HLAProfiler utilizes k-mer profiles to improve HLA calling accuracy for rare and common alleles in RNA-seq data

HLAProfiler utilizes k-mer profiles to improve HLA calling accuracy for rare and common alleles in RNA-seq data

Abstract Background The human leukocyte antigen (HLA) system is a genomic region involved in regulating the human immune system by encoding cell membrane major histocompatibility complex (MHC) proteins that are responsible for self-recognition. Understanding the variation in this region provides imp...

ver descrição completa

Detalhes bibliográficos
Principais autores: Martin L. Buchkovich, Chad C. Brown, Kimberly Robasky, Shengjie Chai, Sharon Westfall, Benjamin G. Vincent, Eric T. Weimer, Jason G. Powers
Formato: Artigo
Idioma:English
Publicado em: BMC 2017-09-01
coleção:Genome Medicine
Assuntos:
HLA
HSCT
Transplantation
Immunology
RNA-sequencing
Acesso em linha:http://link.springer.com/article/10.1186/s13073-017-0473-6

Registros relacionados

Registros relacionados