Neurological consequences of SARS-CoV-2 infections in the pediatric population
COVID-19 in the pediatric population is mostly asymptomatic. However, 1 out of 5 children presents non-specific neurologic symptoms such as headache, weakness, or myalgia. Furthermore, rarer forms of neurological diseases are increasingly being described in association to a SARS-CoV-2 infection. Enc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1123348/full |
| _version_ | 1811164271918186496 |
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| author | Manon Casabianca Caroline Caula Luigi Titomanlio Luigi Titomanlio Luigi Titomanlio Léa Lenglart |
| author_facet | Manon Casabianca Caroline Caula Luigi Titomanlio Luigi Titomanlio Luigi Titomanlio Léa Lenglart |
| author_sort | Manon Casabianca |
| collection | DOAJ |
| description | COVID-19 in the pediatric population is mostly asymptomatic. However, 1 out of 5 children presents non-specific neurologic symptoms such as headache, weakness, or myalgia. Furthermore, rarer forms of neurological diseases are increasingly being described in association to a SARS-CoV-2 infection. Encephalitis, stroke, cranial nerves impairment, Guillain-Barré syndrome or acute transverse myelitis have been reported and account for around 1% of pediatric COVID-19 cases. Some of these pathologies may occur during or after the SARS-CoV-2 infection. The pathophysiological mechanisms range from direct invasion of the central nervous system (CNS) by SARS-CoV-2 itself to postinfectious immune-mediated CNS inflammation. In most cases, patients presenting neurological pathologies related to SARS-CoV-2 infection are at greater risk of life-threatening complications and should be closely monitored. Further studies are needed to acknowledge the potential long-term neurodevelopmental consequences of the infection. |
| first_indexed | 2024-04-10T15:18:51Z |
| format | Article |
| id | doaj.art-e9915fbd8dce4a88a736991fa5a4614d |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-10T15:18:51Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-e9915fbd8dce4a88a736991fa5a4614d2023-02-14T17:17:14ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-02-011110.3389/fped.2023.11233481123348Neurological consequences of SARS-CoV-2 infections in the pediatric populationManon Casabianca0Caroline Caula1Luigi Titomanlio2Luigi Titomanlio3Luigi Titomanlio4Léa Lenglart5Pediatric Emergency Department, APHP - Hopital Robert Debré, Paris Cité University, Paris, FrancePediatric Emergency Department, APHP - Hopital Robert Debré, Paris Cité University, Paris, FrancePediatric Emergency Department, APHP - Hopital Robert Debré, Paris Cité University, Paris, FrancePediatric Migraine and Neurovascular Diseases Unit, APHP - Hopital Robert Debré, Paris Cité University, Paris, FranceDHU Protect, INSERM U1141, Paris Cité University, Paris, FrancePediatric Emergency Department, APHP - Hopital Robert Debré, Paris Cité University, Paris, FranceCOVID-19 in the pediatric population is mostly asymptomatic. However, 1 out of 5 children presents non-specific neurologic symptoms such as headache, weakness, or myalgia. Furthermore, rarer forms of neurological diseases are increasingly being described in association to a SARS-CoV-2 infection. Encephalitis, stroke, cranial nerves impairment, Guillain-Barré syndrome or acute transverse myelitis have been reported and account for around 1% of pediatric COVID-19 cases. Some of these pathologies may occur during or after the SARS-CoV-2 infection. The pathophysiological mechanisms range from direct invasion of the central nervous system (CNS) by SARS-CoV-2 itself to postinfectious immune-mediated CNS inflammation. In most cases, patients presenting neurological pathologies related to SARS-CoV-2 infection are at greater risk of life-threatening complications and should be closely monitored. Further studies are needed to acknowledge the potential long-term neurodevelopmental consequences of the infection.https://www.frontiersin.org/articles/10.3389/fped.2023.1123348/fullSARS-CoV-2encephalitischildrenCOVID-19anosmia |
| spellingShingle | Manon Casabianca Caroline Caula Luigi Titomanlio Luigi Titomanlio Luigi Titomanlio Léa Lenglart Neurological consequences of SARS-CoV-2 infections in the pediatric population Frontiers in Pediatrics SARS-CoV-2 encephalitis children COVID-19 anosmia |
| title | Neurological consequences of SARS-CoV-2 infections in the pediatric population |
| title_full | Neurological consequences of SARS-CoV-2 infections in the pediatric population |
| title_fullStr | Neurological consequences of SARS-CoV-2 infections in the pediatric population |
| title_full_unstemmed | Neurological consequences of SARS-CoV-2 infections in the pediatric population |
| title_short | Neurological consequences of SARS-CoV-2 infections in the pediatric population |
| title_sort | neurological consequences of sars cov 2 infections in the pediatric population |
| topic | SARS-CoV-2 encephalitis children COVID-19 anosmia |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1123348/full |
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