Vasculitic neuropathy: A retrospective analysis of nerve biopsies and clinical features from a single tertiary care center
Objective: Vasculitic neuropathy can be either restricted to the peripheral nerves or associated with systemic involvement of other organs. The objective of this study was to analyze the nerve biopsies reported as “vasculitic neuropathy” with clinical features. Materials and Methods: All cases diagn...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2019;volume=22;issue=2;spage=180;epage=186;aulast=Hui |
| _version_ | 1818438670607187968 |
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| author | Monalisa Hui A K Meena Liza Rajasekhar Yareeda Sireesha Jabeen Afshan Rukmini Mridula Rupam Borgohain Megha S Uppin |
| author_facet | Monalisa Hui A K Meena Liza Rajasekhar Yareeda Sireesha Jabeen Afshan Rukmini Mridula Rupam Borgohain Megha S Uppin |
| author_sort | Monalisa Hui |
| collection | DOAJ |
| description | Objective: Vasculitic neuropathy can be either restricted to the peripheral nerves or associated with systemic involvement of other organs. The objective of this study was to analyze the nerve biopsies reported as “vasculitic neuropathy” with clinical features. Materials and Methods: All cases diagnosed with vasculitic neuropathy were retrospectively analyzed and categorized as systemic vasculitis and nonsystemic vasculitic neuropathy based on the clinical features. The histological features were further evaluated and classified according to the Peripheral Nerve Society Guidelines. Results: Of the 126 cases, there were 65 nonsystemic vasculitis, 45 secondary systemic vasculitis, and 16 primary systemic vasculitis. Definite vasculitis was more common in the systemic vasculitis group. The epineurial vessels were predominantly involved with chronic axonal changes. Conclusion: The sensitivity of definite vasculitis on nerve biopsy was 54.76%. The sensitivity increases when the diagnostic criteria of definite and probable vasculitis were applied taking into account perivascular inflammation accompanied by vascular changes and axonopathy. |
| first_indexed | 2024-12-14T17:44:16Z |
| format | Article |
| id | doaj.art-e98d84836bc846e39bedfed825b8ff46 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-14T17:44:16Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-e98d84836bc846e39bedfed825b8ff462022-12-21T22:52:47ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492019-01-0122218018610.4103/aian.AIAN_47_18Vasculitic neuropathy: A retrospective analysis of nerve biopsies and clinical features from a single tertiary care centerMonalisa HuiA K MeenaLiza RajasekharYareeda SireeshaJabeen AfshanRukmini MridulaRupam BorgohainMegha S UppinObjective: Vasculitic neuropathy can be either restricted to the peripheral nerves or associated with systemic involvement of other organs. The objective of this study was to analyze the nerve biopsies reported as “vasculitic neuropathy” with clinical features. Materials and Methods: All cases diagnosed with vasculitic neuropathy were retrospectively analyzed and categorized as systemic vasculitis and nonsystemic vasculitic neuropathy based on the clinical features. The histological features were further evaluated and classified according to the Peripheral Nerve Society Guidelines. Results: Of the 126 cases, there were 65 nonsystemic vasculitis, 45 secondary systemic vasculitis, and 16 primary systemic vasculitis. Definite vasculitis was more common in the systemic vasculitis group. The epineurial vessels were predominantly involved with chronic axonal changes. Conclusion: The sensitivity of definite vasculitis on nerve biopsy was 54.76%. The sensitivity increases when the diagnostic criteria of definite and probable vasculitis were applied taking into account perivascular inflammation accompanied by vascular changes and axonopathy.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2019;volume=22;issue=2;spage=180;epage=186;aulast=HuiAxonopathydefinite vasculitisnonsystemic vasculitic neuropathy |
| spellingShingle | Monalisa Hui A K Meena Liza Rajasekhar Yareeda Sireesha Jabeen Afshan Rukmini Mridula Rupam Borgohain Megha S Uppin Vasculitic neuropathy: A retrospective analysis of nerve biopsies and clinical features from a single tertiary care center Annals of Indian Academy of Neurology Axonopathy definite vasculitis nonsystemic vasculitic neuropathy |
| title | Vasculitic neuropathy: A retrospective analysis of nerve biopsies and clinical features from a single tertiary care center |
| title_full | Vasculitic neuropathy: A retrospective analysis of nerve biopsies and clinical features from a single tertiary care center |
| title_fullStr | Vasculitic neuropathy: A retrospective analysis of nerve biopsies and clinical features from a single tertiary care center |
| title_full_unstemmed | Vasculitic neuropathy: A retrospective analysis of nerve biopsies and clinical features from a single tertiary care center |
| title_short | Vasculitic neuropathy: A retrospective analysis of nerve biopsies and clinical features from a single tertiary care center |
| title_sort | vasculitic neuropathy a retrospective analysis of nerve biopsies and clinical features from a single tertiary care center |
| topic | Axonopathy definite vasculitis nonsystemic vasculitic neuropathy |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2019;volume=22;issue=2;spage=180;epage=186;aulast=Hui |
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