Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy
IntroductionCerebral Palsy (CP) is the most common neurodevelopmental motor disability, resulting in life-long sensory, perception and motor impairments. Moreover, these impairments appear to drastically worsen as the population with CP transitions from adolescents to adulthood, although the underly...
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| Format: | Article |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1163964/full |
| _version_ | 1797780865492713472 |
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| author | Hannah Bergwell Michael P. Trevarrow Elizabeth Heinrichs-Graham Elizabeth Heinrichs-Graham Anna Reelfs Lauren R. Ott Samantha H. Penhale Tony W. Wilson Tony W. Wilson Max J. Kurz Max J. Kurz |
| author_facet | Hannah Bergwell Michael P. Trevarrow Elizabeth Heinrichs-Graham Elizabeth Heinrichs-Graham Anna Reelfs Lauren R. Ott Samantha H. Penhale Tony W. Wilson Tony W. Wilson Max J. Kurz Max J. Kurz |
| author_sort | Hannah Bergwell |
| collection | DOAJ |
| description | IntroductionCerebral Palsy (CP) is the most common neurodevelopmental motor disability, resulting in life-long sensory, perception and motor impairments. Moreover, these impairments appear to drastically worsen as the population with CP transitions from adolescents to adulthood, although the underlying neurophysiological mechanisms remain poorly understood.MethodsWe began to address this knowledge gap by utilizing magnetoencephalographic (MEG) brain imaging to study how the amplitude of spontaneous cortical activity (i.e., resting state) is altered during this transition period in a cohort of 38 individuals with spastic diplegic CP (Age range = 9.80–47.50 years, 20 females) and 67 neurotypical controls (NT) (Age range = 9.08–49.40 years, Females = 27). MEG data from a five-minute eyes closed resting-state paradigm were source imaged, and the power within the delta (2–4 Hz), theta (5–7 Hz), alpha (8–12 Hz), beta (15–29 Hz), and gamma (30–59 Hz) frequency bands were computed.ResultsFor both groups, the delta and theta spontaneous power decreased in the bilateral temporoparietal and superior parietal regions with age, while alpha, beta, and gamma band spontaneous power increased in temporoparietal, frontoparietal and premotor regions with age. We also found a significant group x age interaction, such that participants with CP demonstrated significantly less age-related increases in the spontaneous beta activity in the bilateral sensorimotor cortices compared to NT controls.DiscussionOverall, these results demonstrate that the spontaneous neural activity in individuals with CP has an altered trajectory when transitioning from adolescents to adulthood. We suggest that these differences in spontaneous cortical activity may play a critical role in the aberrant motor actions seen in this patient group, and may provide a neurophysiological marker for assessing the effectiveness of current treatment strategies that are directed at improving the mobility and sensorimotor impairments seen in individuals with CP. |
| first_indexed | 2024-03-12T23:49:50Z |
| format | Article |
| id | doaj.art-e989d30fded240a6b4916dd472ec40e2 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-12T23:49:50Z |
| publishDate | 2023-07-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-e989d30fded240a6b4916dd472ec40e22023-07-13T19:30:19ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-07-011410.3389/fneur.2023.11639641163964Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsyHannah Bergwell0Michael P. Trevarrow1Elizabeth Heinrichs-Graham2Elizabeth Heinrichs-Graham3Anna Reelfs4Lauren R. Ott5Samantha H. Penhale6Tony W. Wilson7Tony W. Wilson8Max J. Kurz9Max J. Kurz10Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, United StatesInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, United StatesInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, United StatesDepartment of Pharmacology & Neuroscience, Creighton University, Omaha, NE, United StatesInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, United StatesInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, United StatesInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, United StatesInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, United StatesDepartment of Pharmacology & Neuroscience, Creighton University, Omaha, NE, United StatesInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, United StatesDepartment of Pharmacology & Neuroscience, Creighton University, Omaha, NE, United StatesIntroductionCerebral Palsy (CP) is the most common neurodevelopmental motor disability, resulting in life-long sensory, perception and motor impairments. Moreover, these impairments appear to drastically worsen as the population with CP transitions from adolescents to adulthood, although the underlying neurophysiological mechanisms remain poorly understood.MethodsWe began to address this knowledge gap by utilizing magnetoencephalographic (MEG) brain imaging to study how the amplitude of spontaneous cortical activity (i.e., resting state) is altered during this transition period in a cohort of 38 individuals with spastic diplegic CP (Age range = 9.80–47.50 years, 20 females) and 67 neurotypical controls (NT) (Age range = 9.08–49.40 years, Females = 27). MEG data from a five-minute eyes closed resting-state paradigm were source imaged, and the power within the delta (2–4 Hz), theta (5–7 Hz), alpha (8–12 Hz), beta (15–29 Hz), and gamma (30–59 Hz) frequency bands were computed.ResultsFor both groups, the delta and theta spontaneous power decreased in the bilateral temporoparietal and superior parietal regions with age, while alpha, beta, and gamma band spontaneous power increased in temporoparietal, frontoparietal and premotor regions with age. We also found a significant group x age interaction, such that participants with CP demonstrated significantly less age-related increases in the spontaneous beta activity in the bilateral sensorimotor cortices compared to NT controls.DiscussionOverall, these results demonstrate that the spontaneous neural activity in individuals with CP has an altered trajectory when transitioning from adolescents to adulthood. We suggest that these differences in spontaneous cortical activity may play a critical role in the aberrant motor actions seen in this patient group, and may provide a neurophysiological marker for assessing the effectiveness of current treatment strategies that are directed at improving the mobility and sensorimotor impairments seen in individuals with CP.https://www.frontiersin.org/articles/10.3389/fneur.2023.1163964/fullmagnetoencephalographyresting statesensorimotorbetaneuroimaging |
| spellingShingle | Hannah Bergwell Michael P. Trevarrow Elizabeth Heinrichs-Graham Elizabeth Heinrichs-Graham Anna Reelfs Lauren R. Ott Samantha H. Penhale Tony W. Wilson Tony W. Wilson Max J. Kurz Max J. Kurz Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy Frontiers in Neurology magnetoencephalography resting state sensorimotor beta neuroimaging |
| title | Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy |
| title_full | Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy |
| title_fullStr | Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy |
| title_full_unstemmed | Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy |
| title_short | Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy |
| title_sort | aberrant age related alterations in spontaneous cortical activity in participants with cerebral palsy |
| topic | magnetoencephalography resting state sensorimotor beta neuroimaging |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1163964/full |
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