Effects of Whey Protein Isolate on Body Composition, Muscle Mass, and Strength of Chronic Heart Failure Patients: A Randomized Clinical Trial
Heart failure (HF) is associated with a reduction of skeletal muscle mass. Whey protein isolate (WPI) has been beneficial in increasing muscle mass and strength, in addition to improving body composition. The goal of this research was to evaluate the effect of WPI on the body composition, muscle mas...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/10/2320 |
| _version_ | 1797598802510610432 |
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| author | Elisa M. dos Santos Annie S. B. Moreira Grazielle V. B. Huguenin Eduardo Tibiriça Andrea De Lorenzo |
| author_facet | Elisa M. dos Santos Annie S. B. Moreira Grazielle V. B. Huguenin Eduardo Tibiriça Andrea De Lorenzo |
| author_sort | Elisa M. dos Santos |
| collection | DOAJ |
| description | Heart failure (HF) is associated with a reduction of skeletal muscle mass. Whey protein isolate (WPI) has been beneficial in increasing muscle mass and strength, in addition to improving body composition. The goal of this research was to evaluate the effect of WPI on the body composition, muscle mass, and strength of chronic HF patients. For this purpose, twenty-five patients of both genders with predominantly NYHA I functional class and a median age of 65.5 (60.5–71.0) years were used to conduct a randomized, single-blind, placebo-controlled clinical trial and received 30 g per day of WPI for 12 weeks. Anthropometric measurements, body composition analysis, and biochemical exams were performed at the beginning and end of the study. An increase in skeletal muscle mass was observed in the intervention group after 12 weeks. A reduction in waist circumference, body fat percentage, and an increase in skeletal muscle index was observed when compared to the placebo group. No significant effect on muscle strength was observed after 12 weeks of intervention. These data demonstrate that WPI consumption contributed to the increase of skeletal muscle mass, strength, and reduction of body fat in HF patients. |
| first_indexed | 2024-03-11T03:26:54Z |
| format | Article |
| id | doaj.art-e97d0f1561aa4d95b6ba01c05fe0f3ca |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T03:26:54Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e97d0f1561aa4d95b6ba01c05fe0f3ca2023-11-18T02:44:43ZengMDPI AGNutrients2072-66432023-05-011510232010.3390/nu15102320Effects of Whey Protein Isolate on Body Composition, Muscle Mass, and Strength of Chronic Heart Failure Patients: A Randomized Clinical TrialElisa M. dos Santos0Annie S. B. Moreira1Grazielle V. B. Huguenin2Eduardo Tibiriça3Andrea De Lorenzo4Institute of Heart Edson Saad, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, RJ, BrazilDepartment of Clinical Research, National Institute of Cardiology, Rio de Janeiro 22240-006, RJ, BrazilDepartamento de Nutrição e Dietética, Faculdade de Nutrição Emília de Jesus Ferreiro, Federal Fluminense University, Niterói 24020-140, RJ, BrazilDepartment of Clinical Research, National Institute of Cardiology, Rio de Janeiro 22240-006, RJ, BrazilInstitute of Heart Edson Saad, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, RJ, BrazilHeart failure (HF) is associated with a reduction of skeletal muscle mass. Whey protein isolate (WPI) has been beneficial in increasing muscle mass and strength, in addition to improving body composition. The goal of this research was to evaluate the effect of WPI on the body composition, muscle mass, and strength of chronic HF patients. For this purpose, twenty-five patients of both genders with predominantly NYHA I functional class and a median age of 65.5 (60.5–71.0) years were used to conduct a randomized, single-blind, placebo-controlled clinical trial and received 30 g per day of WPI for 12 weeks. Anthropometric measurements, body composition analysis, and biochemical exams were performed at the beginning and end of the study. An increase in skeletal muscle mass was observed in the intervention group after 12 weeks. A reduction in waist circumference, body fat percentage, and an increase in skeletal muscle index was observed when compared to the placebo group. No significant effect on muscle strength was observed after 12 weeks of intervention. These data demonstrate that WPI consumption contributed to the increase of skeletal muscle mass, strength, and reduction of body fat in HF patients.https://www.mdpi.com/2072-6643/15/10/2320heart failuredietwhey proteinsmuscle strengthrandomized clinical trial |
| spellingShingle | Elisa M. dos Santos Annie S. B. Moreira Grazielle V. B. Huguenin Eduardo Tibiriça Andrea De Lorenzo Effects of Whey Protein Isolate on Body Composition, Muscle Mass, and Strength of Chronic Heart Failure Patients: A Randomized Clinical Trial Nutrients heart failure diet whey proteins muscle strength randomized clinical trial |
| title | Effects of Whey Protein Isolate on Body Composition, Muscle Mass, and Strength of Chronic Heart Failure Patients: A Randomized Clinical Trial |
| title_full | Effects of Whey Protein Isolate on Body Composition, Muscle Mass, and Strength of Chronic Heart Failure Patients: A Randomized Clinical Trial |
| title_fullStr | Effects of Whey Protein Isolate on Body Composition, Muscle Mass, and Strength of Chronic Heart Failure Patients: A Randomized Clinical Trial |
| title_full_unstemmed | Effects of Whey Protein Isolate on Body Composition, Muscle Mass, and Strength of Chronic Heart Failure Patients: A Randomized Clinical Trial |
| title_short | Effects of Whey Protein Isolate on Body Composition, Muscle Mass, and Strength of Chronic Heart Failure Patients: A Randomized Clinical Trial |
| title_sort | effects of whey protein isolate on body composition muscle mass and strength of chronic heart failure patients a randomized clinical trial |
| topic | heart failure diet whey proteins muscle strength randomized clinical trial |
| url | https://www.mdpi.com/2072-6643/15/10/2320 |
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