Towards synthetic molecular motors: a model elastic-network study
Protein molecular motors play a fundamental role in biological cells and development of their synthetic counterparts is a major challenge. Here, we show how a model motor system with the operation mechanism resembling that of muscle myosin can be designed at the concept level, without addressing the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
IOP Publishing
2016-01-01
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| Series: | New Journal of Physics |
| Online Access: | https://doi.org/10.1088/1367-2630/18/4/043006 |
| _version_ | 1797750998022750208 |
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| author | Amartya Sarkar Holger Flechsig Alexander S Mikhailov |
| author_facet | Amartya Sarkar Holger Flechsig Alexander S Mikhailov |
| author_sort | Amartya Sarkar |
| collection | DOAJ |
| description | Protein molecular motors play a fundamental role in biological cells and development of their synthetic counterparts is a major challenge. Here, we show how a model motor system with the operation mechanism resembling that of muscle myosin can be designed at the concept level, without addressing the implementation aspects. The model is constructed as an elastic network, similar to the coarse-grained descriptions used for real proteins. We show by numerical simulations that the designed synthetic motor can operate as a deterministic or Brownian ratchet and that there is a continuous transition between such two regimes. The motor operation under external load, approaching the stall condition, is also analysed. |
| first_indexed | 2024-03-12T16:41:59Z |
| format | Article |
| id | doaj.art-e97c717fe1c740b6ae7a87bfea33db55 |
| institution | Directory Open Access Journal |
| issn | 1367-2630 |
| language | English |
| last_indexed | 2024-03-12T16:41:59Z |
| publishDate | 2016-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | New Journal of Physics |
| spelling | doaj.art-e97c717fe1c740b6ae7a87bfea33db552023-08-08T14:30:00ZengIOP PublishingNew Journal of Physics1367-26302016-01-0118404300610.1088/1367-2630/18/4/043006Towards synthetic molecular motors: a model elastic-network studyAmartya Sarkar0Holger Flechsig1Alexander S Mikhailov2Department of Physical Chemistry, Fritz Haber Institute of the Max Planck Society , Faradayweg 4-6, D-14195 Berlin, GermanyDepartment of Physical Chemistry, Fritz Haber Institute of the Max Planck Society , Faradayweg 4-6, D-14195 Berlin, Germany; Research Center for the Mathematics on Chromatin Live Dynamics (RcMcD) and Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University , 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, JapanDepartment of Physical Chemistry, Fritz Haber Institute of the Max Planck Society , Faradayweg 4-6, D-14195 Berlin, Germany; Research Center for the Mathematics on Chromatin Live Dynamics (RcMcD) and Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University , 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, JapanProtein molecular motors play a fundamental role in biological cells and development of their synthetic counterparts is a major challenge. Here, we show how a model motor system with the operation mechanism resembling that of muscle myosin can be designed at the concept level, without addressing the implementation aspects. The model is constructed as an elastic network, similar to the coarse-grained descriptions used for real proteins. We show by numerical simulations that the designed synthetic motor can operate as a deterministic or Brownian ratchet and that there is a continuous transition between such two regimes. The motor operation under external load, approaching the stall condition, is also analysed.https://doi.org/10.1088/1367-2630/18/4/043006 |
| spellingShingle | Amartya Sarkar Holger Flechsig Alexander S Mikhailov Towards synthetic molecular motors: a model elastic-network study New Journal of Physics |
| title | Towards synthetic molecular motors: a model elastic-network study |
| title_full | Towards synthetic molecular motors: a model elastic-network study |
| title_fullStr | Towards synthetic molecular motors: a model elastic-network study |
| title_full_unstemmed | Towards synthetic molecular motors: a model elastic-network study |
| title_short | Towards synthetic molecular motors: a model elastic-network study |
| title_sort | towards synthetic molecular motors a model elastic network study |
| url | https://doi.org/10.1088/1367-2630/18/4/043006 |
| work_keys_str_mv | AT amartyasarkar towardssyntheticmolecularmotorsamodelelasticnetworkstudy AT holgerflechsig towardssyntheticmolecularmotorsamodelelasticnetworkstudy AT alexandersmikhailov towardssyntheticmolecularmotorsamodelelasticnetworkstudy |