Medicinal plant reported with adverse reactions in Cuba: potential interactions with conventional drugs
Context: Herbal drugs are a mixture of active compounds and the chemical complexity of each formulation increase with the possibility of interactions between them and conventional drugs. Many mechanisms are implicated in the interactions; scientific community has dedicated the attentions to enzymes...
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| Format: | Article |
| Language: | English |
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GarVal Editorial Ltda.
2015-04-01
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| Series: | Journal of Pharmacy & Pharmacognosy Research |
| Subjects: | |
| Online Access: | http://jppres.com/jppres/pdf/vol3/jppres15.055_3.2.37.pdf |
| _version_ | 1811260461107118080 |
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| author | Ioanna Martínez Ana I. Garcia Idania Rodeiro Francisco Morón |
| author_facet | Ioanna Martínez Ana I. Garcia Idania Rodeiro Francisco Morón |
| author_sort | Ioanna Martínez |
| collection | DOAJ |
| description | Context: Herbal drugs are a mixture of active compounds and the chemical complexity of each formulation increase with the possibility of interactions between them and conventional drugs. Many mechanisms are implicated in the interactions; scientific community has dedicated the attentions to enzymes as P-gp and CYP450.
Aims: To investigate in the literature the principal plants with suspicions of adverse reactions in Cuba and their potential interactions with conventional drugs.
Methods: PubMed was the database used as source of information until February 2014. Key words: Herb-Drug, Drug-Plant, Herbal–Drug, Interactions with scientific names of plants was used. Information was structured and analysed with EndNote X4.
Analysis and integration of the information: Allium sativum L. (garlic) was the plant with the high number of studies related with CYP450 and P-gp. Plants with great demand as Morinda citrifolia L. (noni), Psidium guajava L. (guayaba), Zingiber officinale Roscoe (ginger) and Eucalyptus spp. (eucalyptus) have a very small number of studies. The professionals of the health should keep in mind the possibility of interactions between herbal products and conventional drugs to increase the effectiveness of phytotherapy.
Conclusions: It is necessary enhance reports and investigations and to put to disposition of the system of health information on the interactions of plants and to stimulate the investigation that offers information for the rational use of our medicinal plants. |
| first_indexed | 2024-04-12T18:47:44Z |
| format | Article |
| id | doaj.art-e9838a7371e84615ab36825a9a4a8877 |
| institution | Directory Open Access Journal |
| issn | 0719-4250 |
| language | English |
| last_indexed | 2024-04-12T18:47:44Z |
| publishDate | 2015-04-01 |
| publisher | GarVal Editorial Ltda. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmacognosy Research |
| spelling | doaj.art-e9838a7371e84615ab36825a9a4a88772022-12-22T03:20:34ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502015-04-01323344Medicinal plant reported with adverse reactions in Cuba: potential interactions with conventional drugsIoanna Martínez 0Ana I. Garcia1Idania Rodeiro2Francisco Morón3Laboratorio Central de Farmacología “Dr. Francisco Morón In Memoriam”, Facultad de Ciencias Médicas “Dr. Salvador Allende”, Carvajal entre Agua Dulce y A, Cerro, P.O. Box 12000, La Habana, CubaLaboratorio Central de Farmacología “Dr. Francisco Morón In Memoriam”, Facultad de Ciencias Médicas “Dr. Salvador Allende”, Carvajal entre Agua Dulce y A, Cerro, P.O. Box 12000, La Habana, CubaDepartamento de Farmacología, Centro de Bioproductos Marinos (CEBIMAR), Loma y 37, Vedado, P.O. Box 10400, La Habana, CubaLaboratorio Central de Farmacología “Dr. Francisco Morón In Memoriam”, Facultad de Ciencias Médicas “Dr. Salvador Allende”, Carvajal entre Agua Dulce y A, Cerro, P.O. Box 12000, La Habana, CubaContext: Herbal drugs are a mixture of active compounds and the chemical complexity of each formulation increase with the possibility of interactions between them and conventional drugs. Many mechanisms are implicated in the interactions; scientific community has dedicated the attentions to enzymes as P-gp and CYP450. Aims: To investigate in the literature the principal plants with suspicions of adverse reactions in Cuba and their potential interactions with conventional drugs. Methods: PubMed was the database used as source of information until February 2014. Key words: Herb-Drug, Drug-Plant, Herbal–Drug, Interactions with scientific names of plants was used. Information was structured and analysed with EndNote X4. Analysis and integration of the information: Allium sativum L. (garlic) was the plant with the high number of studies related with CYP450 and P-gp. Plants with great demand as Morinda citrifolia L. (noni), Psidium guajava L. (guayaba), Zingiber officinale Roscoe (ginger) and Eucalyptus spp. (eucalyptus) have a very small number of studies. The professionals of the health should keep in mind the possibility of interactions between herbal products and conventional drugs to increase the effectiveness of phytotherapy. Conclusions: It is necessary enhance reports and investigations and to put to disposition of the system of health information on the interactions of plants and to stimulate the investigation that offers information for the rational use of our medicinal plants.http://jppres.com/jppres/pdf/vol3/jppres15.055_3.2.37.pdfCYP450drugsinteractionsmedicinal plantsP-gpplantas medicinalesinteracciones |
| spellingShingle | Ioanna Martínez Ana I. Garcia Idania Rodeiro Francisco Morón Medicinal plant reported with adverse reactions in Cuba: potential interactions with conventional drugs Journal of Pharmacy & Pharmacognosy Research CYP450 drugs interactions medicinal plants P-gp plantas medicinales interacciones |
| title | Medicinal plant reported with adverse reactions in Cuba: potential interactions with conventional drugs |
| title_full | Medicinal plant reported with adverse reactions in Cuba: potential interactions with conventional drugs |
| title_fullStr | Medicinal plant reported with adverse reactions in Cuba: potential interactions with conventional drugs |
| title_full_unstemmed | Medicinal plant reported with adverse reactions in Cuba: potential interactions with conventional drugs |
| title_short | Medicinal plant reported with adverse reactions in Cuba: potential interactions with conventional drugs |
| title_sort | medicinal plant reported with adverse reactions in cuba potential interactions with conventional drugs |
| topic | CYP450 drugs interactions medicinal plants P-gp plantas medicinales interacciones |
| url | http://jppres.com/jppres/pdf/vol3/jppres15.055_3.2.37.pdf |
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