White matter tracts contribute selectively to cognitive functioning in patients with glioma
ObjectiveThe functional organization of white matter (WM) tracts is not well characterized, especially in patients with intrinsic brain tumors where complex patterns of tissue injury, compression, and neuroplasticity may be present. This study uses diffusion tensor imaging (DTI) to investigate the r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1221753/full |
| _version_ | 1797654462026743808 |
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| author | Mia Andreoli Melissa-Ann Mackie David Aaby Matthew C. Tate |
| author_facet | Mia Andreoli Melissa-Ann Mackie David Aaby Matthew C. Tate |
| author_sort | Mia Andreoli |
| collection | DOAJ |
| description | ObjectiveThe functional organization of white matter (WM) tracts is not well characterized, especially in patients with intrinsic brain tumors where complex patterns of tissue injury, compression, and neuroplasticity may be present. This study uses diffusion tensor imaging (DTI) to investigate the relationships between WM tract disruption and cognitive deficits in glioma patients.MethodsSeventy-nine patients with glioma underwent preoperative DTI and neuropsychological testing. Thirteen WM tracts were reconstructed bilaterally. Fractional anisotropy and streamline number were obtained for each tract as indices of connectivity. Univariate regression models were used to model the association between WM tract connectivity and neuropsychological outcomes.ResultsGlioma patients exhibited variable injury to WM tracts and variable cognitive deficits on validated neuropsychological tests. We identified 16 age-adjusted associations between WM tract integrity and neuropsychological function. The left inferior frontal-occipital fasciculus (IFOF) predicted list learning and dominant-hand fine motor dexterity. The right IFOF predicted non-dominant-hand fine motor dexterity and visuospatial index scores. The left inferior longitudinal fasciculus (ILF) predicted immediate memory list learning and index scores. The right ILF predicted non-dominant-hand fine motor dexterity and backward digit span scores. The left superior longitudinal fasciculus (SLF) I predicted processing speed. The left SLF III predicted list learning, immediate memory index scores, phonemic fluency, and verbal abstract reasoning. The left cingulum predicted processing speed. The right anterior AF predicted verbal abstract reasoning.ConclusionWM tract disruption predicts cognitive dysfunction in glioma patients. By improving knowledge of WM tract organization, this analysis may guide maximum surgical resection and functional preservation in glioma patients. |
| first_indexed | 2024-03-11T16:59:49Z |
| format | Article |
| id | doaj.art-e97e5c35943149da8e456ed4fe9513ae |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-11T16:59:49Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e97e5c35943149da8e456ed4fe9513ae2023-10-20T12:51:38ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-10-011310.3389/fonc.2023.12217531221753White matter tracts contribute selectively to cognitive functioning in patients with gliomaMia Andreoli0Melissa-Ann Mackie1David Aaby2Matthew C. Tate3Feinberg School of Medicine, Northwestern University, Chicago, IL, United StatesDepartment of Neuropsychology, Northwestern Memorial Hospital, Chicago, IL, United StatesFeinberg School of Medicine, Northwestern University, Chicago, IL, United StatesDepartment of Neurological Surgery and Neurology, Northwestern Memorial Hospital, Chicago, IL, United StatesObjectiveThe functional organization of white matter (WM) tracts is not well characterized, especially in patients with intrinsic brain tumors where complex patterns of tissue injury, compression, and neuroplasticity may be present. This study uses diffusion tensor imaging (DTI) to investigate the relationships between WM tract disruption and cognitive deficits in glioma patients.MethodsSeventy-nine patients with glioma underwent preoperative DTI and neuropsychological testing. Thirteen WM tracts were reconstructed bilaterally. Fractional anisotropy and streamline number were obtained for each tract as indices of connectivity. Univariate regression models were used to model the association between WM tract connectivity and neuropsychological outcomes.ResultsGlioma patients exhibited variable injury to WM tracts and variable cognitive deficits on validated neuropsychological tests. We identified 16 age-adjusted associations between WM tract integrity and neuropsychological function. The left inferior frontal-occipital fasciculus (IFOF) predicted list learning and dominant-hand fine motor dexterity. The right IFOF predicted non-dominant-hand fine motor dexterity and visuospatial index scores. The left inferior longitudinal fasciculus (ILF) predicted immediate memory list learning and index scores. The right ILF predicted non-dominant-hand fine motor dexterity and backward digit span scores. The left superior longitudinal fasciculus (SLF) I predicted processing speed. The left SLF III predicted list learning, immediate memory index scores, phonemic fluency, and verbal abstract reasoning. The left cingulum predicted processing speed. The right anterior AF predicted verbal abstract reasoning.ConclusionWM tract disruption predicts cognitive dysfunction in glioma patients. By improving knowledge of WM tract organization, this analysis may guide maximum surgical resection and functional preservation in glioma patients.https://www.frontiersin.org/articles/10.3389/fonc.2023.1221753/fullgliomawhite matter tractsdiffusion tensor imagingfractional anisotropycognitive functionneuropsychology |
| spellingShingle | Mia Andreoli Melissa-Ann Mackie David Aaby Matthew C. Tate White matter tracts contribute selectively to cognitive functioning in patients with glioma Frontiers in Oncology glioma white matter tracts diffusion tensor imaging fractional anisotropy cognitive function neuropsychology |
| title | White matter tracts contribute selectively to cognitive functioning in patients with glioma |
| title_full | White matter tracts contribute selectively to cognitive functioning in patients with glioma |
| title_fullStr | White matter tracts contribute selectively to cognitive functioning in patients with glioma |
| title_full_unstemmed | White matter tracts contribute selectively to cognitive functioning in patients with glioma |
| title_short | White matter tracts contribute selectively to cognitive functioning in patients with glioma |
| title_sort | white matter tracts contribute selectively to cognitive functioning in patients with glioma |
| topic | glioma white matter tracts diffusion tensor imaging fractional anisotropy cognitive function neuropsychology |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1221753/full |
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