Cardiopulmonary exercise test and PaO2 in evaluation of pulmonary hypertension in COPD
Ingunn Skjørten,1,2 Janne Mykland Hilde,3 Morten Nissen Melsom,1 Jonny Hisdal,4 Viggo Hansteen,5 Kjetil Steine,2,3 Sjur Humerfelt6 1Department of Pulmonary Medicine, LHL Glittre Clinic, Hakadal, 2Faculty of Medicine, University of Oslo, Oslo, 3Department of Cardiology, Akershus Universit...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2017-12-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/cardiopulmonary-exercise-test-and-pao2-in-evaluation-of-pulmonary-hype-peer-reviewed-article-COPD |
| _version_ | 1811243485808820224 |
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| author | Skjørten I Hilde JM Melsom MN Hisdal J Hansteen V Steine K Humerfelt S |
| author_facet | Skjørten I Hilde JM Melsom MN Hisdal J Hansteen V Steine K Humerfelt S |
| author_sort | Skjørten I |
| collection | DOAJ |
| description | Ingunn Skjørten,1,2 Janne Mykland Hilde,3 Morten Nissen Melsom,1 Jonny Hisdal,4 Viggo Hansteen,5 Kjetil Steine,2,3 Sjur Humerfelt6 1Department of Pulmonary Medicine, LHL Glittre Clinic, Hakadal, 2Faculty of Medicine, University of Oslo, Oslo, 3Department of Cardiology, Akershus University Hospital, Lørenskog, 4Section of Vascular Investigations, 5Department of Cardiology, Oslo University Hospital-Aker, 6Clinic of Allergology and Respiratory Medicine, Oslo, Norway Background: Exercise tolerance decreases as COPD progresses. Pulmonary hypertension (PH) is common in COPD and may reduce performance further. COPD patients with and without PH could potentially be identified by cardiopulmonary exercise test (CPET). However, results from previous studies are diverging, and a unified conclusion is missing. We hypothesized that CPET combined with arterial blood gases is useful to discriminate between COPD outpatients with and without PH. Methods: In total, 93 COPD patients were prospectively included. Pulmonary function tests, right heart catheterization, and CPET with blood gases were performed. The patients were divided, by mean pulmonary artery pressure, into COPD-noPH (<25 mmHg) and COPD-PH (≥25 mmHg) groups. Linear mixed models (LMMs) were fitted to estimate differences when repeated measurements during the course of exercise were considered and adjusted for gender, age, and airway obstruction. Results: Ventilatory and/or hypoxemic limitation was the dominant cause of exercise termination. In LMM analyses, significant differences between COPD-noPH and COPD-PH were observed for PaO2, SaO2, PaCO2, ventilation, respiratory frequency, and heart rate. PaO2 <61 mmHg (8.1 kPa) during unloaded pedaling, the only load level achieved by all the patients, predicted PH with a sensitivity of 86% and a specificity of 78%. Conclusion: During CPET, low exercise performance and PaO2 strongly indicated PH in COPD patients. Keywords: COPD, pulmonary hypertension, right heart catheterization, cardiopulmonary exercise test, hypoxemia |
| first_indexed | 2024-04-12T14:08:11Z |
| format | Article |
| id | doaj.art-e98e629980a04ff3b8d3706b320872b7 |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-04-12T14:08:11Z |
| publishDate | 2017-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-e98e629980a04ff3b8d3706b320872b72022-12-22T03:30:01ZengDove Medical PressInternational Journal of COPD1178-20052017-12-01Volume 139110036139Cardiopulmonary exercise test and PaO2 in evaluation of pulmonary hypertension in COPDSkjørten IHilde JMMelsom MNHisdal JHansteen VSteine KHumerfelt SIngunn Skjørten,1,2 Janne Mykland Hilde,3 Morten Nissen Melsom,1 Jonny Hisdal,4 Viggo Hansteen,5 Kjetil Steine,2,3 Sjur Humerfelt6 1Department of Pulmonary Medicine, LHL Glittre Clinic, Hakadal, 2Faculty of Medicine, University of Oslo, Oslo, 3Department of Cardiology, Akershus University Hospital, Lørenskog, 4Section of Vascular Investigations, 5Department of Cardiology, Oslo University Hospital-Aker, 6Clinic of Allergology and Respiratory Medicine, Oslo, Norway Background: Exercise tolerance decreases as COPD progresses. Pulmonary hypertension (PH) is common in COPD and may reduce performance further. COPD patients with and without PH could potentially be identified by cardiopulmonary exercise test (CPET). However, results from previous studies are diverging, and a unified conclusion is missing. We hypothesized that CPET combined with arterial blood gases is useful to discriminate between COPD outpatients with and without PH. Methods: In total, 93 COPD patients were prospectively included. Pulmonary function tests, right heart catheterization, and CPET with blood gases were performed. The patients were divided, by mean pulmonary artery pressure, into COPD-noPH (<25 mmHg) and COPD-PH (≥25 mmHg) groups. Linear mixed models (LMMs) were fitted to estimate differences when repeated measurements during the course of exercise were considered and adjusted for gender, age, and airway obstruction. Results: Ventilatory and/or hypoxemic limitation was the dominant cause of exercise termination. In LMM analyses, significant differences between COPD-noPH and COPD-PH were observed for PaO2, SaO2, PaCO2, ventilation, respiratory frequency, and heart rate. PaO2 <61 mmHg (8.1 kPa) during unloaded pedaling, the only load level achieved by all the patients, predicted PH with a sensitivity of 86% and a specificity of 78%. Conclusion: During CPET, low exercise performance and PaO2 strongly indicated PH in COPD patients. Keywords: COPD, pulmonary hypertension, right heart catheterization, cardiopulmonary exercise test, hypoxemiahttps://www.dovepress.com/cardiopulmonary-exercise-test-and-pao2-in-evaluation-of-pulmonary-hype-peer-reviewed-article-COPDCOPDPulmonary hypertensionRight heart catheterizationCardiopulmonary exercise testHypoxemia |
| spellingShingle | Skjørten I Hilde JM Melsom MN Hisdal J Hansteen V Steine K Humerfelt S Cardiopulmonary exercise test and PaO2 in evaluation of pulmonary hypertension in COPD International Journal of COPD COPD Pulmonary hypertension Right heart catheterization Cardiopulmonary exercise test Hypoxemia |
| title | Cardiopulmonary exercise test and PaO2 in evaluation of pulmonary hypertension in COPD |
| title_full | Cardiopulmonary exercise test and PaO2 in evaluation of pulmonary hypertension in COPD |
| title_fullStr | Cardiopulmonary exercise test and PaO2 in evaluation of pulmonary hypertension in COPD |
| title_full_unstemmed | Cardiopulmonary exercise test and PaO2 in evaluation of pulmonary hypertension in COPD |
| title_short | Cardiopulmonary exercise test and PaO2 in evaluation of pulmonary hypertension in COPD |
| title_sort | cardiopulmonary exercise test and pao2 in evaluation of pulmonary hypertension in copd |
| topic | COPD Pulmonary hypertension Right heart catheterization Cardiopulmonary exercise test Hypoxemia |
| url | https://www.dovepress.com/cardiopulmonary-exercise-test-and-pao2-in-evaluation-of-pulmonary-hype-peer-reviewed-article-COPD |
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