A Fiber-Tip Label-Free Biological Sensing Platform: A Practical Approach toward In-Vivo Sensing
The platform presented here was devised to address the unmet need for real time label-free in vivo sensing by bringing together a refractive index transduction mechanism based on Whispering Gallery Modes (WGM) in dye doped microspheres and Microstructured Optical Fibers. In addition to providing rem...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-01-01
|
| Series: | Sensors |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8220/15/1/1168 |
| _version_ | 1798040300369739776 |
|---|---|
| author | Alexandre François Tess Reynolds Tanya M. Monro |
| author_facet | Alexandre François Tess Reynolds Tanya M. Monro |
| author_sort | Alexandre François |
| collection | DOAJ |
| description | The platform presented here was devised to address the unmet need for real time label-free in vivo sensing by bringing together a refractive index transduction mechanism based on Whispering Gallery Modes (WGM) in dye doped microspheres and Microstructured Optical Fibers. In addition to providing remote excitation and collection of the WGM signal, the fiber provides significant practical advantages such as an easy manipulation of the microresonator and the use of this sensor in a dip sensing architecture, alleviating the need for a complex microfluidic interface. Here, we present the first demonstration of the use of this approach for biological sensing and evaluate its limitation in a sensing configuration deprived of liquid flow which is most likely to occur in an in vivo setting. We also demonstrate the ability of this sensing platform to be operated above its lasing threshold, enabling enhanced device performance. |
| first_indexed | 2024-04-11T22:05:43Z |
| format | Article |
| id | doaj.art-e991e7cfe0b44d3e8896528c9f8669b7 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T22:05:43Z |
| publishDate | 2015-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-e991e7cfe0b44d3e8896528c9f8669b72022-12-22T04:00:44ZengMDPI AGSensors1424-82202015-01-011511168118110.3390/s150101168s150101168A Fiber-Tip Label-Free Biological Sensing Platform: A Practical Approach toward In-Vivo SensingAlexandre François0Tess Reynolds1Tanya M. Monro2The Institute for Photonics and Advanced Sensing (IPAS) and ARC Centre of Excellence for Nanoscale Biophotonics (CNBP), the University of Adelaide, Adelaide SA 5005, AustraliaThe Institute for Photonics and Advanced Sensing (IPAS) and ARC Centre of Excellence for Nanoscale Biophotonics (CNBP), the University of Adelaide, Adelaide SA 5005, AustraliaThe Institute for Photonics and Advanced Sensing (IPAS) and ARC Centre of Excellence for Nanoscale Biophotonics (CNBP), the University of Adelaide, Adelaide SA 5005, AustraliaThe platform presented here was devised to address the unmet need for real time label-free in vivo sensing by bringing together a refractive index transduction mechanism based on Whispering Gallery Modes (WGM) in dye doped microspheres and Microstructured Optical Fibers. In addition to providing remote excitation and collection of the WGM signal, the fiber provides significant practical advantages such as an easy manipulation of the microresonator and the use of this sensor in a dip sensing architecture, alleviating the need for a complex microfluidic interface. Here, we present the first demonstration of the use of this approach for biological sensing and evaluate its limitation in a sensing configuration deprived of liquid flow which is most likely to occur in an in vivo setting. We also demonstrate the ability of this sensing platform to be operated above its lasing threshold, enabling enhanced device performance.http://www.mdpi.com/1424-8220/15/1/1168fiber optics sensorsbiological sensorsmicrocavitieslaser resonators |
| spellingShingle | Alexandre François Tess Reynolds Tanya M. Monro A Fiber-Tip Label-Free Biological Sensing Platform: A Practical Approach toward In-Vivo Sensing Sensors fiber optics sensors biological sensors microcavities laser resonators |
| title | A Fiber-Tip Label-Free Biological Sensing Platform: A Practical Approach toward In-Vivo Sensing |
| title_full | A Fiber-Tip Label-Free Biological Sensing Platform: A Practical Approach toward In-Vivo Sensing |
| title_fullStr | A Fiber-Tip Label-Free Biological Sensing Platform: A Practical Approach toward In-Vivo Sensing |
| title_full_unstemmed | A Fiber-Tip Label-Free Biological Sensing Platform: A Practical Approach toward In-Vivo Sensing |
| title_short | A Fiber-Tip Label-Free Biological Sensing Platform: A Practical Approach toward In-Vivo Sensing |
| title_sort | fiber tip label free biological sensing platform a practical approach toward in vivo sensing |
| topic | fiber optics sensors biological sensors microcavities laser resonators |
| url | http://www.mdpi.com/1424-8220/15/1/1168 |
| work_keys_str_mv | AT alexandrefrancois afibertiplabelfreebiologicalsensingplatformapracticalapproachtowardinvivosensing AT tessreynolds afibertiplabelfreebiologicalsensingplatformapracticalapproachtowardinvivosensing AT tanyammonro afibertiplabelfreebiologicalsensingplatformapracticalapproachtowardinvivosensing AT alexandrefrancois fibertiplabelfreebiologicalsensingplatformapracticalapproachtowardinvivosensing AT tessreynolds fibertiplabelfreebiologicalsensingplatformapracticalapproachtowardinvivosensing AT tanyammonro fibertiplabelfreebiologicalsensingplatformapracticalapproachtowardinvivosensing |