When Molecules Meet in Water‐Recent Contributions of Supramolecular Chemistry to the Understanding of Molecular Recognition Processes in Water
Abstract Molecular recognition processes in water differ from those in organic solvents in that they are mediated to a much greater extent by solvent effects. The hydrophobic effect, for example, causes molecules that only weakly interact in organic solvents to stay together in water. Such water‐med...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2022-04-01
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| Series: | ChemistryOpen |
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| Online Access: | https://doi.org/10.1002/open.202200028 |
| _version_ | 1818275116364070912 |
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| author | Prof. Dr. Stefan Kubik |
| author_facet | Prof. Dr. Stefan Kubik |
| author_sort | Prof. Dr. Stefan Kubik |
| collection | DOAJ |
| description | Abstract Molecular recognition processes in water differ from those in organic solvents in that they are mediated to a much greater extent by solvent effects. The hydrophobic effect, for example, causes molecules that only weakly interact in organic solvents to stay together in water. Such water‐mediated interactions can be very efficient as demonstrated by many of the synthetic receptors discussed in this review, some of which have substrate affinities matching or even surpassing those of natural binders. However, in spite of considerable success in designing such receptors, not all factors determining their binding properties in water are fully understood. Existing concepts still provide plausible explanations why the reorganization of water molecules often causes receptor‐substrate interactions in water to be strongly exothermic rather than entropically favored as predicted by the classical view of the hydrophobic effect. |
| first_indexed | 2024-12-12T22:24:38Z |
| format | Article |
| id | doaj.art-e98ef460d8ad4d348ea0a70ef9f14834 |
| institution | Directory Open Access Journal |
| issn | 2191-1363 |
| language | English |
| last_indexed | 2024-12-12T22:24:38Z |
| publishDate | 2022-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | ChemistryOpen |
| spelling | doaj.art-e98ef460d8ad4d348ea0a70ef9f148342022-12-22T00:09:49ZengWiley-VCHChemistryOpen2191-13632022-04-01114n/an/a10.1002/open.202200028When Molecules Meet in Water‐Recent Contributions of Supramolecular Chemistry to the Understanding of Molecular Recognition Processes in WaterProf. Dr. Stefan Kubik0Technische Universität Kaiserslautern Fachbereich Chemie – Organische Chemie Erwin-Schrödinger-Straße 54 67663 Kaiserslautern GermanyAbstract Molecular recognition processes in water differ from those in organic solvents in that they are mediated to a much greater extent by solvent effects. The hydrophobic effect, for example, causes molecules that only weakly interact in organic solvents to stay together in water. Such water‐mediated interactions can be very efficient as demonstrated by many of the synthetic receptors discussed in this review, some of which have substrate affinities matching or even surpassing those of natural binders. However, in spite of considerable success in designing such receptors, not all factors determining their binding properties in water are fully understood. Existing concepts still provide plausible explanations why the reorganization of water molecules often causes receptor‐substrate interactions in water to be strongly exothermic rather than entropically favored as predicted by the classical view of the hydrophobic effect.https://doi.org/10.1002/open.202200028hydrophobic effectmolecular recognitionsupramolecular chemistrysynthetic receptorswater |
| spellingShingle | Prof. Dr. Stefan Kubik When Molecules Meet in Water‐Recent Contributions of Supramolecular Chemistry to the Understanding of Molecular Recognition Processes in Water ChemistryOpen hydrophobic effect molecular recognition supramolecular chemistry synthetic receptors water |
| title | When Molecules Meet in Water‐Recent Contributions of Supramolecular Chemistry to the Understanding of Molecular Recognition Processes in Water |
| title_full | When Molecules Meet in Water‐Recent Contributions of Supramolecular Chemistry to the Understanding of Molecular Recognition Processes in Water |
| title_fullStr | When Molecules Meet in Water‐Recent Contributions of Supramolecular Chemistry to the Understanding of Molecular Recognition Processes in Water |
| title_full_unstemmed | When Molecules Meet in Water‐Recent Contributions of Supramolecular Chemistry to the Understanding of Molecular Recognition Processes in Water |
| title_short | When Molecules Meet in Water‐Recent Contributions of Supramolecular Chemistry to the Understanding of Molecular Recognition Processes in Water |
| title_sort | when molecules meet in water recent contributions of supramolecular chemistry to the understanding of molecular recognition processes in water |
| topic | hydrophobic effect molecular recognition supramolecular chemistry synthetic receptors water |
| url | https://doi.org/10.1002/open.202200028 |
| work_keys_str_mv | AT profdrstefankubik whenmoleculesmeetinwaterrecentcontributionsofsupramolecularchemistrytotheunderstandingofmolecularrecognitionprocessesinwater |