Long-term surgical outcomes in patients with hepatocellular carcinoma undergoing laparoscopic vs. open liver resection: A retrospective and propensity score-matched study
Background/objectives: There is limited availability of well-designed comparative studies using propensity score matching with a sufficient sample size to compare laparoscopic liver resection (LLR) vs. open liver resection (OLR) for hepatocellular carcinoma (HCC). We aimed to compare the feasibility...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
|
| Series: | Asian Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958420301652 |
| _version_ | 1818666928114237440 |
|---|---|
| author | Doo-Ho Lee Doojin Kim Yeon Ho Park Jinmyeong Yoon Joo Seop Kim |
| author_facet | Doo-Ho Lee Doojin Kim Yeon Ho Park Jinmyeong Yoon Joo Seop Kim |
| author_sort | Doo-Ho Lee |
| collection | DOAJ |
| description | Background/objectives: There is limited availability of well-designed comparative studies using propensity score matching with a sufficient sample size to compare laparoscopic liver resection (LLR) vs. open liver resection (OLR) for hepatocellular carcinoma (HCC). We aimed to compare the feasibility and safety of LLR and OLR in patients with HCC. Methods: We enrolled 168 patients who underwent elective LLR (n = 58) or OLR (n = 110) for HCC in two tertiary medical centers between November 2009 and December 2018. Patients who underwent LLR were propensity score-matched to patients who underwent OLR in a 1:1 ratio. Perioperative and postoperative outcomes and disease-free and overall survival rates were prospectively evaluated. Results: Among the 116 patients analyzed, 58 each belonged to the LLR and OLR groups. We performed 85 segmentectomies or sectionectomies, 19 left-lateral-sectionectomies, 9 left-hemihepatectomies, and 3 right-hemihepatectomies. There was no significant difference in age, sex, Child-Pugh class, original liver disease, preoperative alpha-fetoprotein, tumor size, tumor location, overall morbidity, and operative time. There was a significant difference in the length of postoperative hospital stay between the two groups (LLR vs OLR; 8 vs 10 days, p = 0.003). The 1-, 3-, and 5-year overall survival rates in the LLR and OLR groups were 96.6%, 92.8%, and 73.3% and 93.1%, 88.8%, and 76.1%, respectively (p = 0.642). The 1-, 3-, and 5-year disease-free survival rates in the LLR and OLR groups were 84.4%, 64.0%, and 60.2% and 93.1%, 67.4%, and 63.9%, respectively (p = 0.391). Conclusion: LLR for HCC can be performed safely with acceptable short-term and long-term outcomes compared with OLR. |
| first_indexed | 2024-12-17T06:12:19Z |
| format | Article |
| id | doaj.art-e991ae623c2b47969fe80afe6e74fe79 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-17T06:12:19Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-e991ae623c2b47969fe80afe6e74fe792022-12-21T22:00:36ZengElsevierAsian Journal of Surgery1015-95842021-01-01441206212Long-term surgical outcomes in patients with hepatocellular carcinoma undergoing laparoscopic vs. open liver resection: A retrospective and propensity score-matched studyDoo-Ho Lee0Doojin Kim1Yeon Ho Park2Jinmyeong Yoon3Joo Seop Kim4Department of Surgery, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, South KoreaDepartment of Surgery, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, South KoreaDepartment of Surgery, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, South Korea; Corresponding author. Department of Surgery, Gil Medical Center, Gachon University, School of Medicine, Namdong-daero, Namdong-gu, Incheon, 21565, South Korea.Department of Surgery, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, South KoreaDepartment of Surgery, Kangdong Sungsim Hospital, Hallym University School of Medicine, Seoul, South KoreaBackground/objectives: There is limited availability of well-designed comparative studies using propensity score matching with a sufficient sample size to compare laparoscopic liver resection (LLR) vs. open liver resection (OLR) for