childhood maltreatment |
| url | http://www.sciencedirect.com/science/article/pii/S2666354623000649 |
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