Effect of Clinacanthus nutans leaf chloroform extract on reducing nitric oxide in fibroblasts
Background: Clinacanthus nutans or dandang gendis is a plant that can be an effective herbal treatment for inflammation, in addition the Indonesian people are still looking for alternative treatments. Research shows that the antiinflammatory properties of C. nutans leaves are effective in reducing i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Scientific Dental Journal |
| Subjects: | |
| Online Access: | http://www.scidentj.com/article.asp?issn=2580-6548;year=2023;volume=7;issue=3;spage=120;epage=124;aulast=Hapsari |
| _version_ | 1827309311631556608 |
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| author | Erdita Hapsari Rezky Anggraeni Komariah Komariah Moehamad Orliando Roeslan |
| author_facet | Erdita Hapsari Rezky Anggraeni Komariah Komariah Moehamad Orliando Roeslan |
| author_sort | Erdita Hapsari |
| collection | DOAJ |
| description | Background: Clinacanthus nutans or dandang gendis is a plant that can be an effective herbal treatment for inflammation, in addition the Indonesian people are still looking for alternative treatments. Research shows that the antiinflammatory properties of C. nutans leaves are effective in reducing inflammation against fibroblasts. Nitric oxide (NO) is one of the inflammatory mediators, that are released by fibroblast when inflamed. Objective: To observe the effect of C. nutans leaf chloroform extract on reducing NO in inflamed fibroblasts. Methods: Fibroblasts stimulated with Escherichia coli lipopolysaccharide were treated with chloroform extracts of C. nutans leaves at concentrations of 25, 50, 100, and 200 μg/mL for 24 h, then a NO inhibition test was performed. Result: The C. nutans leaf extract at a concentration of 200 μg/mL resulted in significantly (P < 0.05) lower NO production than the negative control. Conclusion: C. nutans leaf chloroform extract has the effect of reducing NO in fibroblasts. This extract has the potential as an antiinflammatory agent. |
| first_indexed | 2024-04-24T19:36:58Z |
| format | Article |
| id | doaj.art-e9896efd859842a59284a045b4bebd9e |
| institution | Directory Open Access Journal |
| issn | 2580-6548 2541-321X |
| language | English |
| last_indexed | 2024-04-24T19:36:58Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Scientific Dental Journal |
| spelling | doaj.art-e9896efd859842a59284a045b4bebd9e2024-03-25T13:06:48ZengWolters Kluwer Medknow PublicationsScientific Dental Journal2580-65482541-321X2023-01-017312012410.4103/SDJ.SDJ_9_23Effect of Clinacanthus nutans leaf chloroform extract on reducing nitric oxide in fibroblastsErdita HapsariRezky AnggraeniKomariah KomariahMoehamad Orliando RoeslanBackground: Clinacanthus nutans or dandang gendis is a plant that can be an effective herbal treatment for inflammation, in addition the Indonesian people are still looking for alternative treatments. Research shows that the antiinflammatory properties of C. nutans leaves are effective in reducing inflammation against fibroblasts. Nitric oxide (NO) is one of the inflammatory mediators, that are released by fibroblast when inflamed. Objective: To observe the effect of C. nutans leaf chloroform extract on reducing NO in inflamed fibroblasts. Methods: Fibroblasts stimulated with Escherichia coli lipopolysaccharide were treated with chloroform extracts of C. nutans leaves at concentrations of 25, 50, 100, and 200 μg/mL for 24 h, then a NO inhibition test was performed. Result: The C. nutans leaf extract at a concentration of 200 μg/mL resulted in significantly (P < 0.05) lower NO production than the negative control. Conclusion: C. nutans leaf chloroform extract has the effect of reducing NO in fibroblasts. This extract has the potential as an antiinflammatory agent.http://www.scidentj.com/article.asp?issn=2580-6548;year=2023;volume=7;issue=3;spage=120;epage=124;aulast=Hapsaridandang gendis (clinacanthus nutans)fibroblastsnitric oxide |
| spellingShingle | Erdita Hapsari Rezky Anggraeni Komariah Komariah Moehamad Orliando Roeslan Effect of Clinacanthus nutans leaf chloroform extract on reducing nitric oxide in fibroblasts Scientific Dental Journal dandang gendis (clinacanthus nutans) fibroblasts nitric oxide |
| title | Effect of Clinacanthus nutans leaf chloroform extract on reducing nitric oxide in fibroblasts |
| title_full | Effect of Clinacanthus nutans leaf chloroform extract on reducing nitric oxide in fibroblasts |
| title_fullStr | Effect of Clinacanthus nutans leaf chloroform extract on reducing nitric oxide in fibroblasts |
| title_full_unstemmed | Effect of Clinacanthus nutans leaf chloroform extract on reducing nitric oxide in fibroblasts |
| title_short | Effect of Clinacanthus nutans leaf chloroform extract on reducing nitric oxide in fibroblasts |
| title_sort | effect of clinacanthus nutans leaf chloroform extract on reducing nitric oxide in fibroblasts |
| topic | dandang gendis (clinacanthus nutans) fibroblasts nitric oxide |
| url | http://www.scidentj.com/article.asp?issn=2580-6548;year=2023;volume=7;issue=3;spage=120;epage=124;aulast=Hapsari |
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