Correlation of cord blood telomere length with birth weight
Abstract Background Intrauterine growth restriction affects 3% of newborns; and the lightest 10% of whom are classified as small for gestational age (SGA). These low-birth weight newborns are at increased risk of neonatal morbidity such as hypoxia and hypoglycaemia. In later life, they are at higher...
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| Format: | Article |
| Language: | English |
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BMC
2017-09-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-017-2791-6 |
| _version_ | 1831756744222572544 |
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| author | Siew-Peng Lee Prakash Hande George SH Yeo Ene-Choo Tan |
| author_facet | Siew-Peng Lee Prakash Hande George SH Yeo Ene-Choo Tan |
| author_sort | Siew-Peng Lee |
| collection | DOAJ |
| description | Abstract Background Intrauterine growth restriction affects 3% of newborns; and the lightest 10% of whom are classified as small for gestational age (SGA). These low-birth weight newborns are at increased risk of neonatal morbidity such as hypoxia and hypoglycaemia. In later life, they are at higher risk of several age-related diseases such as cardiovascular and metabolic disorders and dementia. As having short telomeres is also associated with these diseases, we tested if these newborns might already start with shorter telomeres at birth. Findings Relative telomere lengths were determined using quantitative real-time PCR in cord blood samples from 195 newborns of Chinese ancestry. Based on the telomere length normalised to a single copy gene and a reference DNA sample as internal control, we found statistically significant correlations between relative telomere length and both unadjusted and gestational age-adjusted birth weight, with the lighter newborns having shorter telomeres. The SGA birth weight group comprising the bottom 10% of the samples also had the shortest telomeres compared to the medium and heaviest birth weight groups. Conclusions Our results indicate that there is reduction of cord blood telomere length for newborns with lower birth weight. |
| first_indexed | 2024-12-22T00:18:08Z |
| format | Article |
| id | doaj.art-e989d9b201894d07a7182089d01981bf |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-22T00:18:08Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-e989d9b201894d07a7182089d01981bf2022-12-21T18:45:14ZengBMCBMC Research Notes1756-05002017-09-011011610.1186/s13104-017-2791-6Correlation of cord blood telomere length with birth weightSiew-Peng Lee0Prakash Hande1George SH Yeo2Ene-Choo Tan3Research Laboratory, KK Women’s and Children’s HospitalDepartment of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeMaternal–Fetal Medicine, KK Women’s and Children’s HospitalResearch Laboratory, KK Women’s and Children’s HospitalAbstract Background Intrauterine growth restriction affects 3% of newborns; and the lightest 10% of whom are classified as small for gestational age (SGA). These low-birth weight newborns are at increased risk of neonatal morbidity such as hypoxia and hypoglycaemia. In later life, they are at higher risk of several age-related diseases such as cardiovascular and metabolic disorders and dementia. As having short telomeres is also associated with these diseases, we tested if these newborns might already start with shorter telomeres at birth. Findings Relative telomere lengths were determined using quantitative real-time PCR in cord blood samples from 195 newborns of Chinese ancestry. Based on the telomere length normalised to a single copy gene and a reference DNA sample as internal control, we found statistically significant correlations between relative telomere length and both unadjusted and gestational age-adjusted birth weight, with the lighter newborns having shorter telomeres. The SGA birth weight group comprising the bottom 10% of the samples also had the shortest telomeres compared to the medium and heaviest birth weight groups. Conclusions Our results indicate that there is reduction of cord blood telomere length for newborns with lower birth weight.http://link.springer.com/article/10.1186/s13104-017-2791-6Birth weightNewbornsQuantitative PCRTelomere length |
| spellingShingle | Siew-Peng Lee Prakash Hande George SH Yeo Ene-Choo Tan Correlation of cord blood telomere length with birth weight BMC Research Notes Birth weight Newborns Quantitative PCR Telomere length |
| title | Correlation of cord blood telomere length with birth weight |
| title_full | Correlation of cord blood telomere length with birth weight |
| title_fullStr | Correlation of cord blood telomere length with birth weight |
| title_full_unstemmed | Correlation of cord blood telomere length with birth weight |
| title_short | Correlation of cord blood telomere length with birth weight |
| title_sort | correlation of cord blood telomere length with birth weight |
| topic | Birth weight Newborns Quantitative PCR Telomere length |
| url | http://link.springer.com/article/10.1186/s13104-017-2791-6 |
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