Immune thrombocytopenia associated with COVID-19 mRNA vaccine tozinameran – a clinical case and global pharmacovigilance data
We report the occurrence of immune thrombocytopenia (ITP) in a 77-year-old man a few days after receiving the first dose of the COVID-19 mRNA vaccine tozinameran (Comirnaty®). The patient was treated with systemic corticosteroids, intravenous immunoglobulins and eltrombopag. He elected to proceed...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2021-12-01
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| Series: | Swiss Medical Weekly |
| Online Access: | https://www.smw.ch/index.php/smw/article/view/3118 |
| _version_ | 1826995664939122688 |
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| author | Raphael Battegay Ioanna Istampoulouoglou Andreas Holbro Andreas Buser Julia R. Hirsiger Jens Eckstein Christoph T. Berger Sarah Koechlin Anne B. Leuppi-Taegtmeyer |
| author_facet | Raphael Battegay Ioanna Istampoulouoglou Andreas Holbro Andreas Buser Julia R. Hirsiger Jens Eckstein Christoph T. Berger Sarah Koechlin Anne B. Leuppi-Taegtmeyer |
| author_sort | Raphael Battegay |
| collection | DOAJ |
| description |
We report the occurrence of immune thrombocytopenia (ITP) in a 77-year-old man a few days after receiving the first dose of the COVID-19 mRNA vaccine tozinameran (Comirnaty®). The patient was treated with systemic corticosteroids, intravenous immunoglobulins and eltrombopag. He elected to proceed with the second dose of tozinameran 14 weeks after the first and his platelet count remained stable under a tapered eltrombopag dose. To our knowledge, this is the first case in which a second tozinameran dose has been administered to a patient who developed presumed secondary ITP after the first vaccination. We also report global pharmacovigilance data for the occurrence of ITP after vaccination with tozinameran.
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| first_indexed | 2024-04-11T04:27:40Z |
| format | Article |
| id | doaj.art-e97f5bcbb9614c36be9f1b20e9aa52a1 |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2025-02-18T09:35:47Z |
| publishDate | 2021-12-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-e97f5bcbb9614c36be9f1b20e9aa52a12024-11-02T17:41:18ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972021-12-01151495010.4414/SMW.2021.w30084Immune thrombocytopenia associated with COVID-19 mRNA vaccine tozinameran – a clinical case and global pharmacovigilance dataRaphael BattegayIoanna IstampoulouoglouAndreas HolbroAndreas BuserJulia R. HirsigerJens EcksteinChristoph T. BergerSarah KoechlinAnne B. Leuppi-Taegtmeyer We report the occurrence of immune thrombocytopenia (ITP) in a 77-year-old man a few days after receiving the first dose of the COVID-19 mRNA vaccine tozinameran (Comirnaty®). The patient was treated with systemic corticosteroids, intravenous immunoglobulins and eltrombopag. He elected to proceed with the second dose of tozinameran 14 weeks after the first and his platelet count remained stable under a tapered eltrombopag dose. To our knowledge, this is the first case in which a second tozinameran dose has been administered to a patient who developed presumed secondary ITP after the first vaccination. We also report global pharmacovigilance data for the occurrence of ITP after vaccination with tozinameran. https://www.smw.ch/index.php/smw/article/view/3118 |
| spellingShingle | Raphael Battegay Ioanna Istampoulouoglou Andreas Holbro Andreas Buser Julia R. Hirsiger Jens Eckstein Christoph T. Berger Sarah Koechlin Anne B. Leuppi-Taegtmeyer Immune thrombocytopenia associated with COVID-19 mRNA vaccine tozinameran – a clinical case and global pharmacovigilance data Swiss Medical Weekly |
| title | Immune thrombocytopenia associated with COVID-19 mRNA vaccine tozinameran – a clinical case and global pharmacovigilance data |
| title_full | Immune thrombocytopenia associated with COVID-19 mRNA vaccine tozinameran – a clinical case and global pharmacovigilance data |
| title_fullStr | Immune thrombocytopenia associated with COVID-19 mRNA vaccine tozinameran – a clinical case and global pharmacovigilance data |
| title_full_unstemmed | Immune thrombocytopenia associated with COVID-19 mRNA vaccine tozinameran – a clinical case and global pharmacovigilance data |
| title_short | Immune thrombocytopenia associated with COVID-19 mRNA vaccine tozinameran – a clinical case and global pharmacovigilance data |
| title_sort | immune thrombocytopenia associated with covid 19 mrna vaccine tozinameran a clinical case and global pharmacovigilance data |
| url | https://www.smw.ch/index.php/smw/article/view/3118 |
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