Western Diet Decreases the Liver Mitochondrial Oxidative Flux of Succinate: Insight from a Murine NAFLD Model

Western Diet Decreases the Liver Mitochondrial Oxidative Flux of Succinate: Insight from a Murine NAFLD Model

Mitochondria play an essential role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Previously, we found that succinate-activated respiration was the most affected mitochondrial parameter in mice with mild NAFLD. In this study, we focused on the role of succinate dehydrogenase (SDH)...

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Bibliographic Details
Main Authors: Pavla Staňková, Otto Kučera, Eva Peterová, Moustafa Elkalaf, David Rychtrmoc, Jan Melek, Miroslav Podhola, Veronika Zubáňová, Zuzana Červinková
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
nonalcoholic fatty liver disease
mitochondria
oxidative phosphorylation
respirometry
succinate dehydrogenase
succinate
Online Access:https://www.mdpi.com/1422-0067/22/13/6908

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