Prevalence of age-related macular degeneration in Iran and its projections through 2050: a systematic review and meta-analysis
Abstract Background Age-related Macular Degeneration (AMD) is one of the most common causes of vision loss. A substantial increase in the burden of AMD is expected in the aging populations, including the Iranians. We investigated the age and gender-specific prevalence of AMD and its determinants in...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-023-03218-3 |
| _version_ | 1797453510683394048 |
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| author | Amirhossein Roshanshad Romina Roshanshad Seyed Ali Moosavi Ali Ardekani Sara Sadat Nabavizadeh Reza Fereidooni Hossein Ashraf Hossein Molavi Vardanjani |
| author_facet | Amirhossein Roshanshad Romina Roshanshad Seyed Ali Moosavi Ali Ardekani Sara Sadat Nabavizadeh Reza Fereidooni Hossein Ashraf Hossein Molavi Vardanjani |
| author_sort | Amirhossein Roshanshad |
| collection | DOAJ |
| description | Abstract Background Age-related Macular Degeneration (AMD) is one of the most common causes of vision loss. A substantial increase in the burden of AMD is expected in the aging populations, including the Iranians. We investigated the age and gender-specific prevalence of AMD and its determinants in Iran. Methods We systematically searched international (PubMed, Scopus, Embase, etc.) and local (IranDoc, Magiran, etc.) online databases. We included cross-sectional or cohort studies, either clinic- or population-based, published on the prevalence of AMD among Iranians, with no limitation on age. Joanna Briggs Institute (JBI) tools for critical appraisal were used. Prevalence estimates are pooled by applying random-effects modeling. Subgroup analysis and meta-regression were performed. Results Seventeen studies with 16,120 participants were included. Based on studies in general population, the pooled prevalence of AMD was 10.8% (95% CI: 6.5-16.2%) in males, and 9.8% (95% CI: 4.7-16.4%) in females. 8.5% of moderate vision impaired, 13.6% of severe vision impaired, and 15.7% of blind participants were affected by AMD. The prevalence of AMD was 2% in 40–49, and 32.3% in the ≥ 80 population. The prevalence of AMD was 11.9% among the visually impaired vs. 8.7% in the general population. The study’s sampling method, location, and mean age were correlated with the heterogeneities of the prevalence. We observed an increasing trend in the number of AMD cases (average annual percent change = 3.66%; 95% CI: 3.65–3.67%) from 1990 to 2050. The expected number of AMD cases in Iran will be near 5.5 million by 2050. Conclusion The prevalence of AMD in Iran was somewhere between the prevalence of Asians and Europeans. Given the aging trend of the Iranian community and an average annual percent change of 3.66%, it is indispensable to adopt preventive and screening policies to diminish the burden of the disease in the future decades. |
| first_indexed | 2024-03-09T15:23:53Z |
| format | Article |
| id | doaj.art-e9841c6d0d074fd0ae71da34368ab402 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-03-09T15:23:53Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-e9841c6d0d074fd0ae71da34368ab4022023-11-26T12:39:53ZengBMCBMC Ophthalmology1471-24152023-11-0123111310.1186/s12886-023-03218-3Prevalence of age-related macular degeneration in Iran and its projections through 2050: a systematic review and meta-analysisAmirhossein Roshanshad0Romina Roshanshad1Seyed Ali Moosavi2Ali Ardekani3Sara Sadat Nabavizadeh4Reza Fereidooni5Hossein Ashraf6Hossein Molavi Vardanjani7Poostchi Ophthalmology Research Center, Shiraz University of Medical SciencesStudent Research Committee, Shiraz University of Medical SciencesStudent Research Committee, Shiraz University of Medical SciencesSchool of Medicine, Shiraz University of Medical SciencesStudent Research Committee, Shiraz University of Medical SciencesHealth Policy Research Center, Institute of Health, Shiraz University of Medical SciencesPoostchi Ophthalmology Research Center, Shiraz University of Medical SciencesMPH Department, Shiraz University of Medical SciencesAbstract Background Age-related Macular Degeneration (AMD) is one of the most common causes of vision loss. A substantial increase in the burden of AMD is expected in the aging populations, including the Iranians. We investigated the age and gender-specific prevalence of AMD and its determinants in Iran. Methods We systematically searched international (PubMed, Scopus, Embase, etc.) and local (IranDoc, Magiran, etc.) online databases. We included cross-sectional or cohort studies, either clinic- or population-based, published on the prevalence of AMD among Iranians, with no limitation on age. Joanna Briggs Institute (JBI) tools for critical appraisal were used. Prevalence estimates are pooled by applying random-effects modeling. Subgroup analysis and meta-regression were performed. Results Seventeen studies with 16,120 participants were included. Based on studies in general population, the pooled prevalence of AMD was 10.8% (95% CI: 6.5-16.2%) in males, and 9.8% (95% CI: 4.7-16.4%) in females. 8.5% of moderate vision impaired, 13.6% of severe vision impaired, and 15.7% of blind participants were affected by AMD. The prevalence of AMD was 2% in 40–49, and 32.3% in the ≥ 80 population. The prevalence of AMD was 11.9% among the visually impaired vs. 8.7% in the general population. The study’s sampling method, location, and mean age were correlated with the heterogeneities of the prevalence. We observed an increasing trend in the number of AMD cases (average annual percent change = 3.66%; 95% CI: 3.65–3.67%) from 1990 to 2050. The expected number of AMD cases in Iran will be near 5.5 million by 2050. Conclusion The prevalence of AMD in Iran was somewhere between the prevalence of Asians and Europeans. Given the aging trend of the Iranian community and an average annual percent change of 3.66%, it is indispensable to adopt preventive and screening policies to diminish the burden of the disease in the future decades.https://doi.org/10.1186/s12886-023-03218-3AMDEpidemiologyIranMacular DegenerationMiddle EastPrevalence |
| spellingShingle | Amirhossein Roshanshad Romina Roshanshad Seyed Ali Moosavi Ali Ardekani Sara Sadat Nabavizadeh Reza Fereidooni Hossein Ashraf Hossein Molavi Vardanjani Prevalence of age-related macular degeneration in Iran and its projections through 2050: a systematic review and meta-analysis BMC Ophthalmology AMD Epidemiology Iran Macular Degeneration Middle East Prevalence |
| title | Prevalence of age-related macular degeneration in Iran and its projections through 2050: a systematic review and meta-analysis |
| title_full | Prevalence of age-related macular degeneration in Iran and its projections through 2050: a systematic review and meta-analysis |
| title_fullStr | Prevalence of age-related macular degeneration in Iran and its projections through 2050: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of age-related macular degeneration in Iran and its projections through 2050: a systematic review and meta-analysis |
| title_short | Prevalence of age-related macular degeneration in Iran and its projections through 2050: a systematic review and meta-analysis |
| title_sort | prevalence of age related macular degeneration in iran and its projections through 2050 a systematic review and meta analysis |
| topic | AMD Epidemiology Iran Macular Degeneration Middle East Prevalence |
| url | https://doi.org/10.1186/s12886-023-03218-3 |
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