Exploration of the Gut–Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons

Exploration of the Gut–Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons

The gut microbiome is involved in nutrient metabolism and produces metabolites that, via the gut–brain axis, signal to the brain and influence cognition. Human studies have so far had limited success in identifying early metabolic alterations linked to cognitive aging, likely due to limitations in m...

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Bibliographic Details
Main Authors: Jeanne Neuffer, Raúl González-Domínguez, Sophie Lefèvre-Arbogast, Dorrain Y. Low, Bénédicte Driollet, Catherine Helmer, Andrea Du Preez, Chiara de Lucia, Silvie R. Ruigrok, Barbara Altendorfer, Ludwig Aigner, Paul J. Lucassen, Aniko Korosi, Sandrine Thuret, Claudine Manach, Mercè Pallàs, Mireia Urpi-Sardà, Alex Sánchez-Pla, Cristina Andres-Lacueva, Cécilia Samieri
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Nutrients
Subjects:
propionic acid
gut microbiota
metabolomics
cognitive decline
gut–brain axis
Alzheimer’s disease
Online Access:https://www.mdpi.com/2072-6643/14/21/4688

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