hepatocellular carcinoma (HCC). We aimed to compare the feasibility and safety of LLR and OLR in patients with HCC. Methods: We enrolled 168 patients who underwent elective LLR (n = 58) or OLR (n = 110) for HCC in two tertiary medical centers between November 2009 and December 2018. Patients who underwent LLR were propensity score-matched to patients who underwent OLR in a 1:1 ratio. Perioperative and postoperative outcomes and disease-free and overall survival rates were prospectively evaluated. Results: Among the 116 patients analyzed, 58 each belonged to the LLR and OLR groups. We performed 85 segmentectomies or sectionectomies, 19 left-lateral-sectionectomies, 9 left-hemihepatectomies, and 3 right-hemihepatectomies. There was no significant difference in age, sex, Child-Pugh class, original liver disease, preoperative alpha-fetoprotein, tumor size, tumor location, overall morbidity, and operative time. There was a significant difference in the length of postoperative hospital stay between the two groups (LLR vs OLR; 8 vs 10 days, p = 0.003). The 1-, 3-, and 5-year overall survival rates in the LLR and OLR groups were 96.6%, 92.8%, and 73.3% and 93.1%, 88.8%, and 76.1%, respectively (p = 0.642). The 1-, 3-, and 5-year disease-free survival rates in the LLR and OLR groups were 84.4%, 64.0%, and 60.2% and 93.1%, 67.4%, and 63.9%, respectively (p = 0.391). Conclusion: LLR for HCC can be performed safely with acceptable short-term and long-term outcomes compared with OLR.http://www.sciencedirect.com/science/article/pii/S1015958420301652Hepatocellular carcinomaLaparoscopicLiver resection |
| spellingShingle | Doo-Ho Lee Doojin Kim Yeon Ho Park Jinmyeong Yoon Joo Seop Kim Long-term surgical outcomes in patients with hepatocellular carcinoma undergoing laparoscopic vs. open liver resection: A retrospective and propensity score-matched study Asian Journal of Surgery Hepatocellular carcinoma Laparoscopic Liver resection |
| title | Long-term surgical outcomes in patients with hepatocellular carcinoma undergoing laparoscopic vs. open liver resection: A retrospective and propensity score-matched study |
| title_full | Long-term surgical outcomes in patients with hepatocellular carcinoma undergoing laparoscopic vs. open liver resection: A retrospective and propensity score-matched study |
| title_fullStr | Long-term surgical outcomes in patients with hepatocellular carcinoma undergoing laparoscopic vs. open liver resection: A retrospective and propensity score-matched study |
| title_full_unstemmed | Long-term surgical outcomes in patients with hepatocellular carcinoma undergoing laparoscopic vs. open liver resection: A retrospective and propensity score-matched study |
| title_short | Long-term surgical outcomes in patients with hepatocellular carcinoma undergoing laparoscopic vs. open liver resection: A retrospective and propensity score-matched study |
| title_sort | long term surgical outcomes in patients with hepatocellular carcinoma undergoing laparoscopic vs open liver resection a retrospective and propensity score matched study |
| topic | Hepatocellular carcinoma Laparoscopic Liver resection |
| url | http://www.sciencedirect.com/science/article/pii/S1015958420301652 |
| work_keys_str_mv | AT dooholee longtermsurgicaloutcomesinpatientswithhepatocellularcarcinomaundergoinglaparoscopicvsopenliverresectionaretrospectiveandpropensityscorematchedstudy AT doojinkim longtermsurgicaloutcomesinpatientswithhepatocellularcarcinomaundergoinglaparoscopicvsopenliverresectionaretrospectiveandpropensityscorematchedstudy AT yeonhopark longtermsurgicaloutcomesinpatientswithhepatocellularcarcinomaundergoinglaparoscopicvsopenliverresectionaretrospectiveandpropensityscorematchedstudy AT jinmyeongyoon longtermsurgicaloutcomesinpatientswithhepatocellularcarcinomaundergoinglaparoscopicvsopenliverresectionaretrospectiveandpropensityscorematchedstudy AT jooseopkim longtermsurgicaloutcomesinpatientswithhepatocellularcarcinomaundergoinglaparoscopicvsopenliverresectionaretrospectiveandpropensityscorematchedstudy |