ATM polymorphisms IVS24-9delT, IVS38-8T>C, and 5557G>A in Mexican women with familial and/or early-onset breast cancer
Objective. To assess whether in Mexican population the frequencies of ATM polymorphisms IVS24-9delT, IVS38-8T mayor que C, and 5557G mayor que A in breast cancer (BC) cases and healthy controls were different from those found in other countries. Materials and methods. Frequencies of polymorphisms co...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Instituto Nacional de Salud Pública
2014-03-01
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| Series: | Salud Pública de México |
| Subjects: | |
| Online Access: | http://www.saludpublica.mx/index.php/spm/article/view/7336 |
| _version_ | 1818520240316743680 |
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| author | Fabiola del Carmen Calderón-Zúñiga Guadalupe Ocampo-Gómez Francisco Carlos López-Márquez Rogelio Recio-Vega Luis Benjamín Serrano-Gallardo Pablo Ruiz-Flores |
| author_facet | Fabiola del Carmen Calderón-Zúñiga Guadalupe Ocampo-Gómez Francisco Carlos López-Márquez Rogelio Recio-Vega Luis Benjamín Serrano-Gallardo Pablo Ruiz-Flores |
| author_sort | Fabiola del Carmen Calderón-Zúñiga |
| collection | DOAJ |
| description | Objective. To assess whether in Mexican population the frequencies of ATM polymorphisms IVS24-9delT, IVS38-8T mayor que C, and 5557G mayor que A in breast cancer (BC) cases and healthy controls were different from those found in other countries. Materials and methods. Frequencies of polymorphisms conferring BC risk IVS24-9delT, IVS38-8T mayor que C, and 5557G mayor que A were analyzed by PCR-RFLP in 94 patients with familial and/or early onset BC, and 97 healthy controls randomly selected. Allele frequencies analysis was done using χ2 and Hardy-Weinberg test. Results. Frequencies of heterozygous were: for 5557G mayor que A, 13% cases, 0%controls (p=0.0009); for IVS24-9delT, 21% cases, 8% controls (p=0.0122); for IVS38-8T mayor que C, only one case. 5557G mayor que A and IVS24-9delT were more frequent in cases than in controls. The allelic frequencies found in 5557G mayor que A are similar to those described by González-Hormazábal in Chile. Conclusion. The similarity of results in this polymorphism between Chilean and Mexican populations may be due to both being crossbred with an Amerindian-Spanish component, while differences may be due to fact that Chilean population has a greater European component than Mexican’s. |
| first_indexed | 2024-12-11T01:34:39Z |
| format | Article |
| id | doaj.art-e98b321fd885442b90845f3d0f368b09 |
| institution | Directory Open Access Journal |
| issn | 0036-3634 1606-7916 |
| language | English |
| last_indexed | 2024-12-11T01:34:39Z |
| publishDate | 2014-03-01 |
| publisher | Instituto Nacional de Salud Pública |
| record_format | Article |
| series | Salud Pública de México |
| spelling | doaj.art-e98b321fd885442b90845f3d0f368b092022-12-22T01:25:15ZengInstituto Nacional de Salud PúblicaSalud Pública de México0036-36341606-79162014-03-0156220621210.21149/spm.v56i2.733615795ATM polymorphisms IVS24-9delT, IVS38-8T>C, and 5557G>A in Mexican women with familial and/or early-onset breast cancerFabiola del Carmen Calderón-Zúñiga0Guadalupe Ocampo-Gómez1Francisco Carlos López-Márquez2Rogelio Recio-Vega3Luis Benjamín Serrano-Gallardo4Pablo Ruiz-Flores5Centro de Investigación Biomédica, Universidad Autónoma de Coahuila. Torreón, Coahuila, México.Centro de Investigación Biomédica, Universidad Autónoma de Coahuila. Torreón, Coahuila, México.Centro de Investigación Biomédica, Universidad Autónoma de Coahuila. Torreón, Coahuila, México.Centro de Investigación Biomédica, Universidad Autónoma de Coahuila. Torreón, Coahuila, México.Centro de Investigación Biomédica, Universidad Autónoma de Coahuila. Torreón, Coahuila, México.Centro de Investigación Biomédica, Universidad Autónoma de Coahuila. Torreón, Coahuila, México.Objective. To assess whether in Mexican population the frequencies of ATM polymorphisms IVS24-9delT, IVS38-8T mayor que C, and 5557G mayor que A in breast cancer (BC) cases and healthy controls were different from those found in other countries. Materials and methods. Frequencies of polymorphisms conferring BC risk IVS24-9delT, IVS38-8T mayor que C, and 5557G mayor que A were analyzed by PCR-RFLP in 94 patients with familial and/or early onset BC, and 97 healthy controls randomly selected. Allele frequencies analysis was done using χ2 and Hardy-Weinberg test. Results. Frequencies of heterozygous were: for 5557G mayor que A, 13% cases, 0%controls (p=0.0009); for IVS24-9delT, 21% cases, 8% controls (p=0.0122); for IVS38-8T mayor que C, only one case. 5557G mayor que A and IVS24-9delT were more frequent in cases than in controls. The allelic frequencies found in 5557G mayor que A are similar to those described by González-Hormazábal in Chile. Conclusion. The similarity of results in this polymorphism between Chilean and Mexican populations may be due to both being crossbred with an Amerindian-Spanish component, while differences may be due to fact that Chilean population has a greater European component than Mexican’s.http://www.saludpublica.mx/index.php/spm/article/view/7336ataxia telangiectasia mutated (ATM)breast cancersingle nucleotide polymorphisms (SNP) |
| spellingShingle | Fabiola del Carmen Calderón-Zúñiga Guadalupe Ocampo-Gómez Francisco Carlos López-Márquez Rogelio Recio-Vega Luis Benjamín Serrano-Gallardo Pablo Ruiz-Flores ATM polymorphisms IVS24-9delT, IVS38-8T>C, and 5557G>A in Mexican women with familial and/or early-onset breast cancer Salud Pública de México ataxia telangiectasia mutated (ATM) breast cancer single nucleotide polymorphisms (SNP) |
| title | ATM polymorphisms IVS24-9delT, IVS38-8T>C,
and 5557G>A in Mexican women with familial
and/or early-onset breast cancer |
| title_full | ATM polymorphisms IVS24-9delT, IVS38-8T>C,
and 5557G>A in Mexican women with familial
and/or early-onset breast cancer |
| title_fullStr | ATM polymorphisms IVS24-9delT, IVS38-8T>C,
and 5557G>A in Mexican women with familial
and/or early-onset breast cancer |
| title_full_unstemmed | ATM polymorphisms IVS24-9delT, IVS38-8T>C,
and 5557G>A in Mexican women with familial
and/or early-onset breast cancer |
| title_short | ATM polymorphisms IVS24-9delT, IVS38-8T>C,
and 5557G>A in Mexican women with familial
and/or early-onset breast cancer |
| title_sort | atm polymorphisms ivs24 9delt ivs38 8t c and 5557g a in mexican women with familial and or early onset breast cancer |
| topic | ataxia telangiectasia mutated (ATM) breast cancer single nucleotide polymorphisms (SNP) |
| url | http://www.saludpublica.mx/index.php/spm/article/view/7336 |
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