HLAProfiler utilizes k-mer profiles to improve HLA calling accuracy for rare and common alleles in RNA-seq data

HLAProfiler utilizes k-mer profiles to improve HLA calling accuracy for rare and common alleles in RNA-seq data

Abstract Background The human leukocyte antigen (HLA) system is a genomic region involved in regulating the human immune system by encoding cell membrane major histocompatibility complex (MHC) proteins that are responsible for self-recognition. Understanding the variation in this region provides imp...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Martin L. Buchkovich, Chad C. Brown, Kimberly Robasky, Shengjie Chai, Sharon Westfall, Benjamin G. Vincent, Eric T. Weimer, Jason G. Powers
Format: Artikel
Sprache:English
Veröffentlicht: BMC 2017-09-01
Schriftenreihe:Genome Medicine
Schlagworte:
HLA
HSCT
Transplantation
Immunology
RNA-sequencing
Online Zugang:http://link.springer.com/article/10.1186/s13073-017-0473-6

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