The interplay between the microbiota, diet and T regulatory cells in the preservation of the gut barrier in inflammatory bowel disease
Inflammatory bowel disease (IBD) is becoming more common in the Western world due to changes in diet-related microbial dysbiosis, genetics and lifestyle. Incidences of gut permeability can predate IBD and continued gut barrier disruptions increase the exposure of bacterial antigens to the immune sys...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-12-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1291724/full |
| _version_ | 1797435147474173952 |
|---|---|
| author | Kathryn Prame Kumar Joshua D. Ooi Rimma Goldberg |
| author_facet | Kathryn Prame Kumar Joshua D. Ooi Rimma Goldberg |
| author_sort | Kathryn Prame Kumar |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is becoming more common in the Western world due to changes in diet-related microbial dysbiosis, genetics and lifestyle. Incidences of gut permeability can predate IBD and continued gut barrier disruptions increase the exposure of bacterial antigens to the immune system thereby perpetuating chronic inflammation. Currently, most of the approved IBD therapies target individual pro-inflammatory cytokines and pathways. However, they fail in approximately 50% of patients due to their inability to overcome the redundant pro inflammatory immune responses. There is increasing interest in the therapeutic potential of T regulatory cells (Tregs) in inflammatory conditions due to their widespread capability to dampen inflammation, promote tolerance of intestinal bacteria, facilitate healing of the mucosal barrier and ability to be engineered for more targeted therapy. Intestinal Treg populations are inherently shaped by dietary molecules and gut microbiota-derived metabolites. Thus, understanding how these molecules influence Treg-mediated preservation of the intestinal barrier will provide insights into immune tolerance-mediated mucosal homeostasis. This review comprehensively explores the interplay between diet, gut microbiota, and immune system in influencing the intestinal barrier function to attenuate the progression of colitis. |
| first_indexed | 2024-03-09T10:43:03Z |
| format | Article |
| id | doaj.art-e982d770238546a0a339a815382ef0b7 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-09T10:43:03Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-e982d770238546a0a339a815382ef0b72023-12-01T13:15:08ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-12-011410.3389/fmicb.2023.12917241291724The interplay between the microbiota, diet and T regulatory cells in the preservation of the gut barrier in inflammatory bowel diseaseKathryn Prame KumarJoshua D. OoiRimma GoldbergInflammatory bowel disease (IBD) is becoming more common in the Western world due to changes in diet-related microbial dysbiosis, genetics and lifestyle. Incidences of gut permeability can predate IBD and continued gut barrier disruptions increase the exposure of bacterial antigens to the immune system thereby perpetuating chronic inflammation. Currently, most of the approved IBD therapies target individual pro-inflammatory cytokines and pathways. However, they fail in approximately 50% of patients due to their inability to overcome the redundant pro inflammatory immune responses. There is increasing interest in the therapeutic potential of T regulatory cells (Tregs) in inflammatory conditions due to their widespread capability to dampen inflammation, promote tolerance of intestinal bacteria, facilitate healing of the mucosal barrier and ability to be engineered for more targeted therapy. Intestinal Treg populations are inherently shaped by dietary molecules and gut microbiota-derived metabolites. Thus, understanding how these molecules influence Treg-mediated preservation of the intestinal barrier will provide insights into immune tolerance-mediated mucosal homeostasis. This review comprehensively explores the interplay between diet, gut microbiota, and immune system in influencing the intestinal barrier function to attenuate the progression of colitis.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1291724/fullinflammatory bowel diseaseT regulatory cellsgut permeabilitydietmicrobiota |
| spellingShingle | Kathryn Prame Kumar Joshua D. Ooi Rimma Goldberg The interplay between the microbiota, diet and T regulatory cells in the preservation of the gut barrier in inflammatory bowel disease Frontiers in Microbiology inflammatory bowel disease T regulatory cells gut permeability diet microbiota |
| title | The interplay between the microbiota, diet and T regulatory cells in the preservation of the gut barrier in inflammatory bowel disease |
| title_full | The interplay between the microbiota, diet and T regulatory cells in the preservation of the gut barrier in inflammatory bowel disease |
| title_fullStr | The interplay between the microbiota, diet and T regulatory cells in the preservation of the gut barrier in inflammatory bowel disease |
| title_full_unstemmed | The interplay between the microbiota, diet and T regulatory cells in the preservation of the gut barrier in inflammatory bowel disease |
| title_short | The interplay between the microbiota, diet and T regulatory cells in the preservation of the gut barrier in inflammatory bowel disease |
| title_sort | interplay between the microbiota diet and t regulatory cells in the preservation of the gut barrier in inflammatory bowel disease |
| topic | inflammatory bowel disease T regulatory cells gut permeability diet microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1291724/full |
| work_keys_str_mv | AT kathrynpramekumar theinterplaybetweenthemicrobiotadietandtregulatorycellsinthepreservationofthegutbarrierininflammatoryboweldisease AT joshuadooi theinterplaybetweenthemicrobiotadietandtregulatorycellsinthepreservationofthegutbarrierininflammatoryboweldisease AT rimmagoldberg theinterplaybetweenthemicrobiotadietandtregulatorycellsinthepreservationofthegutbarrierininflammatoryboweldisease AT kathrynpramekumar interplaybetweenthemicrobiotadietandtregulatorycellsinthepreservationofthegutbarrierininflammatoryboweldisease AT joshuadooi interplaybetweenthemicrobiotadietandtregulatorycellsinthepreservationofthegutbarrierininflammatoryboweldisease AT rimmagoldberg interplaybetweenthemicrobiotadietandtregulatorycellsinthepreservationofthegutbarrierininflammatoryboweldisease |