Fibrotic Diseases of the Human Urinary and Genital Tract: Current Understanding and Potential Strategies for Treatment
Fibrosis is a disease condition characterized by abnormalities of the extracellular matrix, such as accumulation of the transforming growth factor β, infiltration by myofibroblasts, deposition of collagen, and a generalized dysregulation of collagen maturation. It can severely impair the function of...
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/14/4770 |
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| author | Harrina E. Rahardjo Viktoria Märker Dimitrios Tsikas Markus A. Kuczyk Stefan Ückert Andreas Bannowsky |
| author_facet | Harrina E. Rahardjo Viktoria Märker Dimitrios Tsikas Markus A. Kuczyk Stefan Ückert Andreas Bannowsky |
| author_sort | Harrina E. Rahardjo |
| collection | DOAJ |
| description | Fibrosis is a disease condition characterized by abnormalities of the extracellular matrix, such as accumulation of the transforming growth factor β, infiltration by myofibroblasts, deposition of collagen, and a generalized dysregulation of collagen maturation. It can severely impair the function of organs by replacing normal tissue with a highly collagenized matrix, thereby reducing the elasticity and compliance of tissues. Fibrotic diseases of the genitourinary tract present relevant problems in healthcare, and their principles of pathophysiology remain unclarified; hence, the armamentarium for prevention and treatment is limited. These diseases include renal fibrosis, Peyronie’s disease and ureteral and urethral strictures due to perturbations in the process of wound healing in response to injuries. Such deteriorations may contribute to obstructive uropathies or sexual dysfunction. This review provides a brief overview of the most frequent fibrotic diseases of the genitourinary system and of how the pathophysiology is related to symptoms, and also highlights potential therapeutic strategies to address the abnormal deposition of collagen. Although the understanding of factors associated with fibrotic conditions of the urinary and genital tract is still limited, some beneficial advances have been made. Further research will serve to provide a more comprehensive insight into factors responsible for the development of fibrotic tissue deposition. |
| first_indexed | 2024-03-11T00:58:11Z |
| format | Article |
| id | doaj.art-e985097b86ff438d9505a0994d07bfbd |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:58:11Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-e985097b86ff438d9505a0994d07bfbd2023-11-18T19:53:42ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011214477010.3390/jcm12144770Fibrotic Diseases of the Human Urinary and Genital Tract: Current Understanding and Potential Strategies for TreatmentHarrina E. Rahardjo0Viktoria Märker1Dimitrios Tsikas2Markus A. Kuczyk3Stefan Ückert4Andreas Bannowsky5Department of Urology, Cipto Mangunkusumo Hospital, School of Medicine, University of Indonesia, Jakarta 10430, IndonesiaDepartment of Forensic Psychiatry, University Hospital Hamburg-Eppendorf (UKE), 20251 Hamburg, GermanyCore Unit Proteomics, Center of Pharmacology & Toxicology, Hannover Medical School, 30625 Hannover, GermanyDepartment of Urology & Urological Oncology, Division of Surgery, Hannover Medical School, 30625 Hannover, GermanyDepartment of Urology & Urological Oncology, Division of Surgery, Hannover Medical School, 30625 Hannover, GermanyDepartment of Urology, Imland Hospital gGmbH, 24768 Rendsburg, GermanyFibrosis is a disease condition characterized by abnormalities of the extracellular matrix, such as accumulation of the transforming growth factor β, infiltration by myofibroblasts, deposition of collagen, and a generalized dysregulation of collagen maturation. It can severely impair the function of organs by replacing normal tissue with a highly collagenized matrix, thereby reducing the elasticity and compliance of tissues. Fibrotic diseases of the genitourinary tract present relevant problems in healthcare, and their principles of pathophysiology remain unclarified; hence, the armamentarium for prevention and treatment is limited. These diseases include renal fibrosis, Peyronie’s disease and ureteral and urethral strictures due to perturbations in the process of wound healing in response to injuries. Such deteriorations may contribute to obstructive uropathies or sexual dysfunction. This review provides a brief overview of the most frequent fibrotic diseases of the genitourinary system and of how the pathophysiology is related to symptoms, and also highlights potential therapeutic strategies to address the abnormal deposition of collagen. Although the understanding of factors associated with fibrotic conditions of the urinary and genital tract is still limited, some beneficial advances have been made. Further research will serve to provide a more comprehensive insight into factors responsible for the development of fibrotic tissue deposition.https://www.mdpi.com/2077-0383/12/14/4770urologyfibrotic diseasespathophysiologytreatment strategies |
| spellingShingle | Harrina E. Rahardjo Viktoria Märker Dimitrios Tsikas Markus A. Kuczyk Stefan Ückert Andreas Bannowsky Fibrotic Diseases of the Human Urinary and Genital Tract: Current Understanding and Potential Strategies for Treatment Journal of Clinical Medicine urology fibrotic diseases pathophysiology treatment strategies |
| title | Fibrotic Diseases of the Human Urinary and Genital Tract: Current Understanding and Potential Strategies for Treatment |
| title_full | Fibrotic Diseases of the Human Urinary and Genital Tract: Current Understanding and Potential Strategies for Treatment |
| title_fullStr | Fibrotic Diseases of the Human Urinary and Genital Tract: Current Understanding and Potential Strategies for Treatment |
| title_full_unstemmed | Fibrotic Diseases of the Human Urinary and Genital Tract: Current Understanding and Potential Strategies for Treatment |
| title_short | Fibrotic Diseases of the Human Urinary and Genital Tract: Current Understanding and Potential Strategies for Treatment |
| title_sort | fibrotic diseases of the human urinary and genital tract current understanding and potential strategies for treatment |
| topic | urology fibrotic diseases pathophysiology treatment strategies |
| url | https://www.mdpi.com/2077-0383/12/14/4770 |
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